ENSG00000197016

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330619 ENSG00000197016 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF470 protein_coding protein_coding 1.317769 0.9139009 1.340156 0.118669 0.08054018 0.5473162 0.70830326 0.18234843 1.02159515 0.09119325 0.045887361 2.4230829 0.51888750 0.22933333 0.7639667 0.53463333 4.061955e-02 8.822455e-06 FALSE TRUE
ENST00000391709 ENSG00000197016 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF470 protein_coding protein_coding 1.317769 0.9139009 1.340156 0.118669 0.08054018 0.5473162 0.04355971 0.12113529 0.00000000 0.12113529 0.000000000 -3.7129841 0.04362917 0.10543333 0.0000000 -0.10543333 6.789596e-01 8.822455e-06 FALSE TRUE
ENST00000601579 ENSG00000197016 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF470 protein_coding processed_transcript 1.317769 0.9139009 1.340156 0.118669 0.08054018 0.5473162 0.09767846 0.07304257 0.05348913 0.01410108 0.016205341 -0.3873415 0.07421250 0.07916667 0.0387000 -0.04046667 5.770304e-01 8.822455e-06   FALSE
ENST00000601902 ENSG00000197016 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF470 protein_coding protein_coding 1.317769 0.9139009 1.340156 0.118669 0.08054018 0.5473162 0.38641223 0.53737458 0.23394869 0.07744662 0.001963666 -1.1659507 0.30873750 0.58603333 0.1760333 -0.41000000 8.822455e-06 8.822455e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197016 E001 1.732783 0.0080720222 8.058837e-01 8.766033e-01 19 56567468 56567525 58 + 0.411 0.460 0.258
ENSG00000197016 E002 2.220628 0.0074404071 2.716575e-01 4.104322e-01 19 56567526 56567648 123 + 0.568 0.382 -0.936
ENSG00000197016 E003 11.152546 0.0089374256 2.264311e-01 3.581380e-01 19 56567649 56568038 390 + 1.019 1.152 0.481
ENSG00000197016 E004 8.661822 0.0020761075 1.818670e-01 3.035690e-01 19 56568758 56568883 126 + 0.902 1.056 0.572
ENSG00000197016 E005 0.000000       19 56570175 56570279 105 +      
ENSG00000197016 E006 8.217860 0.0035292599 2.893418e-01 4.300316e-01 19 56570280 56570371 92 + 0.889 1.018 0.483
ENSG00000197016 E007 11.032906 0.0017088464 2.277982e-01 3.597924e-01 19 56574394 56574520 127 + 1.009 1.137 0.464
ENSG00000197016 E008 5.023188 0.0035414215 9.477088e-01 9.711113e-01 19 56574638 56574646 9 + 0.758 0.757 -0.003
ENSG00000197016 E009 9.054014 0.0021749973 3.983871e-01 5.421267e-01 19 56574647 56574733 87 + 0.937 1.037 0.372
ENSG00000197016 E010 100.674632 0.0005906102 6.645737e-13 1.679133e-11 19 56576713 56582549 5837 + 2.045 1.867 -0.600
ENSG00000197016 E011 4.872097 0.1816757329 1.360863e-01 2.425981e-01 19 56582550 56582893 344 + 0.593 0.959 1.473
ENSG00000197016 E012 0.000000       19 56582894 56582894 1 +      
ENSG00000197016 E013 0.000000       19 56582895 56582895 1 +      
ENSG00000197016 E014 0.147249 0.0444611506 1.000000e+00   19 56584020 56584112 93 + 0.088 0.000 -8.074
ENSG00000197016 E015 2.138108 0.0080660094 7.271671e-02 1.478679e-01 19 56586635 56588225 1591 + 0.327 0.634 1.554
ENSG00000197016 E016 5.203554 0.0032290840 1.195650e-03 4.625815e-03 19 56588226 56588406 181 + 0.568 0.998 1.729
ENSG00000197016 E017 7.113668 0.0025711826 2.439466e-09 3.364513e-08 19 56588407 56588908 502 + 0.481 1.206 2.896
ENSG00000197016 E018 0.000000       19 56588909 56588911 3 +