ENSG00000197024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426851 ENSG00000197024 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF398 protein_coding protein_coding 10.97121 11.06981 11.91494 0.386519 0.09025654 0.1060485 1.347877 1.265317 1.3651849 0.11646310 0.2251903 0.1087695 0.1349625 0.1141667 0.11480000 0.0006333333 1.000000000 0.001271694 FALSE TRUE
ENST00000475153 ENSG00000197024 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF398 protein_coding protein_coding 10.97121 11.06981 11.91494 0.386519 0.09025654 0.1060485 5.904831 3.651033 8.5592642 0.69439226 0.3810375 1.2269205 0.5313667 0.3347667 0.71850000 0.3837333333 0.001271694 0.001271694 FALSE TRUE
MSTRG.30896.3 ENSG00000197024 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF398 protein_coding   10.97121 11.06981 11.91494 0.386519 0.09025654 0.1060485 2.080107 4.335780 0.1574943 0.47968816 0.1574943 -4.6974315 0.1844625 0.3896667 0.01333333 -0.3763333333 0.002168107 0.001271694 FALSE TRUE
MSTRG.30896.4 ENSG00000197024 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF398 protein_coding   10.97121 11.06981 11.91494 0.386519 0.09025654 0.1060485 1.053780 1.069584 1.5835488 0.04905542 0.4015441 0.5617672 0.0955125 0.0966000 0.13256667 0.0359666667 0.739822480 0.001271694 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197024 E001 3.3328751 0.0305374838 6.292958e-01 7.446855e-01 7 149126416 149126463 48 + 0.573 0.711 0.594
ENSG00000197024 E002 8.7589337 0.0023565086 4.932798e-01 6.303014e-01 7 149126464 149126655 192 + 0.920 1.058 0.513
ENSG00000197024 E003 3.8581128 0.0515942053 1.103417e-02 3.124463e-02 7 149127097 149127125 29 + 0.346 0.846 2.304
ENSG00000197024 E004 4.6459847 0.0241536691 4.699089e-01 6.091320e-01 7 149128823 149128944 122 + 0.769 0.716 -0.216
ENSG00000197024 E005 0.5181333 0.0207120964 5.536537e-01 6.827581e-01 7 149147012 149147107 96 + 0.207 0.130 -0.806
ENSG00000197024 E006 4.3009993 0.0044513338 7.342939e-02 1.490116e-01 7 149147108 149147242 135 + 0.812 0.616 -0.807
ENSG00000197024 E007 32.1722424 0.0088571137 2.408527e-07 2.273144e-06 7 149147453 149147766 314 + 1.655 1.321 -1.146
ENSG00000197024 E008 0.1482932 0.0411569638 4.986322e-01   7 149148127 149148283 157 + 0.000 0.129 9.569
ENSG00000197024 E009 0.0000000       7 149148403 149148516 114 +      
ENSG00000197024 E010 0.3299976 0.0274424043 2.080214e-01   7 149151207 149151282 76 + 0.000 0.229 10.727
ENSG00000197024 E011 124.3302813 0.0020741326 3.249912e-07 2.984855e-06 7 149153945 149154317 373 + 2.155 2.034 -0.404
ENSG00000197024 E012 34.6100195 0.0006992286 1.483876e-02 4.012616e-02 7 149154318 149154340 23 + 1.592 1.518 -0.251
ENSG00000197024 E013 73.0756223 0.0024590185 4.128796e-04 1.823792e-03 7 149166158 149166284 127 + 1.919 1.826 -0.313
ENSG00000197024 E014 76.6174116 0.0031907981 4.879767e-02 1.070221e-01 7 149166817 149166930 114 + 1.904 1.881 -0.078
ENSG00000197024 E015 78.4294627 0.0003567610 1.209724e-01 2.213303e-01 7 149176468 149176581 114 + 1.896 1.905 0.030
ENSG00000197024 E016 1448.1372813 0.0034618809 9.554322e-08 9.737143e-07 7 149178648 149183042 4395 + 3.100 3.212 0.373