ENSG00000196867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301318 ENSG00000196867 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP28 protein_coding protein_coding 1.40652 1.277485 1.792914 0.241536 0.08953933 0.485775 0.63042877 0.34944857 0.8854321 0.03495018 0.05874683 1.3167986 0.44425000 0.28500000 0.4957667 0.2107667 0.06526107 0.03143662 FALSE TRUE
ENST00000589836 ENSG00000196867 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP28 protein_coding nonsense_mediated_decay 1.40652 1.277485 1.792914 0.241536 0.08953933 0.485775 0.07811177 0.00000000 0.2044034 0.00000000 0.20440344 4.4222561 0.04302917 0.00000000 0.1200667 0.1200667 0.88499836 0.03143662 TRUE FALSE
ENST00000591844 ENSG00000196867 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP28 protein_coding protein_coding 1.40652 1.277485 1.792914 0.241536 0.08953933 0.485775 0.14425746 0.05810189 0.1885560 0.02485904 0.03129259 1.5437791 0.09872083 0.05593333 0.1040333 0.0481000 0.47388812 0.03143662 FALSE TRUE
ENST00000594386 ENSG00000196867 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP28 protein_coding processed_transcript 1.40652 1.277485 1.792914 0.241536 0.08953933 0.485775 0.47772118 0.86993430 0.4740022 0.24565674 0.15886456 -0.8623821 0.36537083 0.65906667 0.2596000 -0.3994667 0.03143662 0.03143662   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196867 E001 0.1515154 0.0422296114 1.000000e+00   19 56538948 56538952 5 + 0.086 0.000 -8.802
ENSG00000196867 E002 2.9205781 0.0065429963 8.305939e-01 0.8937341678 19 56538953 56539068 116 + 0.558 0.593 0.158
ENSG00000196867 E003 3.7299872 0.0044434098 6.965465e-01 0.7968624482 19 56539069 56539129 61 + 0.630 0.689 0.251
ENSG00000196867 E004 5.9150126 0.0030251623 8.477893e-01 0.9054807334 19 56539130 56539226 97 + 0.809 0.835 0.099
ENSG00000196867 E005 10.2049529 0.0019121334 6.077680e-01 0.7276704962 19 56539625 56539716 92 + 1.042 0.989 -0.196
ENSG00000196867 E006 4.1170623 0.0355418773 6.546533e-05 0.0003581969 19 56544536 56544737 202 + 0.363 0.989 2.744
ENSG00000196867 E007 7.4371393 0.0023541044 2.085891e-02 0.0532905889 19 56547508 56547634 127 + 0.987 0.689 -1.164
ENSG00000196867 E008 6.9460865 0.0025681903 9.152188e-02 0.1775071681 19 56547807 56547902 96 + 0.947 0.730 -0.843
ENSG00000196867 E009 0.4355181 0.7567097182 6.091163e-01 0.7286577396 19 56548378 56548478 101 + 0.217 0.000 -11.553
ENSG00000196867 E010 3.8020991 0.0045579491 2.496611e-02 0.0618018059 19 56548958 56548977 20 + 0.763 0.391 -1.717
ENSG00000196867 E011 5.2467373 0.0053787820 9.315640e-01 0.9609064018 19 56548978 56549121 144 + 0.779 0.768 -0.044
ENSG00000196867 E012 4.6252484 0.0037758281 9.956287e-01 1.0000000000 19 56550067 56550181 115 + 0.729 0.730 0.006
ENSG00000196867 E013 0.1472490 0.0426906862 1.000000e+00   19 56550446 56550509 64 + 0.086 0.000 -10.885
ENSG00000196867 E014 4.1340818 0.0039349129 4.180358e-01 0.5613486227 19 56550510 56550605 96 + 0.652 0.768 0.479
ENSG00000196867 E015 3.3749103 0.0067804467 9.357850e-01 0.9636129704 19 56550606 56551029 424 + 0.630 0.643 0.056
ENSG00000196867 E016 6.2427965 0.0455764132 6.901552e-01 0.7919215310 19 56551030 56553116 2087 + 0.864 0.802 -0.244
ENSG00000196867 E017 48.1910362 0.0005434191 2.607677e-01 0.3983619890 19 56553684 56556808 3125 + 1.653 1.700 0.158