ENSG00000196912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258459 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding protein_coding 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.34043791 0.16164252 0.61712622 0.08203164 0.07167635 1.8693488 0.3093250 0.2795667 0.33443333 0.05486667 8.533444e-01 5.336728e-05 FALSE TRUE
ENST00000359901 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding protein_coding 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.16962630 0.08101689 0.17405700 0.08101689 0.17405700 1.0159463 0.1226500 0.1329667 0.09176667 -0.04120000 8.955086e-01 5.336728e-05 FALSE TRUE
ENST00000419390 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.26366658 0.06167089 0.39308973 0.06167089 0.12983552 2.4916419 0.1734208 0.1012333 0.21333333 0.11210000 5.618891e-01 5.336728e-05 TRUE FALSE
ENST00000438709 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.16216390 0.07510373 0.05095016 0.05454365 0.05095016 -0.4815924 0.1416583 0.1359667 0.02686667 -0.10910000 4.929305e-01 5.336728e-05 TRUE TRUE
ENST00000443455 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.20396191 0.00000000 0.46103519 0.00000000 0.04597240 5.5577629 0.1289958 0.0000000 0.24503333 0.24503333 5.336728e-05 5.336728e-05 TRUE FALSE
ENST00000488634 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding retained_intron 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.10794569 0.12651006 0.18919987 0.07015967 0.14448107 0.5452094 0.0984375 0.2030667 0.08856667 -0.11450000 7.058845e-01 5.336728e-05 TRUE TRUE
ENST00000615794 ENSG00000196912 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36B protein_coding retained_intron 1.275448 0.6401417 1.885458 0.1486728 0.1802681 1.54372 0.02764565 0.13419762 0.00000000 0.13419762 0.00000000 -3.8499755 0.0254875 0.1472000 0.00000000 -0.14720000 5.416184e-01 5.336728e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196912 E001 0.0000000       2 97492663 97492665 3 -      
ENSG00000196912 E002 0.0000000       2 97492666 97492855 190 -      
ENSG00000196912 E003 0.0000000       2 97504798 97504800 3 -      
ENSG00000196912 E004 0.3666179 0.027996378 0.256372501 0.39332632 2 97504801 97506435 1635 - 0.064 0.223 2.081
ENSG00000196912 E005 0.0000000       2 97506964 97507035 72 -      
ENSG00000196912 E006 0.0000000       2 97507036 97507065 30 -      
ENSG00000196912 E007 0.8020473 0.017903272 0.034965405 0.08158953 2 97507564 97507657 94 - 0.119 0.478 2.663
ENSG00000196912 E008 0.0000000       2 97507658 97507994 337 -      
ENSG00000196912 E009 0.0000000       2 97507995 97508065 71 -      
ENSG00000196912 E010 0.8020473 0.017903272 0.034965405 0.08158953 2 97509581 97509733 153 - 0.119 0.478 2.663
ENSG00000196912 E011 0.6558305 0.021000658 0.139055723 0.24678160 2 97511138 97512052 915 - 0.119 0.369 2.079
ENSG00000196912 E012 3.4582807 0.004956195 0.527031833 0.66019506 2 97513180 97513363 184 - 0.567 0.638 0.314
ENSG00000196912 E013 2.7124586 0.055410064 0.522306505 0.65614470 2 97515732 97515945 214 - 0.485 0.568 0.393
ENSG00000196912 E014 1.6231864 0.009463961 0.834084208 0.89609719 2 97523326 97523467 142 - 0.355 0.369 0.080
ENSG00000196912 E015 2.4629008 0.006386827 0.587048472 0.71044104 2 97532311 97532384 74 - 0.507 0.369 -0.728
ENSG00000196912 E016 2.7595889 0.005816884 0.453716838 0.59445139 2 97536300 97536372 73 - 0.548 0.369 -0.921
ENSG00000196912 E017 1.2147514 0.010741102 0.707676231 0.80551648 2 97536468 97536496 29 - 0.324 0.222 -0.729
ENSG00000196912 E018 1.6544221 0.009132097 0.432141787 0.57459079 2 97538168 97538240 73 - 0.412 0.222 -1.243
ENSG00000196912 E019 1.0203615 0.184860262 0.295179456 0.43631249 2 97538335 97538363 29 - 0.323 0.000 -12.253
ENSG00000196912 E020 1.0246279 0.017076116 0.215339572 0.34482107 2 97540034 97540106 73 - 0.324 0.000 -12.309
ENSG00000196912 E021 1.1718769 0.013514568 0.165212690 0.28196071 2 97540201 97540229 29 - 0.355 0.000 -12.430
ENSG00000196912 E022 2.2176094 0.006563098 0.031212595 0.07431266 2 97541911 97541983 73 - 0.528 0.000 -12.976
ENSG00000196912 E023 1.8520211 0.008133366 0.365245895 0.50957919 2 97542079 97542107 29 - 0.438 0.222 -1.380
ENSG00000196912 E024 2.5132508 0.006592960 0.587440195 0.71072895 2 97543790 97543862 73 - 0.507 0.369 -0.728
ENSG00000196912 E025 2.4433210 0.006346087 0.184947908 0.30742216 2 97543957 97543985 29 - 0.528 0.222 -1.828
ENSG00000196912 E026 3.9234110 0.005320981 0.450275154 0.59139001 2 97545666 97545738 73 - 0.652 0.478 -0.795
ENSG00000196912 E027 2.5130353 0.013273822 0.455586038 0.59610361 2 97545833 97545861 29 - 0.462 0.565 0.494
ENSG00000196912 E028 2.7699826 0.005746056 0.608180368 0.72800077 2 97547536 97547564 29 - 0.507 0.565 0.271
ENSG00000196912 E029 2.7657162 0.007679360 0.609682888 0.72912320 2 97547565 97547608 44 - 0.507 0.565 0.271
ENSG00000196912 E030 2.7960069 0.008555550 0.928643695 0.95909003 2 97547703 97547731 29 - 0.528 0.478 -0.242
ENSG00000196912 E031 3.4311116 0.010729654 0.537438092 0.66899770 2 97549419 97549491 73 - 0.567 0.638 0.313
ENSG00000196912 E032 2.4409405 0.010449656 0.186285636 0.30908709 2 97549586 97549614 29 - 0.438 0.637 0.938
ENSG00000196912 E033 1.8445575 0.008063776 0.187276734 0.31031028 2 97551289 97551311 23 - 0.355 0.565 1.077
ENSG00000196912 E034 2.6206572 0.005692515 0.527077706 0.66023506 2 97551312 97551361 50 - 0.486 0.565 0.378
ENSG00000196912 E035 2.1476770 0.007247375 0.748611980 0.83578762 2 97551452 97551480 29 - 0.462 0.369 -0.507
ENSG00000196912 E036 2.5958806 0.014990499 0.522640639 0.65640879 2 97553168 97553240 73 - 0.528 0.369 -0.829
ENSG00000196912 E037 2.5958806 0.014990499 0.522640639 0.65640879 2 97553343 97553371 29 - 0.528 0.369 -0.829
ENSG00000196912 E038 3.9621473 0.006662738 0.402344338 0.54607633 2 97555060 97555132 73 - 0.667 0.478 -0.860
ENSG00000196912 E039 2.5530192 0.020286100 0.163964688 0.28030806 2 97555226 97555254 29 - 0.548 0.222 -1.922
ENSG00000196912 E040 2.2409040 0.103602384 0.050889859 0.11075289 2 97556937 97557009 73 - 0.529 0.000 -12.943
ENSG00000196912 E041 2.4204183 0.088934833 0.227871671 0.35989066 2 97557104 97557132 29 - 0.529 0.223 -1.831
ENSG00000196912 E042 3.0009953 0.014537371 0.094444824 0.18204681 2 97558799 97558871 73 - 0.603 0.222 -2.170
ENSG00000196912 E043 1.8016711 0.008574194 0.365320879 0.50965003 2 97558966 97558994 29 - 0.438 0.222 -1.381
ENSG00000196912 E044 2.9475118 0.008511956 0.010570427 0.03013870 2 97560665 97560737 73 - 0.620 0.000 -13.219
ENSG00000196912 E045 2.2217620 0.006760474 0.031084131 0.07407032 2 97560832 97560860 29 - 0.528 0.000 -12.976
ENSG00000196912 E046 0.5901540 0.020079170 0.691896768 0.79326168 2 97576379 97576446 68 - 0.169 0.222 0.492
ENSG00000196912 E047 3.3184081 0.004827979 0.624776500 0.74103637 2 97578906 97579043 138 - 0.603 0.478 -0.585
ENSG00000196912 E048 3.9271097 0.090009046 0.496067331 0.63280476 2 97580462 97580568 107 - 0.619 0.696 0.330
ENSG00000196912 E049 7.4782234 0.023750172 0.008978567 0.02622676 2 97584944 97585117 174 - 0.783 1.088 1.151
ENSG00000196912 E050 7.4629747 0.002410563 0.590327896 0.71320244 2 97585284 97585398 115 - 0.856 0.886 0.114
ENSG00000196912 E051 16.5577053 0.001614384 0.101822893 0.19327815 2 97589525 97589877 353 - 1.146 1.248 0.364