ENSG00000196730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358077 ENSG00000196730 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK1 protein_coding protein_coding 9.478773 6.756603 10.67551 0.5036006 0.1805408 0.6591524 0.3451939 1.86470663 0.0000000 1.19591255 0.00000000 -7.5505210 0.04354167 0.25373333 0.00000000 -0.25373333 1.190609e-01 5.124439e-08 FALSE  
ENST00000408954 ENSG00000196730 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK1 protein_coding protein_coding 9.478773 6.756603 10.67551 0.5036006 0.1805408 0.6591524 5.5098855 3.71038051 6.8143729 0.43943280 0.50971147 0.8752463 0.58999167 0.56016667 0.63706667 0.07690000 7.510275e-01 5.124439e-08 FALSE  
ENST00000463069 ENSG00000196730 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK1 protein_coding retained_intron 9.478773 6.756603 10.67551 0.5036006 0.1805408 0.6591524 1.0495438 0.05013527 0.9919189 0.05013527 0.05214414 4.0584105 0.09699167 0.00670000 0.09286667 0.08616667 7.881489e-07 5.124439e-08    
ENST00000472284 ENSG00000196730 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK1 protein_coding protein_coding 9.478773 6.756603 10.67551 0.5036006 0.1805408 0.6591524 1.2629116 0.49612606 0.5678197 0.49612606 0.33677586 0.1911227 0.13228333 0.08563333 0.05426667 -0.03136667 7.190992e-01 5.124439e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196730 E001 0.0000000       9 87497228 87497302 75 +      
ENSG00000196730 E002 0.6362506 0.4390275466 6.789563e-01 7.832831e-01 9 87497681 87497735 55 + 0.264 0.141 -1.123
ENSG00000196730 E003 1.9261286 0.0082213962 4.853394e-01 6.232155e-01 9 87497736 87497772 37 + 0.507 0.403 -0.534
ENSG00000196730 E004 1.9208300 0.0074015699 9.059939e-01 9.442375e-01 9 87497773 87497834 62 + 0.468 0.464 -0.020
ENSG00000196730 E005 3.7622525 0.0042286328 6.877171e-01 7.899996e-01 9 87497835 87497866 32 + 0.688 0.648 -0.171
ENSG00000196730 E006 13.8120505 0.0112817865 5.430120e-01 6.736913e-01 9 87497867 87497911 45 + 1.187 1.147 -0.145
ENSG00000196730 E007 35.5331656 0.0210939088 2.414168e-02 6.010406e-02 9 87497912 87498107 196 + 1.639 1.447 -0.658
ENSG00000196730 E008 0.9058703 0.6823919945 6.076913e-01 7.276004e-01 9 87498535 87498610 76 + 0.381 0.137 -1.922
ENSG00000196730 E009 0.4545463 0.6221035123 3.648809e-01 5.092162e-01 9 87498611 87498636 26 + 0.264 0.000 -10.978
ENSG00000196730 E010 28.1989127 0.0133591475 2.795816e-03 9.661785e-03 9 87498970 87499004 35 + 1.558 1.314 -0.842
ENSG00000196730 E011 19.8468874 0.0131159967 4.385284e-04 1.922743e-03 9 87499005 87499005 1 + 1.436 1.111 -1.141
ENSG00000196730 E012 51.3632513 0.0062352556 8.688426e-04 3.505028e-03 9 87499006 87499139 134 + 1.794 1.607 -0.632
ENSG00000196730 E013 0.4375944 0.0274195748 1.361678e-01 2.427159e-01 9 87499140 87499352 213 + 0.263 0.000 -12.479
ENSG00000196730 E014 1.5477676 0.0098182198 3.035349e-01 4.454583e-01 9 87506820 87507002 183 + 0.324 0.517 1.048
ENSG00000196730 E015 58.1591616 0.0008863195 3.402900e-04 1.541538e-03 9 87604954 87605175 222 + 1.831 1.682 -0.504
ENSG00000196730 E016 51.9854173 0.0004764891 3.910440e-04 1.740202e-03 9 87637943 87638081 139 + 1.786 1.634 -0.514
ENSG00000196730 E017 46.6174183 0.0044574216 1.338307e-03 5.104249e-03 9 87639354 87639437 84 + 1.747 1.573 -0.590
ENSG00000196730 E018 39.1531593 0.0029705739 1.232626e-01 2.246324e-01 9 87639438 87639483 46 + 1.632 1.559 -0.247
ENSG00000196730 E019 38.6117116 0.0263346106 3.569164e-01 5.013215e-01 9 87639650 87639698 49 + 1.630 1.552 -0.267
ENSG00000196730 E020 4.4317784 0.0039597536 1.124016e-02 3.173875e-02 9 87639699 87639788 90 + 0.867 0.518 -1.473
ENSG00000196730 E021 37.1238887 0.0018532180 4.842693e-03 1.549326e-02 9 87639789 87639815 27 + 1.645 1.499 -0.500
ENSG00000196730 E022 64.8346474 0.0003727506 1.300562e-04 6.590897e-04 9 87640298 87640450 153 + 1.881 1.737 -0.487
ENSG00000196730 E023 42.5830813 0.0016431507 7.806130e-04 3.189667e-03 9 87640802 87640847 46 + 1.711 1.544 -0.567
ENSG00000196730 E024 54.3243660 0.0004137297 3.718411e-04 1.665426e-03 9 87641969 87642058 90 + 1.807 1.660 -0.497
ENSG00000196730 E025 46.7775620 0.0010581509 5.213570e-02 1.129608e-01 9 87643376 87643468 93 + 1.713 1.634 -0.268
ENSG00000196730 E026 55.6235347 0.0004502041 1.622357e-02 4.321822e-02 9 87645895 87646014 120 + 1.792 1.702 -0.304
ENSG00000196730 E027 47.7319800 0.0023032718 1.625156e-01 2.784212e-01 9 87646461 87646559 99 + 1.713 1.660 -0.181
ENSG00000196730 E028 44.2309930 0.0064641061 9.084733e-01 9.458648e-01 9 87647305 87647403 99 + 1.648 1.661 0.042
ENSG00000196730 E029 0.2214452 0.0403991316 3.751443e-01   9 87648575 87648585 11 + 0.000 0.141 10.638
ENSG00000196730 E030 0.5503986 0.0215669348 4.210487e-01 5.641995e-01 9 87648586 87648780 195 + 0.106 0.247 1.469
ENSG00000196730 E031 46.1632460 0.0004999222 8.151541e-02 1.619219e-01 9 87648781 87648879 99 + 1.704 1.638 -0.224
ENSG00000196730 E032 42.3671997 0.0005524085 5.430986e-01 6.737503e-01 9 87649921 87649989 69 + 1.643 1.634 -0.029
ENSG00000196730 E033 64.8776749 0.0025603656 1.256663e-01 2.280955e-01 9 87649990 87650118 129 + 1.845 1.795 -0.168
ENSG00000196730 E034 2.0564378 0.0073663072 8.446553e-01 9.033285e-01 9 87650119 87650511 393 + 0.468 0.518 0.243
ENSG00000196730 E035 78.8029922 0.0003854565 2.479124e-01 3.834732e-01 9 87651527 87651724 198 + 1.915 1.893 -0.071
ENSG00000196730 E036 0.2214452 0.0403991316 3.751443e-01   9 87657416 87658028 613 + 0.000 0.141 10.638
ENSG00000196730 E037 53.0470427 0.0005206739 5.089147e-01 6.442954e-01 9 87658029 87658127 99 + 1.738 1.730 -0.026
ENSG00000196730 E038 0.2966881 0.0290785164 2.871238e-01   9 87667778 87668047 270 + 0.191 0.000 -11.900
ENSG00000196730 E039 0.0000000       9 87668453 87668596 144 +      
ENSG00000196730 E040 41.9452728 0.0005293145 6.107012e-01 7.299890e-01 9 87668597 87668674 78 + 1.637 1.634 -0.011
ENSG00000196730 E041 0.0000000       9 87668675 87668948 274 +      
ENSG00000196730 E042 72.6136968 0.0004015500 4.494235e-01 5.906277e-01 9 87681404 87681626 223 + 1.870 1.863 -0.024
ENSG00000196730 E043 71.4394679 0.0008008350 4.625782e-01 6.024408e-01 9 87686551 87686739 189 + 1.863 1.856 -0.025
ENSG00000196730 E044 76.8497070 0.0003527529 4.072006e-01 5.507967e-01 9 87697007 87697204 198 + 1.865 1.922 0.192
ENSG00000196730 E045 1.5749379 0.0235232302 8.351520e-01 8.968356e-01 9 87698409 87698655 247 + 0.425 0.403 -0.119
ENSG00000196730 E046 71.1013416 0.0004081187 9.435166e-01 9.685555e-01 9 87698656 87698794 139 + 1.845 1.872 0.091
ENSG00000196730 E047 58.6959925 0.0006891645 8.526476e-01 9.086883e-01 9 87700117 87700237 121 + 1.768 1.783 0.051
ENSG00000196730 E048 64.1248963 0.0004357511 9.947429e-01 1.000000e+00 9 87703029 87703217 189 + 1.803 1.827 0.080
ENSG00000196730 E049 260.5701849 0.0037277587 6.322319e-03 1.946318e-02 9 87706132 87707360 1229 + 2.360 2.479 0.396
ENSG00000196730 E050 132.6378751 0.0005105335 3.091089e-17 1.416540e-15 9 87707361 87707836 476 + 1.968 2.259 0.972
ENSG00000196730 E051 242.7285714 0.0050034486 8.804734e-18 4.360864e-16 9 87707837 87708678 842 + 2.186 2.543 1.191