ENSG00000196914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356641 ENSG00000196914 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF12 protein_coding protein_coding 13.85412 6.720816 20.74959 0.7975689 0.5175294 1.624925 9.1088069 5.03385007 12.501355 0.64608948 0.6544980 1.310641 0.66930417 0.754200000 0.6018000 -0.15240000 3.672154e-01 1.510848e-26 FALSE TRUE
ENST00000397843 ENSG00000196914 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF12 protein_coding protein_coding 13.85412 6.720816 20.74959 0.7975689 0.5175294 1.624925 1.2462451 0.86805798 1.765319 0.43657981 0.5967467 1.015690 0.11232917 0.118333333 0.0866000 -0.03173333 8.074524e-01 1.510848e-26 FALSE TRUE
ENST00000532993 ENSG00000196914 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF12 protein_coding protein_coding 13.85412 6.720816 20.74959 0.7975689 0.5175294 1.624925 0.3181259 0.49161801 0.000000 0.49161801 0.0000000 -5.648517 0.04077917 0.081400000 0.0000000 -0.08140000 6.317068e-01 1.510848e-26 FALSE TRUE
MSTRG.6464.1 ENSG00000196914 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF12 protein_coding   13.85412 6.720816 20.74959 0.7975689 0.5175294 1.624925 2.2011602 0.03863582 5.142444 0.01951631 0.2047762 6.727094 0.11317500 0.005566667 0.2479333 0.24236667 1.510848e-26 1.510848e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196914 E001 7.3348316 0.0283017416 6.537236e-03 2.002141e-02 11 120336342 120336412 71 + 0.911 0.559 -1.450
ENSG00000196914 E002 14.8065557 0.0056800117 2.922252e-04 1.348169e-03 11 120336413 120336463 51 + 1.180 0.877 -1.115
ENSG00000196914 E003 30.6089464 0.0218959007 1.977757e-05 1.227936e-04 11 120336464 120336649 186 + 1.486 1.149 -1.177
ENSG00000196914 E004 44.9035895 0.0171269900 4.065815e-06 2.951966e-05 11 120336650 120336913 264 + 1.643 1.341 -1.040
ENSG00000196914 E005 95.0812712 0.0032290946 2.275480e-10 3.773154e-09 11 120336914 120337275 362 + 1.948 1.747 -0.677
ENSG00000196914 E006 0.0000000       11 120385294 120385320 27 +      
ENSG00000196914 E007 0.0000000       11 120385321 120385486 166 +      
ENSG00000196914 E008 1.0351233 0.0119544876 8.367915e-02 1.653131e-01 11 120405933 120406117 185 + 0.330 0.000 -21.762
ENSG00000196914 E009 36.5472146 0.0308680691 3.153364e-03 1.071717e-02 11 120406118 120406141 24 + 1.536 1.358 -0.612
ENSG00000196914 E010 54.1261493 0.0069266197 4.180119e-08 4.580963e-07 11 120407738 120407823 86 + 1.716 1.445 -0.928
ENSG00000196914 E011 0.3332198 0.0283802064 4.392111e-01   11 120407824 120409393 1570 + 0.065 0.218 2.004
ENSG00000196914 E012 14.2318685 0.0205163709 3.390641e-03 1.141057e-02 11 120409394 120409450 57 + 1.161 0.912 -0.912
ENSG00000196914 E013 0.0000000       11 120409451 120411837 2387 +      
ENSG00000196914 E014 2.7839277 0.0258081114 3.863510e-01 5.305458e-01 11 120417529 120417657 129 + 0.536 0.471 -0.318
ENSG00000196914 E015 60.0255198 0.0004151619 1.158304e-10 2.023022e-09 11 120420753 120420851 99 + 1.756 1.518 -0.811
ENSG00000196914 E016 46.2011455 0.0006159362 8.913502e-07 7.481110e-06 11 120421803 120421852 50 + 1.634 1.453 -0.620
ENSG00000196914 E017 46.8767852 0.0005982427 8.240342e-08 8.507280e-07 11 120424358 120424415 58 + 1.646 1.433 -0.729
ENSG00000196914 E018 84.1744733 0.0003338158 1.604836e-10 2.734833e-09 11 120428069 120428247 179 + 1.889 1.720 -0.568
ENSG00000196914 E019 62.7731265 0.0005947807 4.000544e-09 5.305874e-08 11 120429440 120429517 78 + 1.768 1.574 -0.660
ENSG00000196914 E020 44.3616072 0.0058502511 9.124240e-03 2.659377e-02 11 120429712 120429831 120 + 1.595 1.544 -0.173
ENSG00000196914 E021 68.1955454 0.0010639352 1.615393e-09 2.304106e-08 11 120431771 120431911 141 + 1.805 1.610 -0.661
ENSG00000196914 E022 66.1287471 0.0164044520 7.875090e-05 4.220999e-04 11 120437308 120437382 75 + 1.789 1.613 -0.596
ENSG00000196914 E023 2.1872274 0.0108583067 1.751219e-01 2.948427e-01 11 120438448 120440128 1681 + 0.362 0.691 1.586
ENSG00000196914 E024 67.6788194 0.0003790684 9.154265e-09 1.136765e-07 11 120440129 120440221 93 + 1.798 1.631 -0.566
ENSG00000196914 E025 68.8333853 0.0009405689 1.002171e-06 8.312536e-06 11 120441707 120441817 111 + 1.795 1.675 -0.408
ENSG00000196914 E026 72.8905091 0.0003609603 7.258346e-10 1.104878e-08 11 120442104 120442202 99 + 1.830 1.650 -0.609
ENSG00000196914 E027 52.9706248 0.0016833566 7.669567e-07 6.532760e-06 11 120445422 120445464 43 + 1.691 1.518 -0.589
ENSG00000196914 E028 83.2921100 0.0055042642 1.777690e-06 1.398348e-05 11 120446403 120446508 106 + 1.881 1.733 -0.498
ENSG00000196914 E029 97.4584473 0.0003310909 5.928390e-09 7.638684e-08 11 120446948 120447085 138 + 1.943 1.829 -0.384
ENSG00000196914 E030 0.6028395 0.4650094126 9.199879e-01 9.534562e-01 11 120447086 120447266 181 + 0.174 0.214 0.374
ENSG00000196914 E031 54.5554557 0.0004647548 1.119267e-03 4.367851e-03 11 120447874 120447906 33 + 1.681 1.637 -0.148
ENSG00000196914 E032 76.9244074 0.0012645596 2.581662e-04 1.209148e-03 11 120448234 120448348 115 + 1.827 1.785 -0.140
ENSG00000196914 E033 0.5546650 0.0203382761 1.400786e-01 2.481390e-01 11 120448494 120449108 615 + 0.065 0.363 3.006
ENSG00000196914 E034 72.9934700 0.0003482331 5.803806e-03 1.809661e-02 11 120449109 120449214 106 + 1.794 1.803 0.031
ENSG00000196914 E035 0.5117019 0.0206586898 8.654357e-03 2.541847e-02 11 120449275 120451511 2237 + 0.000 0.470 24.272
ENSG00000196914 E036 111.8728782 0.0025284734 1.789402e-03 6.565507e-03 11 120451512 120451724 213 + 1.978 1.978 0.002
ENSG00000196914 E037 0.0000000       11 120457051 120457117 67 +      
ENSG00000196914 E038 101.0375088 0.0005458746 1.288714e-05 8.344685e-05 11 120457118 120457250 133 + 1.943 1.899 -0.149
ENSG00000196914 E039 0.0000000       11 120457251 120457717 467 +      
ENSG00000196914 E040 0.5244761 0.3092126406 7.270205e-01 8.198953e-01 11 120457718 120457720 3 + 0.123 0.222 1.028
ENSG00000196914 E041 64.2796821 0.0003664509 1.937877e-04 9.372368e-04 11 120457721 120457756 36 + 1.753 1.698 -0.185
ENSG00000196914 E042 0.1472490 0.0434588009 1.000000e+00   11 120457757 120458079 323 + 0.065 0.000 -18.955
ENSG00000196914 E043 108.2745056 0.0003275992 2.112636e-07 2.015879e-06 11 120458080 120458234 155 + 1.980 1.909 -0.238
ENSG00000196914 E044 0.1451727 0.0434152664 1.000000e+00   11 120458235 120459173 939 + 0.065 0.000 -18.955
ENSG00000196914 E045 88.5382276 0.0125534507 9.073770e-02 1.762967e-01 11 120459174 120459320 147 + 1.871 1.904 0.113
ENSG00000196914 E046 0.0000000       11 120459321 120459339 19 +      
ENSG00000196914 E047 66.6023496 0.0013898988 4.655963e-02 1.030490e-01 11 120460672 120460757 86 + 1.748 1.785 0.128
ENSG00000196914 E048 0.5149242 0.1114995808 1.656967e-01 2.826034e-01 11 120462549 120465236 2688 + 0.065 0.363 3.007
ENSG00000196914 E049 84.7109532 0.0003764922 2.274669e-02 5.722527e-02 11 120465237 120465362 126 + 1.847 1.888 0.137
ENSG00000196914 E050 85.0411105 0.0075004527 5.904049e-04 2.498614e-03 11 120467194 120467308 115 + 1.877 1.812 -0.217
ENSG00000196914 E051 83.2166460 0.0007488656 6.505271e-04 2.717839e-03 11 120469288 120469388 101 + 1.858 1.841 -0.057
ENSG00000196914 E052 67.5838459 0.0079483845 5.449044e-01 6.753175e-01 11 120473050 120473127 78 + 1.740 1.840 0.340
ENSG00000196914 E053 67.5643999 0.0103528591 2.022921e-01 3.290909e-01 11 120474560 120474635 76 + 1.753 1.802 0.166
ENSG00000196914 E054 105.7878369 0.0012171678 6.759215e-02 1.393513e-01 11 120475340 120475507 168 + 1.938 2.004 0.221
ENSG00000196914 E055 0.8148214 0.0240027459 7.803502e-01 8.588368e-01 11 120475975 120476660 686 + 0.217 0.218 0.006
ENSG00000196914 E056 91.1650292 0.0003394876 1.203122e-02 3.360479e-02 11 120476661 120476748 88 + 1.882 1.916 0.115
ENSG00000196914 E057 0.5911862 0.0184515391 2.666331e-01 4.048607e-01 11 120477000 120477218 219 + 0.217 0.000 -20.955
ENSG00000196914 E058 87.8141200 0.0003226792 5.561852e-02 1.190433e-01 11 120477219 120477305 87 + 1.860 1.920 0.200
ENSG00000196914 E059 77.2725091 0.0005925160 1.640133e-02 4.361755e-02 11 120477447 120477526 80 + 1.813 1.842 0.097
ENSG00000196914 E060 5.0165674 0.0073022441 2.483396e-02 6.153499e-02 11 120477527 120477646 120 + 0.575 1.005 1.724
ENSG00000196914 E061 42.3049619 0.0047947594 4.529235e-02 1.007243e-01 11 120478156 120478159 4 + 1.563 1.560 -0.011
ENSG00000196914 E062 82.0334952 0.0026205228 8.770795e-02 1.716530e-01 11 120478160 120478233 74 + 1.831 1.885 0.184
ENSG00000196914 E063 116.6207342 0.0002714991 2.649849e-01 4.029932e-01 11 120478234 120478389 156 + 1.970 2.071 0.339
ENSG00000196914 E064 225.9633626 0.0002062333 1.139862e-01 2.113343e-01 11 120479960 120480430 471 + 2.234 2.418 0.614
ENSG00000196914 E065 183.3691022 0.0002659260 1.239398e-04 6.318798e-04 11 120481260 120481576 317 + 2.120 2.372 0.841
ENSG00000196914 E066 79.1482728 0.0060550921 9.597014e-03 2.777191e-02 11 120484438 120484507 70 + 1.748 2.034 0.962
ENSG00000196914 E067 1485.4731945 0.0159972252 1.340817e-12 3.219846e-11 11 120485067 120489937 4871 + 2.950 3.390 1.462