ENSG00000196700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369888 ENSG00000196700 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF512B protein_coding protein_coding 32.89757 39.53551 27.61821 3.249793 0.5211741 -0.5173719 16.669912 30.9565198 10.077895 1.84036780 0.2354717 -1.6180841 0.47638333 0.787266667 0.36486667 -0.42240000 3.312797e-12 1.573131e-31 FALSE TRUE
MSTRG.21005.11 ENSG00000196700 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF512B protein_coding   32.89757 39.53551 27.61821 3.249793 0.5211741 -0.5173719 4.275959 1.1645125 5.943211 0.34748616 0.4040435 2.3416060 0.14240417 0.028366667 0.21480000 0.18643333 9.920975e-11 1.573131e-31 FALSE TRUE
MSTRG.21005.17 ENSG00000196700 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF512B protein_coding   32.89757 39.53551 27.61821 3.249793 0.5211741 -0.5173719 1.284433 0.1821154 2.669589 0.05608801 0.0651763 3.8019663 0.04682083 0.004433333 0.09666667 0.09223333 1.573131e-31 1.573131e-31 FALSE TRUE
MSTRG.21005.18 ENSG00000196700 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF512B protein_coding   32.89757 39.53551 27.61821 3.249793 0.5211741 -0.5173719 2.965868 1.6063910 1.831216 0.22399637 0.3063107 0.1878829 0.09331250 0.041133333 0.06653333 0.02540000 3.058730e-01 1.573131e-31   FALSE
MSTRG.21005.7 ENSG00000196700 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF512B protein_coding   32.89757 39.53551 27.61821 3.249793 0.5211741 -0.5173719 3.356976 1.6137482 3.229619 0.81578697 0.1875701 0.9964962 0.10886667 0.039733333 0.11676667 0.07703333 3.988030e-02 1.573131e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196700 E001 0.0000000       20 63956472 63956580 109 -      
ENSG00000196700 E002 0.0000000       20 63956581 63956605 25 -      
ENSG00000196700 E003 0.3666179 0.0289697803 6.925554e-01 7.937670e-01 20 63956606 63956703 98 - 0.151 0.099 -0.694
ENSG00000196700 E004 694.7454052 0.0029701605 9.515663e-20 5.870120e-18 20 63956704 63957425 722 - 2.597 2.898 1.002
ENSG00000196700 E005 505.4564015 0.0030945293 2.954354e-13 7.855347e-12 20 63957426 63957877 452 - 2.489 2.752 0.874
ENSG00000196700 E006 308.9131033 0.0023253154 4.048033e-07 3.646810e-06 20 63957878 63958134 257 - 2.329 2.521 0.640
ENSG00000196700 E007 1681.0649994 0.0009778540 2.855755e-10 4.665121e-09 20 63958135 63959705 1571 - 3.111 3.239 0.427
ENSG00000196700 E008 139.5230937 0.0019993799 3.798441e-03 1.257762e-02 20 63959706 63959741 36 - 2.016 2.159 0.478
ENSG00000196700 E009 112.5718653 0.0016120114 3.096950e-04 1.418951e-03 20 63959742 63959755 14 - 1.897 2.075 0.597
ENSG00000196700 E010 490.7291124 0.0020737031 1.996969e-01 3.258513e-01 20 63959756 63960139 384 - 2.620 2.686 0.220
ENSG00000196700 E011 6.0082239 0.0552898114 8.465477e-03 2.495151e-02 20 63960290 63960374 85 - 1.040 0.638 -1.574
ENSG00000196700 E012 19.3514010 0.0060825458 2.664044e-03 9.264882e-03 20 63960798 63961308 511 - 1.426 1.199 -0.796
ENSG00000196700 E013 276.4301996 0.0046612755 1.951129e-01 3.201250e-01 20 63961309 63961407 99 - 2.430 2.410 -0.068
ENSG00000196700 E014 213.6960324 0.0002515427 1.283863e-03 4.922963e-03 20 63961942 63962004 63 - 2.339 2.283 -0.186
ENSG00000196700 E015 249.4665449 0.0001800426 1.201066e-04 6.144464e-04 20 63962273 63962374 102 - 2.410 2.346 -0.212
ENSG00000196700 E016 273.4336548 0.0015726790 2.656565e-03 9.242772e-03 20 63962587 63962781 195 - 2.447 2.390 -0.193
ENSG00000196700 E017 211.5281332 0.0002141782 3.924450e-01 5.364063e-01 20 63963095 63963242 148 - 2.295 2.300 0.015
ENSG00000196700 E018 105.1079381 0.0002655533 2.419667e-01 3.765112e-01 20 63963243 63963265 23 - 1.949 2.018 0.234
ENSG00000196700 E019 138.8708164 0.0002393436 9.971088e-01 1.000000e+00 20 63963342 63963380 39 - 2.099 2.126 0.089
ENSG00000196700 E020 170.5378156 0.0003397339 1.455575e-01 2.556216e-01 20 63963381 63963440 60 - 2.214 2.199 -0.052
ENSG00000196700 E021 222.4200874 0.0001857203 1.653668e-02 4.392076e-02 20 63963618 63963710 93 - 2.340 2.307 -0.111
ENSG00000196700 E022 253.6354644 0.0001624405 5.331942e-01 6.654284e-01 20 63963789 63963913 125 - 2.370 2.382 0.040
ENSG00000196700 E023 259.9540804 0.0004059440 2.517057e-01 3.879785e-01 20 63964071 63964217 147 - 2.353 2.408 0.185
ENSG00000196700 E024 181.2935469 0.0003685909 2.940922e-01 4.351786e-01 20 63964320 63964391 72 - 2.233 2.230 -0.010
ENSG00000196700 E025 5.8345849 0.0027849075 3.528937e-03 1.180969e-02 20 63964392 63964395 4 - 1.005 0.661 -1.349
ENSG00000196700 E026 267.2776587 0.0050283979 1.949747e-01 3.199537e-01 20 63964490 63964716 227 - 2.413 2.395 -0.060
ENSG00000196700 E027 250.1663686 0.0023305616 5.327742e-04 2.282456e-03 20 63966141 63966281 141 - 2.425 2.343 -0.271
ENSG00000196700 E028 284.4023169 0.0001727176 5.226305e-14 1.547527e-12 20 63966282 63966424 143 - 2.513 2.376 -0.456
ENSG00000196700 E029 150.6141994 0.0003055293 2.402763e-14 7.472033e-13 20 63966425 63966443 19 - 2.273 2.073 -0.670
ENSG00000196700 E030 198.2541507 0.0001841300 1.929507e-10 3.241172e-09 20 63966444 63966496 53 - 2.357 2.219 -0.461
ENSG00000196700 E031 394.4138361 0.0012192824 1.466139e-09 2.106284e-08 20 63966497 63966781 285 - 2.643 2.527 -0.388
ENSG00000196700 E032 230.9565916 0.0037451831 1.015082e-05 6.735231e-05 20 63966876 63967004 129 - 2.423 2.289 -0.447
ENSG00000196700 E033 207.4599982 0.0038101785 2.506382e-06 1.908774e-05 20 63967381 63967523 143 - 2.386 2.236 -0.500
ENSG00000196700 E034 126.7954935 0.0045828455 3.107917e-07 2.866113e-06 20 63967830 63967952 123 - 2.200 1.999 -0.671
ENSG00000196700 E035 26.2690677 0.0320536133 4.725400e-07 4.200117e-06 20 63967953 63968145 193 - 1.676 1.161 -1.783
ENSG00000196700 E036 26.6101696 0.0010172777 5.088338e-12 1.112231e-10 20 63968484 63968646 163 - 1.648 1.207 -1.527
ENSG00000196700 E037 38.0552170 0.0014315071 5.598515e-11 1.030430e-09 20 63968647 63968878 232 - 1.762 1.404 -1.222
ENSG00000196700 E038 20.2909989 0.0073479714 2.474539e-06 1.887331e-05 20 63969129 63969241 113 - 1.506 1.133 -1.303
ENSG00000196700 E039 8.4552446 0.0019272191 1.847876e-07 1.782548e-06 20 63969518 63969813 296 - 1.235 0.684 -2.076
ENSG00000196700 E040 22.6242462 0.0010071871 1.112455e-03 4.345295e-03 20 63969814 63969936 123 - 1.471 1.259 -0.739