ENSG00000197008

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307355 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding protein_coding 8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 0.6103070 0.18354975 1.4735003 0.10781545 0.3405269 2.9382288 0.06913750 0.02350000 0.15863333 0.13513333 3.669205e-02 5.125036e-09 FALSE TRUE
ENST00000359735 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding protein_coding 8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 0.4775905 0.18659961 1.1868014 0.06851659 0.1323610 2.6058514 0.05023750 0.02403333 0.12896667 0.10493333 4.633760e-04 5.125036e-09 FALSE TRUE
ENST00000430838 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding processed_transcript 8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 1.3006567 0.21330034 0.5722142 0.21330034 0.1188090 1.3825646 0.13121250 0.02763333 0.06073333 0.03310000 3.122957e-01 5.125036e-09 FALSE TRUE
ENST00000440155 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding protein_coding 8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 1.2529839 0.53087968 2.2456559 0.28052449 0.2295204 2.0601674 0.12743750 0.07070000 0.24210000 0.17140000 4.582081e-02 5.125036e-09 FALSE TRUE
ENST00000440598 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding protein_coding 8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 0.9331812 0.02656439 0.8080561 0.02656439 0.1473107 4.4836889 0.09932917 0.00330000 0.08526667 0.08196667 4.718482e-08 5.125036e-09 FALSE TRUE
MSTRG.29914.2 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding   8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 1.9435667 4.42945440 0.8976523 0.05515800 0.2838011 -2.2901708 0.27540417 0.57610000 0.09763333 -0.47846667 5.125036e-09 5.125036e-09 FALSE FALSE
MSTRG.29914.4 ENSG00000197008 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF138 protein_coding   8.499256 7.701809 9.350832 0.2250007 0.5322544 0.2795675 1.0055721 1.85164598 0.9260121 0.40542505 0.5675674 -0.9919797 0.13829583 0.23783333 0.09313333 -0.14470000 1.656018e-01 5.125036e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197008 E001 1.6564959 0.0088603882 4.256378e-01 5.685505e-01 7 64794388 64794415 28 + 0.382 0.448 0.358
ENSG00000197008 E002 2.0940903 0.0076416974 8.359158e-01 8.974066e-01 7 64794416 64794416 1 + 0.493 0.448 -0.227
ENSG00000197008 E003 4.9975261 0.0033486538 4.628784e-02 1.025589e-01 7 64794417 64794424 8 + 0.698 0.864 0.662
ENSG00000197008 E004 4.9975261 0.0033486538 4.628784e-02 1.025589e-01 7 64794425 64794427 3 + 0.698 0.864 0.662
ENSG00000197008 E005 19.6675385 0.0032622458 3.011019e-08 3.387946e-07 7 64794428 64794489 62 + 1.158 1.475 1.108
ENSG00000197008 E006 38.3650221 0.0021627158 4.410238e-12 9.719711e-11 7 64794490 64794571 82 + 1.461 1.734 0.928
ENSG00000197008 E007 8.8968758 0.1252493044 1.173362e-04 6.016456e-04 7 64796980 64797108 129 + 0.655 1.259 2.287
ENSG00000197008 E008 27.9631538 0.0110821673 8.976620e-31 1.595304e-28 7 64799191 64799478 288 + 0.930 1.775 2.962
ENSG00000197008 E009 0.8889184 0.0136968632 5.143808e-01 6.490992e-01 7 64814059 64814147 89 + 0.337 0.162 -1.381
ENSG00000197008 E010 26.4434680 0.0009198594 3.861934e-02 8.848208e-02 7 64814918 64815044 127 + 1.508 1.237 -0.943
ENSG00000197008 E011 2.6456388 0.0142257617 1.629154e-02 4.336771e-02 7 64815572 64815575 4 + 0.698 0.162 -3.146
ENSG00000197008 E012 12.1015409 0.0015113282 5.242963e-03 1.659268e-02 7 64815576 64815653 78 + 1.230 0.807 -1.561
ENSG00000197008 E013 3.8968055 0.0043510738 6.420212e-01 7.549314e-01 7 64820220 64820323 104 + 0.737 0.569 -0.721
ENSG00000197008 E014 7.2407128 0.0114527558 7.420738e-02 1.502733e-01 7 64830940 64831076 137 + 1.017 0.663 -1.383
ENSG00000197008 E015 240.2453934 0.0133532191 1.092272e-16 4.673161e-15 7 64831451 64833681 2231 + 2.482 2.098 -1.283