ENSG00000196922

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426361 ENSG00000196922 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF252P transcribed_unprocessed_pseudogene processed_transcript 5.463405 1.582068 9.266291 0.02674388 0.465603 2.542646 2.48400513 0.79914194 4.13525584 0.10585592 0.06215391 2.356996 0.48972917 0.50366667 0.447933333 -0.05573333 0.69155168 0.0207021 FALSE TRUE
ENST00000427606 ENSG00000196922 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF252P transcribed_unprocessed_pseudogene processed_transcript 5.463405 1.582068 9.266291 0.02674388 0.465603 2.542646 0.77561333 0.08911067 1.29970816 0.02703788 0.11652402 3.724061 0.11009167 0.05663333 0.140466667 0.08383333 0.07599819 0.0207021 FALSE TRUE
ENST00000529315 ENSG00000196922 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF252P transcribed_unprocessed_pseudogene processed_transcript 5.463405 1.582068 9.266291 0.02674388 0.465603 2.542646 0.08642158 0.10225415 0.08292629 0.10225415 0.04157422 -0.272610 0.03080833 0.06680000 0.008533333 -0.05826667 0.90459164 0.0207021   FALSE
ENST00000534037 ENSG00000196922 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF252P transcribed_unprocessed_pseudogene processed_transcript 5.463405 1.582068 9.266291 0.02674388 0.465603 2.542646 0.81779389 0.34353057 1.15252195 0.09011913 0.14476109 1.717351 0.16670833 0.21636667 0.123533333 -0.09283333 0.29307135 0.0207021   FALSE
ENST00000690545 ENSG00000196922 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF252P transcribed_unprocessed_pseudogene processed_transcript 5.463405 1.582068 9.266291 0.02674388 0.465603 2.542646 0.84603287 0.15519273 2.03791291 0.02182743 0.14255362 3.631932 0.11879583 0.09780000 0.219900000 0.12210000 0.02070210 0.0207021 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196922 E001 102.7955044 0.0240892278 3.483944e-06 2.571283e-05 8 144973589 144975189 1601 - 1.787 2.194 1.368
ENSG00000196922 E002 24.3268934 0.0038284702 2.489430e-02 6.165628e-02 8 144975190 144975249 60 - 1.226 1.480 0.881
ENSG00000196922 E003 87.6708600 0.0010752532 2.666311e-01 4.048607e-01 8 144975250 144976189 940 - 1.790 1.905 0.385
ENSG00000196922 E004 41.0277790 0.0008060533 4.000288e-02 9.104307e-02 8 144976190 144976624 435 - 1.501 1.402 -0.340
ENSG00000196922 E005 15.7302706 0.0109436632 1.890968e-03 6.886546e-03 8 144976625 144976684 60 - 1.136 0.715 -1.597
ENSG00000196922 E006 35.6434398 0.0006251514 2.525178e-03 8.838077e-03 8 144976685 144976938 254 - 1.453 1.248 -0.712
ENSG00000196922 E007 17.7615419 0.0011283427 7.531987e-02 1.520321e-01 8 144976939 144976947 9 - 1.159 1.008 -0.548
ENSG00000196922 E008 15.9333420 0.0013003776 5.041725e-02 1.099087e-01 8 144976948 144976950 3 - 1.120 0.930 -0.694
ENSG00000196922 E009 15.9269993 0.0012621526 5.037856e-02 1.098357e-01 8 144976951 144976951 1 - 1.120 0.930 -0.694
ENSG00000196922 E010 87.4028231 0.0003659463 6.223520e-04 2.614599e-03 8 144976952 144977753 802 - 1.826 1.709 -0.398
ENSG00000196922 E011 85.5821274 0.0003567650 1.280125e-06 1.039145e-05 8 144977754 144978553 800 - 1.825 1.614 -0.714
ENSG00000196922 E012 25.8491030 0.0026995475 4.545362e-01 5.951668e-01 8 144994479 144994592 114 - 1.299 1.287 -0.040
ENSG00000196922 E013 24.6045777 0.0008486003 2.873571e-02 6.947552e-02 8 144994593 144995717 1125 - 1.296 1.131 -0.582
ENSG00000196922 E014 22.4972342 0.0303959158 3.976254e-01 5.413817e-01 8 144995718 144996451 734 - 1.248 1.181 -0.236
ENSG00000196922 E015 4.1165663 0.0661704349 1.586706e-01 2.733616e-01 8 144996452 144996506 55 - 0.533 0.837 1.282
ENSG00000196922 E016 21.0008586 0.0009850206 1.290177e-02 3.568387e-02 8 144996507 144996607 101 - 1.152 1.430 0.974
ENSG00000196922 E017 0.1472490 0.0434330701 1.000000e+00   8 144997982 144999602 1621 - 0.052 0.001 -6.365
ENSG00000196922 E018 26.1141742 0.0008257218 3.398098e-01 4.837328e-01 8 144999603 144999769 167 - 1.276 1.416 0.488
ENSG00000196922 E019 0.9609246 0.0132090874 2.630810e-01 4.009417e-01 8 144999911 145000159 249 - 0.178 0.427 1.721
ENSG00000196922 E020 0.7395785 0.1921515366 1.258711e-01 2.283894e-01 8 145000352 145000538 187 - 0.098 0.434 2.756
ENSG00000196922 E021 1.1115096 0.0637849562 1.000000e+00 1.000000e+00 8 145002793 145002816 24 - 0.246 0.265 0.142
ENSG00000196922 E022 11.1630016 0.0016559920 1.783677e-01 2.990930e-01 8 145002817 145002912 96 - 0.915 1.131 0.795