ENSG00000196739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356083 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding protein_coding 3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.2974235 0.1003215 0.49244129 0.07565599 0.04641933 2.18724048 0.08903333 0.02023333 0.1277333 0.10750000 0.009079303 0.008336925 FALSE TRUE
ENST00000468565 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding processed_transcript 3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.4245138 1.0522057 0.09346358 0.25203409 0.07574328 -3.35986831 0.10554167 0.23573333 0.0226000 -0.21313333 0.008336925 0.008336925 FALSE TRUE
ENST00000485397 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding retained_intron 3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.4545330 0.2287086 0.55318060 0.05534144 0.10501923 1.23834687 0.12879167 0.04990000 0.1412000 0.09130000 0.014925314 0.008336925   FALSE
ENST00000490831 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding processed_transcript 3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.2553639 0.3059184 0.44911742 0.09470383 0.14681031 0.53931132 0.06377083 0.07286667 0.1128333 0.03996667 0.696405322 0.008336925 FALSE FALSE
ENST00000494090 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding nonsense_mediated_decay 3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.6214659 0.8427362 0.62741430 0.18341377 0.14125098 -0.41986821 0.16317917 0.18540000 0.1602667 -0.02513333 0.858906949 0.008336925 FALSE TRUE
MSTRG.33270.4 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding   3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.4527246 0.3266094 0.26434707 0.32660940 0.26434707 -0.29507329 0.12312083 0.08526667 0.0677000 -0.01756667 1.000000000 0.008336925 FALSE TRUE
MSTRG.33270.5 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding   3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.1833388 0.4060635 0.32736290 0.27426725 0.30594590 -0.30250240 0.05057083 0.08113333 0.0961000 0.01496667 0.876066226 0.008336925 FALSE TRUE
MSTRG.33270.6 ENSG00000196739 HEK293_OSMI2_2hA HEK293_TMG_2hB COL27A1 protein_coding   3.680457 4.46403 3.851468 0.4310682 0.2611638 -0.2124256 0.7662766 0.9501546 0.91060757 0.13178532 0.05511239 -0.06068043 0.20980000 0.21933333 0.2368667 0.01753333 0.899934284 0.008336925 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196739 E001 3.4450411 0.0223255219 0.0656849443 0.136189230 9 114155537 114155770 234 + 0.770 0.496 -1.196
ENSG00000196739 E002 1.2867575 0.0100493341 0.0920569355 0.178322815 9 114155771 114155997 227 + 0.490 0.206 -1.785
ENSG00000196739 E003 0.4741261 0.0221343475 0.4653613541 0.605079631 9 114155998 114156012 15 + 0.230 0.115 -1.201
ENSG00000196739 E004 0.6192988 0.0193689005 0.2354152792 0.368855757 9 114162715 114162717 3 + 0.311 0.115 -1.786
ENSG00000196739 E005 0.9482522 0.1180674434 0.3523157285 0.496586199 9 114162718 114162728 11 + 0.379 0.206 -1.195
ENSG00000196739 E006 1.4641954 0.1258381632 0.2951067770 0.436225479 9 114162729 114162735 7 + 0.490 0.283 -1.183
ENSG00000196739 E007 4.8212300 0.0035842467 0.7941921869 0.868485069 9 114162736 114162785 50 + 0.715 0.768 0.215
ENSG00000196739 E008 6.0724098 0.0775285210 0.6597608207 0.768519514 9 114167689 114167714 26 + 0.770 0.876 0.416
ENSG00000196739 E009 46.2619659 0.0104059180 0.1004949899 0.191203093 9 114167715 114168607 893 + 1.712 1.623 -0.304
ENSG00000196739 E010 29.1593330 0.0067718707 0.0155591875 0.041754843 9 114168608 114168960 353 + 1.546 1.391 -0.535
ENSG00000196739 E011 12.3974457 0.0061465334 0.0185698130 0.048383873 9 114168961 114169051 91 + 1.232 1.018 -0.769
ENSG00000196739 E012 37.9629361 0.0005816607 0.3446183156 0.488703710 9 114169052 114169463 412 + 1.599 1.566 -0.113
ENSG00000196739 E013 11.2708829 0.0069840203 0.8906550215 0.934176656 9 114178291 114178344 54 + 1.073 1.078 0.019
ENSG00000196739 E014 12.6902752 0.0015178178 0.6473126231 0.758999751 9 114183022 114183075 54 + 1.085 1.148 0.226
ENSG00000196739 E015 11.8887069 0.0017131880 0.6997377962 0.799368205 9 114194404 114194457 54 + 1.073 1.128 0.202
ENSG00000196739 E016 15.5154127 0.0011914224 0.5593065012 0.687433509 9 114195959 114196012 54 + 1.223 1.192 -0.107
ENSG00000196739 E017 15.8444824 0.0011111316 0.1904460550 0.314316375 9 114205102 114205146 45 + 1.266 1.175 -0.321
ENSG00000196739 E018 15.0189948 0.0142401303 0.1079363662 0.202471664 9 114205759 114205812 54 + 1.282 1.137 -0.514
ENSG00000196739 E019 12.0091092 0.0082585505 0.0350671008 0.081777479 9 114206252 114206296 45 + 1.214 1.017 -0.707
ENSG00000196739 E020 12.9452305 0.0071787340 0.0045877105 0.014785614 9 114209675 114209728 54 + 1.266 1.005 -0.935
ENSG00000196739 E021 14.0202058 0.0013337124 0.0027718500 0.009588757 9 114210982 114211018 37 + 1.290 1.042 -0.884
ENSG00000196739 E022 6.3675963 0.0053291318 0.0022390528 0.007963613 9 114211019 114211026 8 + 1.032 0.667 -1.423
ENSG00000196739 E023 2.6425394 0.1372941142 0.3115050768 0.453958086 9 114217770 114218579 810 + 0.652 0.456 -0.906
ENSG00000196739 E024 12.9990781 0.0020390599 0.0007585507 0.003110030 9 114219791 114219844 54 + 1.274 0.978 -1.064
ENSG00000196739 E025 11.1853598 0.0015609249 0.5235571117 0.657220831 9 114222223 114222267 45 + 1.097 1.054 -0.158
ENSG00000196739 E026 15.7415473 0.0011879999 0.0064652958 0.019832403 9 114231079 114231132 54 + 1.320 1.109 -0.748
ENSG00000196739 E027 14.2853540 0.0304747352 0.0342951913 0.080321442 9 114231822 114231858 37 + 1.289 1.060 -0.817
ENSG00000196739 E028 6.7681774 0.1095613776 0.1409233460 0.249292719 9 114231859 114231866 8 + 1.031 0.743 -1.104
ENSG00000196739 E029 13.5552241 0.0133199276 0.0384411060 0.088176099 9 114235599 114235652 54 + 1.249 1.057 -0.687
ENSG00000196739 E030 11.6133419 0.0247419189 0.0815007174 0.161899866 9 114236981 114237034 54 + 1.184 0.997 -0.678
ENSG00000196739 E031 12.1953248 0.0017501932 0.2126720192 0.341699044 9 114237662 114237715 54 + 1.154 1.054 -0.360
ENSG00000196739 E032 10.7929065 0.0057426859 0.3365726085 0.480430010 9 114240220 114240273 54 + 1.098 1.019 -0.287
ENSG00000196739 E033 0.3729606 0.0272175579 0.8901191366 0.933795533 9 114240274 114240433 160 + 0.130 0.115 -0.199
ENSG00000196739 E034 11.5670436 0.0110470680 0.1380780956 0.245402299 9 114240434 114240487 54 + 1.154 1.020 -0.486
ENSG00000196739 E035 12.3574587 0.0020683953 0.9309706188 0.960550674 9 114242187 114242231 45 + 1.097 1.109 0.042
ENSG00000196739 E036 9.9195421 0.0018064375 0.8530334837 0.908963577 9 114243507 114243560 54 + 1.018 1.018 0.000
ENSG00000196739 E037 8.6465023 0.0126155142 0.8733634725 0.922624461 9 114245866 114245910 45 + 0.939 0.980 0.156
ENSG00000196739 E038 3.6161363 0.0043404167 0.0890332717 0.173652966 9 114245911 114246121 211 + 0.770 0.535 -1.008
ENSG00000196739 E039 10.8167884 0.0018220968 0.5234260351 0.657129456 9 114250615 114250668 54 + 1.003 1.088 0.309
ENSG00000196739 E040 13.1162138 0.0013368593 0.5097511225 0.645031032 9 114252593 114252646 54 + 1.085 1.166 0.292
ENSG00000196739 E041 0.5483223 0.0197078830 0.6794716620 0.783631668 9 114252647 114252653 7 + 0.130 0.206 0.801
ENSG00000196739 E042 15.1683785 0.0013593089 0.0246476029 0.061155612 9 114252879 114252932 54 + 1.046 1.270 0.800
ENSG00000196739 E043 16.3100770 0.0011252376 0.0750082313 0.151543521 9 114258541 114258594 54 + 1.109 1.284 0.620
ENSG00000196739 E044 15.9872811 0.0015895843 0.2504496956 0.386479620 9 114264355 114264408 54 + 1.143 1.263 0.423
ENSG00000196739 E045 13.0797813 0.0014174066 0.4310313230 0.573623439 9 114264924 114264968 45 + 1.073 1.166 0.338
ENSG00000196739 E046 11.2602039 0.0214108866 0.4057491174 0.549398219 9 114265066 114265110 45 + 0.988 1.116 0.467
ENSG00000196739 E047 14.2265118 0.0226808787 0.6970218970 0.797260773 9 114265422 114265475 54 + 1.121 1.192 0.255
ENSG00000196739 E048 15.2615465 0.0086687346 0.9412975112 0.967107883 9 114266565 114266618 54 + 1.175 1.204 0.104
ENSG00000196739 E049 17.8884290 0.0010832966 0.9066903431 0.944739851 9 114267504 114267557 54 + 1.241 1.270 0.104
ENSG00000196739 E050 5.6518207 0.0051013621 0.2275634790 0.359481834 9 114268807 114269240 434 + 0.883 0.745 -0.541
ENSG00000196739 E051 12.9994062 0.0396707959 0.7046928167 0.803183448 9 114269241 114269294 54 + 1.132 1.122 -0.036
ENSG00000196739 E052 21.2453415 0.0189143805 0.5519815930 0.681365433 9 114270728 114270781 54 + 1.348 1.318 -0.104
ENSG00000196739 E053 0.4804688 0.0222807967 0.4643632418 0.604100332 9 114270782 114274230 3449 + 0.230 0.115 -1.201
ENSG00000196739 E054 27.5507128 0.0011971449 0.5277380340 0.660760749 9 114275661 114275768 108 + 1.451 1.429 -0.075
ENSG00000196739 E055 21.0986727 0.0064863294 0.9151984975 0.950317408 9 114282277 114282330 54 + 1.320 1.348 0.098
ENSG00000196739 E056 26.1334191 0.0007757636 0.3603574978 0.504673119 9 114282457 114282564 108 + 1.374 1.457 0.284
ENSG00000196739 E057 19.5817787 0.0011106232 0.4626815945 0.602541201 9 114283709 114283762 54 + 1.327 1.290 -0.128
ENSG00000196739 E058 19.6310024 0.0068009406 0.0581807803 0.123512310 9 114284724 114284777 54 + 1.387 1.247 -0.488
ENSG00000196739 E059 21.5823281 0.0075760717 0.7022264972 0.801085353 9 114288455 114288511 57 + 1.348 1.337 -0.039
ENSG00000196739 E060 20.7916264 0.0145621882 0.9095944237 0.946547374 9 114288702 114288755 54 + 1.298 1.336 0.133
ENSG00000196739 E061 17.8199473 0.0011151981 0.6149384267 0.733334425 9 114288914 114288967 54 + 1.223 1.284 0.215
ENSG00000196739 E062 17.0697345 0.0010587900 0.8769512126 0.925003568 9 114289242 114289295 54 + 1.223 1.255 0.115
ENSG00000196739 E063 16.0970654 0.0011433940 0.1727715803 0.291801278 9 114290058 114290111 54 + 1.132 1.270 0.488
ENSG00000196739 E064 23.2578867 0.0014022576 0.9313622551 0.960755918 9 114290224 114290331 108 + 1.368 1.382 0.047
ENSG00000196739 E065 31.6865417 0.0010774212 0.7575222143 0.842331609 9 114290810 114290917 108 + 1.482 1.521 0.135
ENSG00000196739 E066 34.8018025 0.0007252848 0.3423120282 0.486313901 9 114292103 114292210 108 + 1.496 1.573 0.263
ENSG00000196739 E067 23.2314679 0.0008303914 0.4959104540 0.632651500 9 114300070 114300123 54 + 1.334 1.403 0.238
ENSG00000196739 E068 0.4470576 0.0230002971 0.4637378017 0.603509196 9 114300362 114300624 263 + 0.230 0.115 -1.204
ENSG00000196739 E069 21.2190192 0.0009523198 0.0278599496 0.067739410 9 114300625 114300687 63 + 1.214 1.403 0.662
ENSG00000196739 E070 19.7688178 0.0114129171 0.0942888526 0.181818314 9 114301072 114301125 54 + 1.185 1.369 0.645
ENSG00000196739 E071 14.4093978 0.0136281766 0.2600883507 0.397564551 9 114301284 114301319 36 + 1.085 1.228 0.510
ENSG00000196739 E072 8.9521745 0.0039966723 0.7828706211 0.860585767 9 114301445 114301462 18 + 0.955 1.005 0.184
ENSG00000196739 E073 0.3268771 0.0289336871 0.8936257813   9 114301463 114301542 80 + 0.130 0.115 -0.201
ENSG00000196739 E074 11.5474553 0.0030327000 0.5685293954 0.695191808 9 114301682 114301717 36 + 1.032 1.109 0.280
ENSG00000196739 E075 10.9219156 0.0157358460 0.7255014275 0.818747268 9 114302082 114302108 27 + 1.018 1.081 0.232
ENSG00000196739 E076 18.6955634 0.0010004504 0.5467962015 0.676896788 9 114304608 114304673 66 + 1.298 1.270 -0.097
ENSG00000196739 E077 2.7678150 0.0057357159 0.8882882014 0.932582253 9 114306213 114306519 307 + 0.579 0.572 -0.032
ENSG00000196739 E078 36.8999135 0.0006726689 0.7526445827 0.838767680 9 114306520 114306688 169 + 1.568 1.570 0.007
ENSG00000196739 E079 4.1600254 0.0537094172 0.1727846946 0.291820826 9 114307032 114307668 637 + 0.537 0.792 1.087
ENSG00000196739 E080 34.6259648 0.0066442315 0.1608522760 0.276228384 9 114307669 114307778 110 + 1.472 1.591 0.408
ENSG00000196739 E081 48.9737139 0.0085885607 0.9466006820 0.970492770 9 114309260 114309478 219 + 1.679 1.697 0.060
ENSG00000196739 E082 206.9057106 0.0163923935 0.0005170422 0.002223455 9 114310549 114312511 1963 + 2.154 2.397 0.809