ENSG00000196911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356348 ENSG00000196911 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA5 protein_coding protein_coding 8.40045 1.028546 14.05526 0.09301216 0.3491824 3.759498 5.5332438 0.31817073 9.3530641 0.15933286 0.40469324 4.834462 0.54187083 0.2888000 0.66530000 0.37650000 0.2698983896 6.62709e-05 FALSE TRUE
ENST00000368564 ENSG00000196911 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA5 protein_coding protein_coding 8.40045 1.028546 14.05526 0.09301216 0.3491824 3.759498 1.6324616 0.50314901 2.6197275 0.06538932 0.06994797 2.357464 0.33334583 0.4983667 0.18640000 -0.31196667 0.0000662709 6.62709e-05 FALSE TRUE
ENST00000413340 ENSG00000196911 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA5 protein_coding protein_coding 8.40045 1.028546 14.05526 0.09301216 0.3491824 3.759498 0.6890558 0.03620143 1.3996140 0.03620143 0.13576936 4.931219 0.05913333 0.0351000 0.09996667 0.06486667 0.1393962625 6.62709e-05 FALSE FALSE
MSTRG.28862.1 ENSG00000196911 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNA5 protein_coding   8.40045 1.028546 14.05526 0.09301216 0.3491824 3.759498 0.5456893 0.17102513 0.6828511 0.07055051 0.17076838 1.936355 0.06562083 0.1777000 0.04833333 -0.12936667 0.1635721027 6.62709e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196911 E001 1.141699 0.0348105099 1.789163e-01 0.2997872780 6 116680941 116681186 246 + 0.175 0.496 2.102
ENSG00000196911 E002 3.946341 0.0322577236 6.947426e-01 0.7954942030 6 116681187 116681210 24 + 0.530 0.496 -0.161
ENSG00000196911 E003 32.202498 0.0006938808 8.894175e-01 0.9333127465 6 116681211 116681338 128 + 1.301 1.368 0.235
ENSG00000196911 E004 4.004897 0.0040379344 2.084026e-01 0.3365582171 6 116681447 116681552 106 + 0.555 0.315 -1.281
ENSG00000196911 E005 46.833185 0.0005469334 9.077053e-01 0.9454229700 6 116689320 116689453 134 + 1.454 1.545 0.312
ENSG00000196911 E006 44.730831 0.0005293210 6.116914e-02 0.1285918332 6 116692055 116692156 102 + 1.453 1.369 -0.291
ENSG00000196911 E007 45.879027 0.0012609300 7.594308e-02 0.1530158141 6 116692293 116692392 100 + 1.463 1.388 -0.260
ENSG00000196911 E008 47.535087 0.0024136675 5.433860e-02 0.1168410934 6 116698704 116698798 95 + 1.479 1.388 -0.314
ENSG00000196911 E009 52.384274 0.0004879076 1.185134e-01 0.2178157916 6 116702019 116702150 132 + 1.516 1.473 -0.147
ENSG00000196911 E010 35.796497 0.0005787679 3.103199e-02 0.0739793505 6 116705072 116705160 89 + 1.367 1.230 -0.481
ENSG00000196911 E011 2.514181 0.0061605941 3.078183e-01 0.4500537255 6 116715212 116715292 81 + 0.360 0.623 1.305
ENSG00000196911 E012 41.247286 0.0033752759 1.386197e-03 0.0052618985 6 116716219 116716318 100 + 1.431 1.172 -0.907
ENSG00000196911 E013 67.339947 0.0004538679 1.511547e-02 0.0407482009 6 116722126 116722289 164 + 1.626 1.532 -0.323
ENSG00000196911 E014 46.091313 0.0005126506 3.964641e-02 0.0903729265 6 116724297 116724375 79 + 1.468 1.368 -0.343
ENSG00000196911 E015 54.954795 0.0005978445 4.653893e-01 0.6051118332 6 116725751 116725876 126 + 1.531 1.558 0.093
ENSG00000196911 E016 55.473028 0.0005084348 6.856453e-01 0.7883408003 6 116726495 116726622 128 + 1.531 1.583 0.179
ENSG00000196911 E017 62.615088 0.0004260995 3.624001e-03 0.0120789614 6 116729563 116729741 179 + 1.601 1.458 -0.491
ENSG00000196911 E018 81.850431 0.0003985250 1.712189e-02 0.0452107644 6 116732136 116732368 233 + 1.710 1.639 -0.241
ENSG00000196911 E019 291.352166 0.0179450070 4.203277e-05 0.0002410396 6 116732369 116741505 9137 + 2.208 2.503 0.984
ENSG00000196911 E020 19.757229 0.0009945603 4.110026e-05 0.0002362785 6 116741506 116741867 362 + 1.035 1.503 1.648