ENSG00000196876

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355133 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding protein_coding 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.21460633 0.11341503 0.08908565 0.06009524 0.08908565 -0.3167701 0.31774167 0.3072667 0.1064667 -0.2008000 5.942396e-01 5.486101e-06 FALSE TRUE
ENST00000545061 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding protein_coding 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.09177482 0.04866918 0.00000000 0.04866918 0.00000000 -2.5526028 0.10735833 0.1087667 0.0000000 -0.1087667 6.329247e-01 5.486101e-06 FALSE TRUE
ENST00000548086 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding nonsense_mediated_decay 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.08055840 0.02273407 0.12459004 0.02273407 0.06462422 2.0397070 0.09737917 0.0428000 0.1523333 0.1095333 6.635021e-01 5.486101e-06 TRUE TRUE
ENST00000636945 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding nonsense_mediated_decay 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.17514599 0.23069426 0.00000000 0.06805330 0.00000000 -4.5891298 0.22112083 0.5117667 0.0000000 -0.5117667 5.486101e-06 5.486101e-06 FALSE TRUE
ENST00000662684 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding protein_coding 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.01966961 0.00000000 0.14215220 0.00000000 0.09795152 3.9274433 0.02345000 0.0000000 0.1720000 0.1720000 3.786762e-01 5.486101e-06 FALSE TRUE
ENST00000668547 ENSG00000196876 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN8A protein_coding protein_coding 0.7647075 0.4285726 0.7698132 0.06545875 0.0468757 0.830313 0.12839595 0.00000000 0.34758462 0.00000000 0.18561878 5.1602128 0.16724167 0.0000000 0.4828000 0.4828000 3.459933e-01 5.486101e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196876 E001 0.0000000       12 51590266 51590673 408 +      
ENSG00000196876 E002 0.0000000       12 51590879 51590905 27 +      
ENSG00000196876 E003 0.3268771 0.029647724 6.866557e-01   12 51590906 51590924 19 + 0.097 0.154 0.775
ENSG00000196876 E004 0.3268771 0.029647724 6.866557e-01   12 51590925 51590925 1 + 0.097 0.154 0.775
ENSG00000196876 E005 0.4783925 0.021439610 9.279686e-01 9.586489e-01 12 51590926 51590999 74 + 0.175 0.154 -0.226
ENSG00000196876 E006 0.0000000       12 51591224 51591232 9 +      
ENSG00000196876 E007 0.0000000       12 51591233 51591235 3 +      
ENSG00000196876 E008 0.3686942 0.029241332 6.828671e-01 7.862113e-01 12 51591236 51591359 124 + 0.097 0.154 0.777
ENSG00000196876 E009 0.8147077 0.087421445 4.676129e-01 6.071166e-01 12 51662764 51662817 54 + 0.300 0.155 -1.218
ENSG00000196876 E010 1.8488980 0.058487351 5.507795e-01 6.803430e-01 12 51662818 51663093 276 + 0.476 0.360 -0.624
ENSG00000196876 E011 1.5469113 0.102699201 6.666649e-01 7.740772e-01 12 51684174 51684292 119 + 0.351 0.436 0.474
ENSG00000196876 E012 1.2555363 0.011121513 4.932454e-01 6.302745e-01 12 51686368 51686422 55 + 0.397 0.267 -0.811
ENSG00000196876 E013 0.9620705 0.012463944 2.901854e-01 4.309726e-01 12 51686423 51686457 35 + 0.351 0.154 -1.547
ENSG00000196876 E014 2.0818973 0.013467560 6.773549e-01 7.820940e-01 12 51687091 51687219 129 + 0.511 0.432 -0.396
ENSG00000196876 E015 0.7511326 0.622740417 8.409145e-01 9.007203e-01 12 51688758 51688849 92 + 0.244 0.257 0.101
ENSG00000196876 E016 0.2924217 0.027734313 3.967244e-01   12 51688850 51689004 155 + 0.175 0.000 -10.201
ENSG00000196876 E017 2.2217620 0.006539044 4.454654e-04 1.949324e-03 12 51689005 51689096 92 + 0.675 0.000 -12.282
ENSG00000196876 E018 0.6256415 0.017671653 6.314012e-01 7.464055e-01 12 51689097 51690019 923 + 0.242 0.154 -0.811
ENSG00000196876 E019 4.5604042 0.044401820 9.496989e-02 1.828352e-01 12 51699570 51699791 222 + 0.844 0.549 -1.237
ENSG00000196876 E020 1.9594275 0.007665898 3.048717e-01 4.469010e-01 12 51701144 51701207 64 + 0.543 0.357 -0.964
ENSG00000196876 E021 2.4734082 0.006451638 3.316408e-01 4.752834e-01 12 51702773 51702914 142 + 0.601 0.432 -0.811
ENSG00000196876 E022 5.0733277 0.003302076 2.188239e-02 5.543221e-02 12 51705417 51705623 207 + 0.888 0.551 -1.396
ENSG00000196876 E023 6.3475134 0.002814996 1.807392e-02 4.728827e-02 12 51706422 51706715 294 + 0.964 0.644 -1.270
ENSG00000196876 E024 2.7031733 0.006063836 1.971590e-01 3.226773e-01 12 51721546 51721908 363 + 0.652 0.431 -1.035
ENSG00000196876 E025 0.0000000       12 51721909 51721941 33 +      
ENSG00000196876 E026 0.6986918 0.017267182 1.199589e-01 2.199199e-01 12 51721942 51724303 2362 + 0.097 0.357 2.359
ENSG00000196876 E027 0.0000000       12 51745901 51745902 2 +      
ENSG00000196876 E028 1.9583834 0.008574374 9.538433e-02 1.834676e-01 12 51745903 51746035 133 + 0.573 0.267 -1.686
ENSG00000196876 E029 1.0726991 0.011767918 6.627287e-01 7.709717e-01 12 51751355 51751376 22 + 0.351 0.267 -0.549
ENSG00000196876 E030 4.8360115 0.061954177 4.301469e-01 5.727844e-01 12 51751377 51751593 217 + 0.812 0.683 -0.520
ENSG00000196876 E031 4.2617641 0.034880733 7.695268e-01 8.511525e-01 12 51762503 51762676 174 + 0.739 0.683 -0.230
ENSG00000196876 E032 6.5010020 0.002588989 1.909404e-01 3.149265e-01 12 51765671 51766027 357 + 0.928 0.755 -0.673
ENSG00000196876 E033 0.0000000       12 51766028 51766251 224 +      
ENSG00000196876 E034 0.0000000       12 51768113 51768172 60 +      
ENSG00000196876 E035 4.3869254 0.026026853 2.845497e-01 4.247963e-01 12 51768865 51768971 107 + 0.776 0.602 -0.729
ENSG00000196876 E036 6.9859250 0.006828387 1.387867e-01 2.464242e-01 12 51768972 51769335 364 + 0.953 0.756 -0.762
ENSG00000196876 E037 2.8721922 0.006126600 3.511966e-01 4.954069e-01 12 51769868 51769956 89 + 0.652 0.495 -0.713
ENSG00000196876 E038 1.8715242 0.011790564 3.491026e-01 4.933316e-01 12 51769957 51769985 29 + 0.397 0.550 0.772
ENSG00000196876 E039 0.0000000       12 51769986 51770009 24 +      
ENSG00000196876 E040 0.0000000       12 51770309 51770528 220 +      
ENSG00000196876 E041 3.0682901 0.212855955 5.333487e-01 6.655587e-01 12 51770529 51770683 155 + 0.541 0.685 0.633
ENSG00000196876 E042 3.4810047 0.065939666 4.207789e-01 5.639568e-01 12 51774189 51774362 174 + 0.572 0.724 0.652
ENSG00000196876 E043 0.7814233 0.109936096 4.656858e-01 6.053395e-01 12 51780202 51780271 70 + 0.300 0.154 -1.227
ENSG00000196876 E044 0.0000000       12 51780649 51780771 123 +      
ENSG00000196876 E045 5.0134364 0.003474213 5.378118e-01 6.693174e-01 12 51786542 51786764 223 + 0.811 0.721 -0.364
ENSG00000196876 E046 3.3225843 0.004780833 4.477790e-01 5.891328e-01 12 51786765 51786826 62 + 0.675 0.551 -0.548
ENSG00000196876 E047 0.1451727 0.045092870 8.137171e-01   12 51788517 51788694 178 + 0.096 0.000 -9.314
ENSG00000196876 E048 2.1057567 0.007079736 8.815369e-01 9.280964e-01 12 51788695 51788748 54 + 0.476 0.495 0.096
ENSG00000196876 E049 3.3748983 0.005137677 1.699442e-01 2.881426e-01 12 51789281 51789418 138 + 0.719 0.495 -0.993
ENSG00000196876 E050 2.7185884 0.039590386 8.887587e-02 1.733977e-01 12 51790398 51790502 105 + 0.675 0.357 -1.549
ENSG00000196876 E051 5.7868975 0.003258927 4.897725e-03 1.564535e-02 12 51794371 51794641 271 + 0.953 0.551 -1.642
ENSG00000196876 E052 94.8099809 0.000523844 5.835090e-14 1.714393e-12 12 51806282 51812864 6583 + 1.880 2.071 0.640