ENSG00000196839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372874 ENSG00000196839 HEK293_OSMI2_2hA HEK293_TMG_2hB ADA protein_coding protein_coding 18.84308 32.14445 12.82666 0.7776148 0.2884164 -1.324748 10.5988812 19.448888 6.4699942 0.68583230 0.3003413 -1.586365 0.55074583 0.60476667 0.50450000 -0.10026667 2.992730e-02 2.298213e-05 FALSE TRUE
ENST00000545776 ENSG00000196839 HEK293_OSMI2_2hA HEK293_TMG_2hB ADA protein_coding retained_intron 18.84308 32.14445 12.82666 0.7776148 0.2884164 -1.324748 0.6855492 0.324573 0.9856296 0.08832209 0.2062901 1.573288 0.04595000 0.01023333 0.07623333 0.06600000 2.298213e-05 2.298213e-05 FALSE TRUE
ENST00000695889 ENSG00000196839 HEK293_OSMI2_2hA HEK293_TMG_2hB ADA protein_coding protein_coding 18.84308 32.14445 12.82666 0.7776148 0.2884164 -1.324748 1.6803464 3.707248 0.9777431 0.67745280 0.4340169 -1.912027 0.08415833 0.11650000 0.07766667 -0.03883333 6.076812e-01 2.298213e-05 FALSE TRUE
ENST00000695949 ENSG00000196839 HEK293_OSMI2_2hA HEK293_TMG_2hB ADA protein_coding protein_coding 18.84308 32.14445 12.82666 0.7776148 0.2884164 -1.324748 1.3759172 3.660316 0.9135259 0.36733014 0.1707510 -1.990680 0.06336667 0.11416667 0.07156667 -0.04260000 2.710823e-01 2.298213e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196839 E001 0.8105550 0.0139148985 8.638662e-03 2.538142e-02 20 44584896 44585664 769 - 0.526 0.072 -3.711
ENSG00000196839 E002 0.1472490 0.0429435666 1.426227e-01   20 44618605 44618617 13 - 0.201 0.000 -13.693
ENSG00000196839 E003 0.1472490 0.0429435666 1.426227e-01   20 44618618 44618624 7 - 0.201 0.000 -13.693
ENSG00000196839 E004 3.7203034 0.0072750450 6.172656e-01 7.351240e-01 20 44618625 44619520 896 - 0.656 0.568 -0.388
ENSG00000196839 E005 0.2214452 0.0405512089 1.000000e+00   20 44619521 44619521 1 - 0.000 0.072 10.739
ENSG00000196839 E006 0.8877700 0.0289974328 2.154393e-01 3.449516e-01 20 44619522 44619522 1 - 0.000 0.278 13.076
ENSG00000196839 E007 1.5875059 0.0111035955 5.493829e-02 1.178897e-01 20 44619523 44619523 1 - 0.000 0.418 14.017
ENSG00000196839 E008 1.7692103 0.0081333665 3.957619e-02 9.024652e-02 20 44619524 44619524 1 - 0.000 0.447 14.184
ENSG00000196839 E009 2.1389487 0.0073166661 2.133564e-02 5.429475e-02 20 44619525 44619525 1 - 0.000 0.499 14.430
ENSG00000196839 E010 5.0820236 0.0032458590 6.335326e-01 7.482195e-01 20 44619526 44619528 3 - 0.656 0.725 0.287
ENSG00000196839 E011 15.1604709 0.0012091426 7.575012e-02 1.527053e-01 20 44619529 44619537 9 - 0.966 1.155 0.690
ENSG00000196839 E012 15.7870548 0.0011390356 4.699375e-02 1.038182e-01 20 44619538 44619539 2 - 0.966 1.177 0.765
ENSG00000196839 E013 19.0299107 0.0010136112 9.496458e-02 1.828273e-01 20 44619540 44619551 12 - 1.086 1.244 0.563
ENSG00000196839 E014 19.0299107 0.0010136112 9.496458e-02 1.828273e-01 20 44619552 44619552 1 - 1.086 1.244 0.563
ENSG00000196839 E015 19.7726097 0.0009452963 1.037616e-01 1.962377e-01 20 44619553 44619554 2 - 1.107 1.257 0.535
ENSG00000196839 E016 34.8861183 0.0006419402 2.381514e-01 3.719952e-01 20 44619555 44619559 5 - 1.401 1.479 0.270
ENSG00000196839 E017 36.3629094 0.0005965095 2.399878e-01 3.741264e-01 20 44619560 44619562 3 - 1.420 1.497 0.262
ENSG00000196839 E018 75.8885792 0.0011184086 1.028408e-01 1.948131e-01 20 44619563 44619595 33 - 1.732 1.810 0.262
ENSG00000196839 E019 75.0405501 0.0008169199 1.242417e-01 2.260412e-01 20 44619596 44619605 10 - 1.732 1.804 0.242
ENSG00000196839 E020 90.6516419 0.0029134230 1.467776e-01 2.572929e-01 20 44619606 44619655 50 - 1.814 1.884 0.235
ENSG00000196839 E021 211.6406816 0.0002331492 1.559197e-03 5.826827e-03 20 44619656 44619809 154 - 2.162 2.250 0.293
ENSG00000196839 E022 149.3416920 0.0002442141 1.104642e-04 5.700811e-04 20 44619810 44619836 27 - 1.971 2.105 0.451
ENSG00000196839 E023 114.7140769 0.0003208251 1.128227e-05 7.405813e-05 20 44619837 44619842 6 - 1.818 1.999 0.610
ENSG00000196839 E024 108.0841175 0.0003109586 2.485459e-04 1.169119e-03 20 44619843 44619847 5 - 1.818 1.970 0.512
ENSG00000196839 E025 4.2224549 0.0054653157 6.258163e-01 7.418703e-01 20 44619848 44619860 13 - 0.709 0.627 -0.350
ENSG00000196839 E026 5.7628357 0.0240186379 2.067223e-01 3.346344e-01 20 44619861 44619945 85 - 0.906 0.709 -0.778
ENSG00000196839 E027 9.2520559 0.0395655515 1.871779e-01 3.101926e-01 20 44619946 44620298 353 - 1.085 0.881 -0.758
ENSG00000196839 E028 203.5544383 0.0002027597 1.039068e-06 8.590741e-06 20 44620299 44620401 103 - 2.094 2.240 0.489
ENSG00000196839 E029 1.4381686 0.0099229522 4.303519e-01 5.730010e-01 20 44620402 44621017 616 - 0.201 0.354 1.096
ENSG00000196839 E030 228.3731412 0.0001830955 1.375756e-01 2.447095e-01 20 44621018 44621147 130 - 2.237 2.271 0.115
ENSG00000196839 E031 1.3253775 0.0099363630 3.882806e-01 5.323852e-01 20 44621148 44622587 1440 - 0.442 0.278 -0.975
ENSG00000196839 E032 142.6810925 0.0004427598 7.202922e-01 8.149277e-01 20 44622588 44622652 65 - 2.055 2.060 0.018
ENSG00000196839 E033 1.3338852 0.0104110120 2.126042e-02 5.413658e-02 20 44622653 44622828 176 - 0.596 0.187 -2.448
ENSG00000196839 E034 190.6480215 0.0002033313 8.414818e-01 9.011249e-01 20 44622829 44622930 102 - 2.198 2.184 -0.045
ENSG00000196839 E035 5.8133760 0.0073503900 6.071794e-03 1.880008e-02 20 44622931 44623006 76 - 1.018 0.645 -1.463
ENSG00000196839 E036 66.0830183 0.0004091216 1.950108e-01 3.199934e-01 20 44623007 44623033 27 - 1.790 1.718 -0.244
ENSG00000196839 E037 79.2380017 0.0007069271 9.702132e-02 1.859216e-01 20 44623034 44623075 42 - 1.876 1.792 -0.284
ENSG00000196839 E038 53.7419828 0.0103197080 7.607354e-02 1.532268e-01 20 44623076 44623078 3 - 1.751 1.613 -0.465
ENSG00000196839 E039 3.4873303 0.1331125467 8.388237e-01 8.992595e-01 20 44623079 44623147 69 - 0.596 0.558 -0.171
ENSG00000196839 E040 8.8517633 0.0031715149 4.243936e-02 9.551655e-02 20 44623148 44623751 604 - 1.086 0.841 -0.915
ENSG00000196839 E041 2.5592285 0.3224265877 3.067386e-01 4.489214e-01 20 44623752 44623971 220 - 0.658 0.405 -1.204
ENSG00000196839 E042 3.9879510 0.0041956323 3.553358e-04 1.600735e-03 20 44623972 44624201 230 - 0.966 0.447 -2.196
ENSG00000196839 E043 149.6029945 0.0002575435 1.701391e-01 2.883680e-01 20 44624202 44624329 128 - 2.124 2.070 -0.179
ENSG00000196839 E044 7.5671894 0.0022913792 2.090910e-04 1.002852e-03 20 44624330 44624647 318 - 1.163 0.725 -1.652
ENSG00000196839 E045 1.8372593 0.0112211575 8.138813e-07 6.890132e-06 20 44624648 44624725 78 - 0.874 0.072 -5.170
ENSG00000196839 E046 9.6750848 0.0046889345 5.192355e-07 4.577579e-06 20 44624726 44625568 843 - 1.310 0.767 -2.002
ENSG00000196839 E047 126.9105514 0.0003103263 8.247037e-01 8.895638e-01 20 44625569 44625684 116 - 2.022 2.007 -0.053
ENSG00000196839 E048 3.2148701 0.0047863718 4.378831e-01 5.797607e-01 20 44625685 44625962 278 - 0.657 0.523 -0.597
ENSG00000196839 E049 3.7341413 0.0043231971 1.525825e-06 1.218082e-05 20 44626323 44626455 133 - 1.042 0.354 -2.993
ENSG00000196839 E050 159.9313257 0.0002806516 1.206335e-01 2.208638e-01 20 44626456 44626599 144 - 2.155 2.097 -0.194
ENSG00000196839 E051 9.9525143 0.0241394879 1.236297e-04 6.304684e-04 20 44626600 44627546 947 - 1.285 0.796 -1.799
ENSG00000196839 E052 9.1273440 0.0023467686 1.975622e-10 3.312174e-09 20 44627547 44629046 1500 - 1.358 0.679 -2.530
ENSG00000196839 E053 77.2327071 0.0003786882 1.182164e-01 2.173732e-01 20 44629047 44629048 2 - 1.859 1.779 -0.269
ENSG00000196839 E054 149.0821170 0.0017576696 6.607177e-03 2.020484e-02 20 44629049 44629166 118 - 2.164 2.055 -0.366
ENSG00000196839 E055 56.9373476 0.0072305804 6.090582e-02 1.281592e-01 20 44629167 44629169 3 - 1.769 1.639 -0.440
ENSG00000196839 E056 0.3686942 0.0309535951 3.961792e-01 5.399698e-01 20 44635990 44636070 81 - 0.201 0.072 -1.709
ENSG00000196839 E057 0.1472490 0.0429435666 1.426227e-01   20 44636071 44636106 36 - 0.201 0.000 -13.693
ENSG00000196839 E058 0.4031496 0.0255130769 7.763372e-01 8.559745e-01 20 44636107 44636226 120 - 0.000 0.134 11.829
ENSG00000196839 E059 92.3513059 0.0058790380 2.911236e-03 1.000323e-02 20 44636227 44636288 62 - 2.002 1.835 -0.564
ENSG00000196839 E060 0.1817044 0.0407875750 1.000000e+00   20 44647327 44647358 32 - 0.000 0.072 10.735
ENSG00000196839 E061 0.4031496 0.0255130769 7.763372e-01 8.559745e-01 20 44647359 44647433 75 - 0.000 0.134 11.829
ENSG00000196839 E062 0.1482932 0.0415733164 1.000000e+00   20 44651118 44651574 457 - 0.000 0.072 10.727
ENSG00000196839 E063 69.3791866 0.0074758937 2.070346e-03 7.442520e-03 20 44651575 44651745 171 - 1.900 1.703 -0.663
ENSG00000196839 E064 0.9599055 0.0301308923 1.727391e-01 2.917646e-01 20 44651902 44652099 198 - 0.442 0.187 -1.714
ENSG00000196839 E065 0.1515154 0.0447039184 1.422891e-01   20 44652100 44652252 153 - 0.201 0.000 -13.677