ENSG00000197050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337995 ENSG00000197050 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF420 protein_coding protein_coding 3.979252 1.827089 6.162834 0.167106 0.1832638 1.748511 2.4685758 0.81058100 3.5002168 0.03442673 0.16958456 2.0968425 0.61281667 0.4523333 0.57003333 0.11770000 0.37518490 0.01164564 FALSE TRUE
ENST00000585862 ENSG00000197050 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF420 protein_coding protein_coding 3.979252 1.827089 6.162834 0.167106 0.1832638 1.748511 0.2118607 0.24969208 0.3694831 0.18432954 0.18921576 0.5472338 0.07020833 0.1348333 0.05923333 -0.07560000 0.90431199 0.01164564 FALSE TRUE
ENST00000586540 ENSG00000197050 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF420 protein_coding processed_transcript 3.979252 1.827089 6.162834 0.167106 0.1832638 1.748511 0.4426947 0.21087285 0.9801690 0.14129045 0.26187585 2.1644586 0.10213750 0.1034333 0.15793333 0.05450000 0.70536626 0.01164564 FALSE FALSE
ENST00000589245 ENSG00000197050 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF420 protein_coding protein_coding 3.979252 1.827089 6.162834 0.167106 0.1832638 1.748511 0.3519266 0.01467494 0.4291240 0.01467494 0.09205618 4.1535100 0.05912917 0.0069000 0.06896667 0.06206667 0.03230697 0.01164564 FALSE TRUE
MSTRG.17053.7 ENSG00000197050 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF420 protein_coding   3.979252 1.827089 6.162834 0.167106 0.1832638 1.748511 0.2054464 0.39937794 0.1319289 0.12001970 0.06717842 -1.5282650 0.08677500 0.2154667 0.02090000 -0.19456667 0.01164564 0.01164564   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197050 E001 0.0000000       19 37007857 37007858 2 +      
ENSG00000197050 E002 0.0000000       19 37007859 37008082 224 +      
ENSG00000197050 E003 1.3587781 0.0096765512 9.908642e-01 9.984411e-01 19 37078418 37078432 15 + 0.345 0.347 0.011
ENSG00000197050 E004 1.3587781 0.0096765512 9.908642e-01 9.984411e-01 19 37078433 37078434 2 + 0.345 0.347 0.011
ENSG00000197050 E005 2.0628717 0.0071262428 1.330882e-01 2.384282e-01 19 37078435 37078445 11 + 0.512 0.207 -1.882
ENSG00000197050 E006 14.9670127 0.0228131740 1.600137e-01 2.751352e-01 19 37078446 37078570 125 + 1.191 1.006 -0.667
ENSG00000197050 E007 12.2075375 0.0189594912 2.421597e-01 3.767465e-01 19 37080345 37080388 44 + 1.106 0.950 -0.571
ENSG00000197050 E008 19.1142418 0.0316071708 6.600794e-01 7.687866e-01 19 37089039 37089127 89 + 1.241 1.283 0.147
ENSG00000197050 E009 21.1984870 0.0013141278 8.845393e-01 9.301806e-01 19 37090995 37091121 127 + 1.298 1.286 -0.043
ENSG00000197050 E010 1.2963344 0.0150937691 3.287061e-01 4.721862e-01 19 37096031 37096115 85 + 0.271 0.452 1.082
ENSG00000197050 E011 0.7320925 0.0569470734 2.640849e-01 4.020290e-01 19 37111600 37111711 112 + 0.271 0.001 -8.749
ENSG00000197050 E012 76.6373380 0.0003662499 7.145148e-06 4.909426e-05 19 37127128 37128166 1039 + 1.877 1.671 -0.697
ENSG00000197050 E013 32.3775074 0.0047042767 1.966629e-01 3.220768e-01 19 37128167 37128402 236 + 1.486 1.385 -0.348
ENSG00000197050 E014 27.1531725 0.0106414957 1.119480e-01 2.084201e-01 19 37128403 37128612 210 + 1.423 1.274 -0.519
ENSG00000197050 E015 32.6154202 0.0049364811 4.478746e-02 9.981706e-02 19 37128613 37128906 294 + 1.505 1.350 -0.538
ENSG00000197050 E016 62.8214749 0.0004342965 4.364032e-03 1.415963e-02 19 37128907 37130036 1130 + 1.711 1.838 0.429
ENSG00000197050 E017 19.3400443 0.0010363046 1.706037e-05 1.074730e-04 19 37130037 37130143 107 + 1.146 1.482 1.175
ENSG00000197050 E018 22.1381207 0.0051661646 8.442677e-10 1.267787e-08 19 37130144 37130368 225 + 1.140 1.614 1.646