ENSG00000197020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305570 ENSG00000197020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF100 protein_coding protein_coding 4.307437 0.6654726 7.474016 0.01041034 0.2431568 3.469843 0.2401883 0.0000000 0.3897110 0.00000000 0.2181927 5.320885 0.04628333 0.0000000 0.05203333 0.05203333 6.965465e-01 6.20827e-06 FALSE TRUE
ENST00000358296 ENSG00000197020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF100 protein_coding protein_coding 4.307437 0.6654726 7.474016 0.01041034 0.2431568 3.469843 1.1993337 0.4455436 1.7143085 0.01461161 0.1491165 1.920357 0.42786667 0.6696333 0.23090000 -0.43873333 6.208270e-06 6.20827e-06 FALSE TRUE
MSTRG.16844.3 ENSG00000197020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF100 protein_coding   4.307437 0.6654726 7.474016 0.01041034 0.2431568 3.469843 2.4093988 0.1895935 4.1434969 0.04357514 0.1088593 4.379190 0.41624167 0.2850667 0.55616667 0.27110000 2.291208e-02 6.20827e-06 FALSE TRUE
MSTRG.16844.4 ENSG00000197020 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF100 protein_coding   4.307437 0.6654726 7.474016 0.01041034 0.2431568 3.469843 0.2763796 0.0000000 0.9804878 0.00000000 0.6078976 6.630067 0.06881250 0.0000000 0.12690000 0.12690000 5.873473e-01 6.20827e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197020 E001 78.7854347 0.0111234139 7.995821e-09 1.003900e-07 19 21722771 21726192 3422 - 1.698 2.028 1.111
ENSG00000197020 E002 22.5766419 0.0008804688 4.536719e-02 1.008682e-01 19 21726193 21726343 151 - 1.270 1.066 -0.728
ENSG00000197020 E003 119.8212229 0.0192945763 3.611542e-03 1.204273e-02 19 21726344 21727613 1270 - 1.973 1.794 -0.603
ENSG00000197020 E004 40.3332014 0.0005704826 5.512413e-03 1.731915e-02 19 21727614 21727930 317 - 1.511 1.297 -0.742
ENSG00000197020 E005 15.5765391 0.0013060977 5.062508e-01 6.419041e-01 19 21727931 21727989 59 - 1.102 1.034 -0.248
ENSG00000197020 E006 0.7437457 0.0157778464 7.030884e-01 8.018276e-01 19 21743078 21743223 146 - 0.181 0.259 0.657
ENSG00000197020 E007 16.9062341 0.0090761585 3.344801e-01 4.782215e-01 19 21744017 21744112 96 - 1.144 1.034 -0.398
ENSG00000197020 E008 6.3931070 0.0339314327 7.485333e-01 8.357539e-01 19 21744113 21744115 3 - 0.762 0.708 -0.221
ENSG00000197020 E009 21.6334410 0.0077899196 8.239641e-01 8.890799e-01 19 21744941 21745067 127 - 1.232 1.218 -0.048
ENSG00000197020 E010 0.0000000       19 21746816 21746889 74 -      
ENSG00000197020 E011 0.0000000       19 21750521 21750783 263 -      
ENSG00000197020 E012 1.5197568 0.0096394319 1.968465e-01 3.222938e-01 19 21753193 21753573 381 - 0.280 0.538 1.435
ENSG00000197020 E013 28.4137803 0.0069637586 7.263619e-01 8.194165e-01 19 21765694 21765786 93 - 1.334 1.378 0.151
ENSG00000197020 E014 26.7031566 0.0093485760 4.942002e-01 6.311691e-01 19 21767427 21767618 192 - 1.302 1.378 0.264