ENSG00000196814

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000361171	ENSG00000196814	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MVB12B	protein_coding	protein_coding	6.936343	10.81595	6.259408	0.516358	0.2758305	-0.7880918	4.816163	4.523184	5.756366	0.9220026	0.2133962	0.3471377	0.7203208	0.4117333	0.9213333	0.5096000	1.833952e-06	1.017432e-20	FALSE	TRUE
MSTRG.33395.3	ENSG00000196814	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MVB12B	protein_coding		6.936343	10.81595	6.259408	0.516358	0.2758305	-0.7880918	1.719580	5.523216	0.000000	0.4155878	0.0000000	-9.1119745	0.2210125	0.5166333	0.0000000	-0.5166333	1.017432e-20	1.017432e-20	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
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width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000196814	E001	2.8378386	0.0054414757	2.175098e-06	1.677997e-05	9	126326829	126326861	33	+	0.872	0.193	-3.526
ENSG00000196814	E002	9.6175736	0.0019044164	4.984754e-03	1.588766e-02	9	126326862	126326940	79	+	1.118	0.918	-0.737
ENSG00000196814	E003	16.8518208	0.0012588573	4.872014e-05	2.753053e-04	9	126326941	126327010	70	+	1.361	1.124	-0.836
ENSG00000196814	E004	0.2955422	0.0298706774	6.909843e-01		9	126327011	126327015	5	+	0.140	0.107	-0.441
ENSG00000196814	E005	0.0000000				9	126335219	126335407	189	+
ENSG00000196814	E006	43.6645977	0.0005353456	5.798404e-07	5.068240e-06	9	126340508	126340630	123	+	1.727	1.566	-0.547
ENSG00000196814	E007	57.1132004	0.0004538459	1.885988e-05	1.176744e-04	9	126381064	126381171	108	+	1.808	1.713	-0.322
ENSG00000196814	E008	65.4908314	0.0104157175	6.266132e-04	2.630634e-03	9	126386562	126386658	97	+	1.878	1.764	-0.387
ENSG00000196814	E009	73.1345552	0.0014884039	6.379383e-04	2.672848e-03	9	126392066	126392195	130	+	1.883	1.836	-0.160
ENSG00000196814	E010	51.0030747	0.0008111958	1.574369e-02	4.215801e-02	9	126395575	126395639	65	+	1.711	1.691	-0.066
ENSG00000196814	E011	43.4984726	0.0005383782	1.374332e-02	3.763777e-02	9	126395640	126395697	58	+	1.649	1.619	-0.103
ENSG00000196814	E012	8.9653093	0.0236232168	1.675587e-01	2.850127e-01	9	126395698	126397633	1936	+	0.800	1.082	1.062
ENSG00000196814	E013	51.8487423	0.0006051519	1.292295e-02	3.573253e-02	9	126421854	126421948	95	+	1.723	1.703	-0.069
ENSG00000196814	E014	1.6522545	0.0081333665	8.331592e-01	8.954708e-01	9	126448026	126448141	116	+	0.401	0.428	0.146
ENSG00000196814	E015	2.7959251	0.0056841074	1.202737e-01	2.203751e-01	9	126448142	126448409	268	+	0.330	0.666	1.677
ENSG00000196814	E016	0.5483223	0.0204239796	9.170759e-01	9.516047e-01	9	126480813	126481368	556	+	0.139	0.193	0.564
ENSG00000196814	E017	36.4792062	0.0006173477	2.287946e-02	5.749213e-02	9	126481369	126481424	56	+	1.577	1.546	-0.107
ENSG00000196814	E018	38.4344334	0.0046381056	1.683459e-01	2.860438e-01	9	126483973	126484032	60	+	1.568	1.581	0.044
ENSG00000196814	E019	900.0827935	0.0062103193	5.656937e-10	8.780744e-09	9	126503177	126507041	3865	+	2.796	3.011	0.713

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000196814

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3