ENSG00000196961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354293 ENSG00000196961 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2A1 protein_coding protein_coding 49.55284 74.83937 28.02168 5.190854 0.4401541 -1.416932 44.49133 70.196 23.25577 4.313095 0.6594193 -1.593385 0.88455 0.9392 0.8296 -0.1096 0.0002835072 2.71855e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196961 E001 2.3843601 0.1108416889 1.354973e-02 3.719633e-02 19 49766988 49766989 2 + 0.794 0.321 -2.254
ENSG00000196961 E002 9.8897944 0.0717316103 2.693343e-02 6.585430e-02 19 49766990 49767000 11 + 1.191 0.861 -1.213
ENSG00000196961 E003 16.8405073 0.0163324382 4.466187e-02 9.957816e-02 19 49767001 49767006 6 + 1.317 1.107 -0.744
ENSG00000196961 E004 271.5472251 0.0059583507 2.101856e-03 7.539484e-03 19 49767007 49767133 127 + 2.440 2.311 -0.430
ENSG00000196961 E005 171.7178808 0.0065952851 4.506609e-04 1.969103e-03 19 49767134 49767135 2 + 2.268 2.102 -0.556
ENSG00000196961 E006 298.8379569 0.0070492850 3.900616e-03 1.286468e-02 19 49767136 49767200 65 + 2.481 2.354 -0.424
ENSG00000196961 E007 343.9595790 0.0051429263 5.445177e-02 1.170472e-01 19 49781757 49781825 69 + 2.503 2.428 -0.249
ENSG00000196961 E008 203.2446630 0.0042321686 4.664982e-01 6.060295e-01 19 49781947 49781970 24 + 2.240 2.211 -0.098
ENSG00000196961 E009 345.8493893 0.0007868865 1.782690e-03 6.544301e-03 19 49781971 49782089 119 + 2.506 2.427 -0.262
ENSG00000196961 E010 467.9649663 0.0016895641 8.186379e-04 3.326081e-03 19 49782531 49782724 194 + 2.643 2.557 -0.289
ENSG00000196961 E011 390.5475245 0.0003761569 1.250740e-04 6.370109e-04 19 49791935 49792064 130 + 2.563 2.477 -0.285
ENSG00000196961 E012 266.8989057 0.0001984132 1.625445e-06 1.289243e-05 19 49792991 49793035 45 + 2.424 2.303 -0.406
ENSG00000196961 E013 321.9640059 0.0007943793 2.519255e-05 1.526224e-04 19 49793036 49793092 57 + 2.498 2.389 -0.363
ENSG00000196961 E014 352.1234523 0.0001850262 1.216374e-04 6.212950e-04 19 49795630 49795718 89 + 2.519 2.432 -0.288
ENSG00000196961 E015 181.2256485 0.0002252070 7.669135e-02 1.541991e-01 19 49795719 49795738 20 + 2.207 2.152 -0.186
ENSG00000196961 E016 7.4186353 0.0836953770 4.966514e-04 2.147222e-03 19 49796103 49797562 1460 + 1.239 0.620 -2.367
ENSG00000196961 E017 472.4023194 0.0004404343 1.034276e-02 2.961123e-02 19 49798802 49798952 151 + 2.620 2.567 -0.179
ENSG00000196961 E018 534.2937411 0.0005850058 7.999535e-03 2.377870e-02 19 49799327 49799495 169 + 2.675 2.621 -0.180
ENSG00000196961 E019 537.3236627 0.0003343322 3.037709e-02 7.270630e-02 19 49799629 49799766 138 + 2.667 2.625 -0.139
ENSG00000196961 E020 366.9494148 0.0008598165 7.844970e-02 1.569997e-01 19 49799968 49800017 50 + 2.506 2.463 -0.146
ENSG00000196961 E021 410.1100322 0.0006577241 8.504293e-01 9.072111e-01 19 49800018 49800096 79 + 2.522 2.518 -0.012
ENSG00000196961 E022 364.4245376 0.0011817050 6.307178e-01 7.458575e-01 19 49800097 49800150 54 + 2.457 2.472 0.049
ENSG00000196961 E023 6.9917131 0.0026329470 1.132048e-09 1.661989e-08 19 49800692 49800960 269 + 1.265 0.551 -2.769
ENSG00000196961 E024 302.5695048 0.0002169412 6.978351e-01 7.978735e-01 19 49800961 49800999 39 + 2.381 2.390 0.032
ENSG00000196961 E025 340.1367142 0.0003711766 1.852529e-01 3.078076e-01 19 49801000 49801058 59 + 2.411 2.444 0.110
ENSG00000196961 E026 217.4893102 0.0018047976 5.826128e-01 7.069382e-01 19 49801390 49801402 13 + 2.229 2.249 0.069
ENSG00000196961 E027 438.8032241 0.0018866044 1.679421e-02 4.448315e-02 19 49801403 49801546 144 + 2.492 2.564 0.242
ENSG00000196961 E028 268.2028000 0.0001740707 3.908423e-03 1.288706e-02 19 49801547 49801621 75 + 2.271 2.349 0.261
ENSG00000196961 E029 2.4616491 0.0551337269 3.839199e-01 5.281299e-01 19 49801622 49801721 100 + 0.591 0.425 -0.806
ENSG00000196961 E030 422.8647747 0.0001393682 2.488648e-03 8.729898e-03 19 49801722 49801889 168 + 2.478 2.543 0.217
ENSG00000196961 E031 433.5101797 0.0006334728 1.418477e-02 3.864507e-02 19 49801981 49802141 161 + 2.493 2.553 0.199
ENSG00000196961 E032 2.6022087 0.1500041388 3.004078e-04 1.381229e-03 19 49802142 49802521 380 + 0.933 0.194 -3.748
ENSG00000196961 E033 0.6696487 0.0262580511 3.442417e-02 8.056974e-02 19 49802522 49802533 12 + 0.438 0.073 -3.252
ENSG00000196961 E034 0.9684132 0.0167187639 2.486320e-03 8.723380e-03 19 49802534 49802599 66 + 0.591 0.073 -3.990
ENSG00000196961 E035 7.2287436 0.0023740848 4.199644e-03 1.370229e-02 19 49802600 49802948 349 + 1.080 0.731 -1.332
ENSG00000196961 E036 314.2136149 0.0001678531 1.911470e-01 3.151658e-01 19 49802949 49803005 57 + 2.376 2.408 0.107
ENSG00000196961 E037 0.8888167 0.0849866157 1.868355e-01 3.097580e-01 19 49803006 49803106 101 + 0.438 0.187 -1.690
ENSG00000196961 E038 427.3534877 0.0001533691 5.447874e-02 1.170890e-01 19 49803107 49803189 83 + 2.504 2.545 0.136
ENSG00000196961 E039 4.2771439 0.0487124383 8.345351e-01 8.964284e-01 19 49803190 49803286 97 + 0.591 0.639 0.208
ENSG00000196961 E040 446.7826521 0.0001913556 1.793335e-06 1.409484e-05 19 49803287 49803376 90 + 2.471 2.575 0.346
ENSG00000196961 E041 12.9011218 0.0019533047 1.131582e-02 3.191812e-02 19 49803377 49803453 77 + 1.237 0.982 -0.921
ENSG00000196961 E042 26.8721886 0.0010793923 5.908782e-16 2.301400e-14 19 49803454 49804540 1087 + 1.717 1.162 -1.918
ENSG00000196961 E043 20.2545516 0.0009060913 5.244698e-12 1.142585e-10 19 49804876 49805452 577 + 1.595 1.064 -1.856
ENSG00000196961 E044 262.0641900 0.0004234842 3.782114e-06 2.767837e-05 19 49805453 49805454 2 + 2.214 2.349 0.454
ENSG00000196961 E045 474.1499380 0.0001682333 1.802666e-09 2.546868e-08 19 49805455 49805576 122 + 2.475 2.603 0.426
ENSG00000196961 E046 1.6962643 0.0078474003 7.622983e-04 3.122962e-03 19 49805577 49805585 9 + 0.752 0.190 -3.085
ENSG00000196961 E047 2.1683010 0.0079100703 2.312046e-04 1.096698e-03 19 49805586 49805660 75 + 0.833 0.238 -2.992
ENSG00000196961 E048 389.7400614 0.0005174697 1.288745e-05 8.344685e-05 19 49805661 49805724 64 + 2.407 2.516 0.365
ENSG00000196961 E049 392.6358447 0.0002135236 4.484577e-05 2.555926e-04 19 49805725 49805777 53 + 2.422 2.517 0.314
ENSG00000196961 E050 6.0550005 0.0026791725 7.637552e-08 7.933933e-07 19 49805778 49805871 94 + 1.191 0.528 -2.613
ENSG00000196961 E051 453.4402917 0.0016716681 6.006679e-04 2.535590e-03 19 49805872 49805941 70 + 2.482 2.583 0.336
ENSG00000196961 E052 2.2141822 0.0186844688 1.056183e-02 3.011601e-02 19 49805942 49806118 177 + 0.752 0.321 -2.087
ENSG00000196961 E053 688.1747259 0.0037012675 1.854374e-03 6.771372e-03 19 49806119 49806253 135 + 2.658 2.766 0.359
ENSG00000196961 E054 30.6144090 0.0158948627 4.430610e-04 1.940102e-03 19 49806254 49806680 427 + 1.638 1.326 -1.071
ENSG00000196961 E055 723.4365180 0.0036042550 3.001678e-07 2.777740e-06 19 49806681 49807114 434 + 2.624 2.799 0.582