ENSG00000197045

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358056 ENSG00000197045 HEK293_OSMI2_2hA HEK293_TMG_2hB GMFB protein_coding protein_coding 21.6141 4.660251 40.84451 1.706638 2.942461 3.128923 17.87359 4.50452564 33.902798 1.73375945 2.099121 2.909183 0.8591875 0.9551667 0.8313667 -0.1238 0.0205119999 0.0003183422 FALSE TRUE
MSTRG.9568.4 ENSG00000197045 HEK293_OSMI2_2hA HEK293_TMG_2hB GMFB protein_coding   21.6141 4.660251 40.84451 1.706638 2.942461 3.128923 2.34853 0.04264666 4.293919 0.02132612 1.156585 6.353165 0.0671375 0.0100000 0.1035000 0.0935 0.0003183422 0.0003183422 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197045 E001 0.5212538 0.0209999634 2.314826e-02 5.805591e-02 14 54474484 54474484 1 - 0.041 0.499 4.456
ENSG00000197045 E002 3.0727056 0.0551119145 8.170334e-07 6.914654e-06 14 54474485 54474490 6 - 0.201 1.171 4.552
ENSG00000197045 E003 1511.0117963 0.0118884356 2.031397e-07 1.944137e-06 14 54474491 54477599 3109 - 2.917 3.214 0.988
ENSG00000197045 E004 273.7033462 0.0001853336 1.212062e-07 1.211915e-06 14 54477600 54477857 258 - 2.220 2.205 -0.049
ENSG00000197045 E005 119.4281176 0.0284864403 9.603252e-02 1.844148e-01 14 54477858 54477921 64 - 1.865 1.835 -0.100
ENSG00000197045 E006 122.4384086 0.0002709542 6.666243e-04 2.776397e-03 14 54477922 54477982 61 - 1.874 1.865 -0.031
ENSG00000197045 E007 123.8652711 0.0002526170 2.106633e-05 1.299646e-04 14 54477983 54478105 123 - 1.883 1.824 -0.197
ENSG00000197045 E008 110.5854155 0.0174800053 2.212044e-02 5.592381e-02 14 54478106 54478159 54 - 1.833 1.777 -0.187
ENSG00000197045 E009 11.0259393 0.0016132880 5.998210e-02 1.265768e-01 14 54478160 54479785 1626 - 0.896 0.725 -0.673
ENSG00000197045 E010 149.1075282 0.0002299992 1.436294e-08 1.719333e-07 14 54479786 54479859 74 - 1.967 1.852 -0.388
ENSG00000197045 E011 5.3731388 0.0069067050 8.833756e-01 9.293898e-01 14 54479860 54480873 1014 - 0.617 0.725 0.454
ENSG00000197045 E012 129.4854254 0.0009364470 6.041778e-06 4.222669e-05 14 54480874 54480941 68 - 1.904 1.824 -0.271
ENSG00000197045 E013 64.9633526 0.0010523555 6.846036e-02 1.408194e-01 14 54480942 54480955 14 - 1.599 1.634 0.119
ENSG00000197045 E014 62.9842566 0.0005817043 4.863707e-02 1.067490e-01 14 54480956 54480956 1 - 1.587 1.611 0.084
ENSG00000197045 E015 10.7828485 0.0016359783 1.716658e-01 2.903879e-01 14 54480957 54480959 3 - 0.880 0.806 -0.288
ENSG00000197045 E016 0.7792333 0.0888791176 5.667768e-01 6.936613e-01 14 54480960 54480962 3 - 0.144 0.318 1.456
ENSG00000197045 E017 3.8825508 0.0041108963 2.857963e-01 4.261604e-01 14 54481326 54481394 69 - 0.486 0.805 1.384
ENSG00000197045 E018 1.8017849 0.0092026892 7.584716e-01 8.430642e-01 14 54481395 54481407 13 - 0.318 0.318 -0.003
ENSG00000197045 E019 2.9841572 0.0048780489 3.080545e-01 4.502947e-01 14 54481408 54481408 1 - 0.457 0.318 -0.792
ENSG00000197045 E020 113.5578201 0.0035124855 3.099910e-02 7.391398e-02 14 54481409 54481458 50 - 1.838 1.863 0.086
ENSG00000197045 E021 1.4749078 0.0087723434 2.830271e-01 4.231001e-01 14 54482122 54482152 31 - 0.297 0.000 -21.730
ENSG00000197045 E022 125.9975514 0.0005184586 3.861324e-05 2.233842e-04 14 54482153 54482202 50 - 1.890 1.838 -0.175
ENSG00000197045 E023 4.7593541 0.0210241789 1.217793e-02 3.395637e-02 14 54483128 54483670 543 - 0.618 0.000 -23.410
ENSG00000197045 E024 131.9902374 0.0054589883 1.757936e-03 6.465333e-03 14 54483671 54483767 97 - 1.909 1.874 -0.120
ENSG00000197045 E025 0.1451727 0.0460476762 7.349320e-01   14 54483768 54483768 1 - 0.041 0.000 -18.408
ENSG00000197045 E026 0.6017953 0.1985513236 1.000000e+00 1.000000e+00 14 54483933 54484060 128 - 0.144 0.000 -20.413
ENSG00000197045 E027 0.0000000       14 54488607 54488681 75 -      
ENSG00000197045 E028 1.3402305 0.0504177665 3.522646e-01 4.965326e-01 14 54488682 54488924 243 - 0.275 0.000 -21.579
ENSG00000197045 E029 83.9885388 0.0116052324 1.162025e-02 3.262814e-02 14 54488925 54489238 314 - 1.717 1.670 -0.162