ENSG00000196730

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-4 / 4
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000358077	ENSG00000196730	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DAPK1	protein_coding	protein_coding	9.478773	6.756603	10.67551	0.5036006	0.1805408	0.6591524	0.3451939	1.86470663	0.0000000	1.19591255	0.00000000	-7.5505210	0.04354167	0.25373333	0.00000000	-0.25373333	1.190609e-01	5.124439e-08	FALSE
ENST00000408954	ENSG00000196730	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DAPK1	protein_coding	protein_coding	9.478773	6.756603	10.67551	0.5036006	0.1805408	0.6591524	5.5098855	3.71038051	6.8143729	0.43943280	0.50971147	0.8752463	0.58999167	0.56016667	0.63706667	0.07690000	7.510275e-01	5.124439e-08	FALSE
ENST00000463069	ENSG00000196730	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DAPK1	protein_coding	retained_intron	9.478773	6.756603	10.67551	0.5036006	0.1805408	0.6591524	1.0495438	0.05013527	0.9919189	0.05013527	0.05214414	4.0584105	0.09699167	0.00670000	0.09286667	0.08616667	7.881489e-07	5.124439e-08
ENST00000472284	ENSG00000196730	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DAPK1	protein_coding	protein_coding	9.478773	6.756603	10.67551	0.5036006	0.1805408	0.6591524	1.2629116	0.49612606	0.5678197	0.49612606	0.33677586	0.1911227	0.13228333	0.08563333	0.05426667	-0.03136667	7.190992e-01	5.124439e-08	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 51
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000196730	E001	0.0000000				9	87497228	87497302	75	+
ENSG00000196730	E002	0.6362506	0.4390275466	6.789563e-01	7.832831e-01	9	87497681	87497735	55	+	0.264	0.141	-1.123
ENSG00000196730	E003	1.9261286	0.0082213962	4.853394e-01	6.232155e-01	9	87497736	87497772	37	+	0.507	0.403	-0.534
ENSG00000196730	E004	1.9208300	0.0074015699	9.059939e-01	9.442375e-01	9	87497773	87497834	62	+	0.468	0.464	-0.020
ENSG00000196730	E005	3.7622525	0.0042286328	6.877171e-01	7.899996e-01	9	87497835	87497866	32	+	0.688	0.648	-0.171
ENSG00000196730	E006	13.8120505	0.0112817865	5.430120e-01	6.736913e-01	9	87497867	87497911	45	+	1.187	1.147	-0.145
ENSG00000196730	E007	35.5331656	0.0210939088	2.414168e-02	6.010406e-02	9	87497912	87498107	196	+	1.639	1.447	-0.658
ENSG00000196730	E008	0.9058703	0.6823919945	6.076913e-01	7.276004e-01	9	87498535	87498610	76	+	0.381	0.137	-1.922
ENSG00000196730	E009	0.4545463	0.6221035123	3.648809e-01	5.092162e-01	9	87498611	87498636	26	+	0.264	0.000	-10.978
ENSG00000196730	E010	28.1989127	0.0133591475	2.795816e-03	9.661785e-03	9	87498970	87499004	35	+	1.558	1.314	-0.842
ENSG00000196730	E011	19.8468874	0.0131159967	4.385284e-04	1.922743e-03	9	87499005	87499005	1	+	1.436	1.111	-1.141
ENSG00000196730	E012	51.3632513	0.0062352556	8.688426e-04	3.505028e-03	9	87499006	87499139	134	+	1.794	1.607	-0.632
ENSG00000196730	E013	0.4375944	0.0274195748	1.361678e-01	2.427159e-01	9	87499140	87499352	213	+	0.263	0.000	-12.479
ENSG00000196730	E014	1.5477676	0.0098182198	3.035349e-01	4.454583e-01	9	87506820	87507002	183	+	0.324	0.517	1.048
ENSG00000196730	E015	58.1591616	0.0008863195	3.402900e-04	1.541538e-03	9	87604954	87605175	222	+	1.831	1.682	-0.504
ENSG00000196730	E016	51.9854173	0.0004764891	3.910440e-04	1.740202e-03	9	87637943	87638081	139	+	1.786	1.634	-0.514
ENSG00000196730	E017	46.6174183	0.0044574216	1.338307e-03	5.104249e-03	9	87639354	87639437	84	+	1.747	1.573	-0.590
ENSG00000196730	E018	39.1531593	0.0029705739	1.232626e-01	2.246324e-01	9	87639438	87639483	46	+	1.632	1.559	-0.247
ENSG00000196730	E019	38.6117116	0.0263346106	3.569164e-01	5.013215e-01	9	87639650	87639698	49	+	1.630	1.552	-0.267
ENSG00000196730	E020	4.4317784	0.0039597536	1.124016e-02	3.173875e-02	9	87639699	87639788	90	+	0.867	0.518	-1.473
ENSG00000196730	E021	37.1238887	0.0018532180	4.842693e-03	1.549326e-02	9	87639789	87639815	27	+	1.645	1.499	-0.500
ENSG00000196730	E022	64.8346474	0.0003727506	1.300562e-04	6.590897e-04	9	87640298	87640450	153	+	1.881	1.737	-0.487
ENSG00000196730	E023	42.5830813	0.0016431507	7.806130e-04	3.189667e-03	9	87640802	87640847	46	+	1.711	1.544	-0.567
ENSG00000196730	E024	54.3243660	0.0004137297	3.718411e-04	1.665426e-03	9	87641969	87642058	90	+	1.807	1.660	-0.497
ENSG00000196730	E025	46.7775620	0.0010581509	5.213570e-02	1.129608e-01	9	87643376	87643468	93	+	1.713	1.634	-0.268
ENSG00000196730	E026	55.6235347	0.0004502041	1.622357e-02	4.321822e-02	9	87645895	87646014	120	+	1.792	1.702	-0.304
ENSG00000196730	E027	47.7319800	0.0023032718	1.625156e-01	2.784212e-01	9	87646461	87646559	99	+	1.713	1.660	-0.181
ENSG00000196730	E028	44.2309930	0.0064641061	9.084733e-01	9.458648e-01	9	87647305	87647403	99	+	1.648	1.661	0.042
ENSG00000196730	E029	0.2214452	0.0403991316	3.751443e-01		9	87648575	87648585	11	+	0.000	0.141	10.638
ENSG00000196730	E030	0.5503986	0.0215669348	4.210487e-01	5.641995e-01	9	87648586	87648780	195	+	0.106	0.247	1.469
ENSG00000196730	E031	46.1632460	0.0004999222	8.151541e-02	1.619219e-01	9	87648781	87648879	99	+	1.704	1.638	-0.224
ENSG00000196730	E032	42.3671997	0.0005524085	5.430986e-01	6.737503e-01	9	87649921	87649989	69	+	1.643	1.634	-0.029
ENSG00000196730	E033	64.8776749	0.0025603656	1.256663e-01	2.280955e-01	9	87649990	87650118	129	+	1.845	1.795	-0.168
ENSG00000196730	E034	2.0564378	0.0073663072	8.446553e-01	9.033285e-01	9	87650119	87650511	393	+	0.468	0.518	0.243
ENSG00000196730	E035	78.8029922	0.0003854565	2.479124e-01	3.834732e-01	9	87651527	87651724	198	+	1.915	1.893	-0.071
ENSG00000196730	E036	0.2214452	0.0403991316	3.751443e-01		9	87657416	87658028	613	+	0.000	0.141	10.638
ENSG00000196730	E037	53.0470427	0.0005206739	5.089147e-01	6.442954e-01	9	87658029	87658127	99	+	1.738	1.730	-0.026
ENSG00000196730	E038	0.2966881	0.0290785164	2.871238e-01		9	87667778	87668047	270	+	0.191	0.000	-11.900
ENSG00000196730	E039	0.0000000				9	87668453	87668596	144	+
ENSG00000196730	E040	41.9452728	0.0005293145	6.107012e-01	7.299890e-01	9	87668597	87668674	78	+	1.637	1.634	-0.011
ENSG00000196730	E041	0.0000000				9	87668675	87668948	274	+
ENSG00000196730	E042	72.6136968	0.0004015500	4.494235e-01	5.906277e-01	9	87681404	87681626	223	+	1.870	1.863	-0.024
ENSG00000196730	E043	71.4394679	0.0008008350	4.625782e-01	6.024408e-01	9	87686551	87686739	189	+	1.863	1.856	-0.025
ENSG00000196730	E044	76.8497070	0.0003527529	4.072006e-01	5.507967e-01	9	87697007	87697204	198	+	1.865	1.922	0.192
ENSG00000196730	E045	1.5749379	0.0235232302	8.351520e-01	8.968356e-01	9	87698409	87698655	247	+	0.425	0.403	-0.119
ENSG00000196730	E046	71.1013416	0.0004081187	9.435166e-01	9.685555e-01	9	87698656	87698794	139	+	1.845	1.872	0.091
ENSG00000196730	E047	58.6959925	0.0006891645	8.526476e-01	9.086883e-01	9	87700117	87700237	121	+	1.768	1.783	0.051
ENSG00000196730	E048	64.1248963	0.0004357511	9.947429e-01	1.000000e+00	9	87703029	87703217	189	+	1.803	1.827	0.080
ENSG00000196730	E049	260.5701849	0.0037277587	6.322319e-03	1.946318e-02	9	87706132	87707360	1229	+	2.360	2.479	0.396
ENSG00000196730	E050	132.6378751	0.0005105335	3.091089e-17	1.416540e-15	9	87707361	87707836	476	+	1.968	2.259	0.972
ENSG00000196730	E051	242.7285714	0.0050034486	8.804734e-18	4.360864e-16	9	87707837	87708678	842	+	2.186	2.543	1.191

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000196730

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3