ENSG00000197006

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358154 ENSG00000197006 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL9 protein_coding protein_coding 55.39694 39.11011 76.39464 8.143651 2.430554 0.9657497 5.603208 5.105321 9.379756 0.4763078 0.1628439 0.8762629 0.10382083 0.13660000 0.12306667 -0.01353333 0.834324364 0.007219016 FALSE  
ENST00000396014 ENSG00000197006 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL9 protein_coding protein_coding 55.39694 39.11011 76.39464 8.143651 2.430554 0.9657497 9.463558 5.556971 13.792493 1.7694349 0.6875496 1.3099645 0.17042083 0.13640000 0.18036667 0.04396667 0.315754304 0.007219016 FALSE  
ENST00000567404 ENSG00000197006 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL9 protein_coding protein_coding 55.39694 39.11011 76.39464 8.143651 2.430554 0.9657497 31.538843 23.538157 39.600933 5.0041620 1.5586055 0.7502845 0.56881250 0.60110000 0.51823333 -0.08286667 0.007219016 0.007219016 FALSE  
MSTRG.12230.3 ENSG00000197006 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL9 protein_coding   55.39694 39.11011 76.39464 8.143651 2.430554 0.9657497 3.662227 2.294685 5.879623 0.4050474 0.7546441 1.3536057 0.06500833 0.05946667 0.07683333 0.01736667 0.473231477 0.007219016 TRUE  
MSTRG.12230.6 ENSG00000197006 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL9 protein_coding   55.39694 39.11011 76.39464 8.143651 2.430554 0.9657497 3.330776 1.821386 6.175325 0.3848798 1.3232656 1.7559134 0.05731250 0.04763333 0.08130000 0.03366667 0.395588306 0.007219016 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197006 E001 0.0000000       16 21597218 21597221 4 +      
ENSG00000197006 E002 0.1482932 0.0411597534 2.824039e-01   16 21597222 21597300 79 + 0.000 0.155 10.469
ENSG00000197006 E003 0.0000000       16 21597987 21598007 21 +      
ENSG00000197006 E004 3.8718014 0.0845925464 9.235165e-02 1.787922e-01 16 21599558 21599576 19 + 0.789 0.437 -1.568
ENSG00000197006 E005 5.7216444 0.0369021999 5.183083e-02 1.124211e-01 16 21599577 21599591 15 + 0.922 0.605 -1.284
ENSG00000197006 E006 32.9128013 0.0143483152 1.990752e-09 2.788068e-08 16 21599592 21599613 22 + 1.678 1.088 -2.052
ENSG00000197006 E007 108.9334883 0.0087909635 9.093613e-10 1.358642e-08 16 21599614 21599717 104 + 2.153 1.771 -1.283
ENSG00000197006 E008 187.5752693 0.0050211086 1.329476e-07 1.319012e-06 16 21599718 21599828 111 + 2.353 2.110 -0.812
ENSG00000197006 E009 197.6462762 0.0003548580 4.602187e-16 1.815262e-14 16 21599829 21599898 70 + 2.371 2.152 -0.731
ENSG00000197006 E010 0.3729606 0.0482500794 6.796465e-01 7.837640e-01 16 21600390 21600467 78 + 0.095 0.156 0.817
ENSG00000197006 E011 0.1482932 0.0411597534 2.824039e-01   16 21612100 21612298 199 + 0.000 0.155 12.443
ENSG00000197006 E012 209.4513424 0.0002201104 1.095300e-09 1.612287e-08 16 21612645 21612699 55 + 2.376 2.226 -0.501
ENSG00000197006 E013 389.2448553 0.0001497860 6.296898e-02 1.316582e-01 16 21612700 21612835 136 + 2.602 2.577 -0.084
ENSG00000197006 E014 285.2372800 0.0001803741 2.682561e-01 4.066969e-01 16 21617865 21617897 33 + 2.464 2.449 -0.049
ENSG00000197006 E015 632.6173953 0.0001418060 9.909999e-01 9.985000e-01 16 21617898 21618074 177 + 2.799 2.807 0.027
ENSG00000197006 E016 628.7621281 0.0001108399 1.750805e-02 4.605965e-02 16 21624931 21625115 185 + 2.782 2.823 0.137
ENSG00000197006 E017 1.0308689 0.0130808940 6.455030e-01 7.575944e-01 16 21625116 21625233 118 + 0.348 0.270 -0.512
ENSG00000197006 E018 6.6093566 0.0132347349 9.177554e-04 3.676903e-03 16 21651869 21655226 3358 + 0.647 1.085 1.701
ENSG00000197006 E019 165.0426194 0.0002101419 1.363259e-01 2.429315e-01 16 21655227 21655229 3 + 2.199 2.249 0.168
ENSG00000197006 E020 1117.5930902 0.0008439538 4.758326e-13 1.229474e-11 16 21655230 21655841 612 + 2.999 3.108 0.360
ENSG00000197006 E021 330.1292070 0.0001541137 1.737560e-03 6.400457e-03 16 21655842 21656684 843 + 2.490 2.560 0.232
ENSG00000197006 E022 213.6845783 0.0032945491 2.844469e-02 6.890030e-02 16 21656685 21657471 787 + 2.295 2.370 0.250