ENSG00000196693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359467 ENSG00000196693 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33B protein_coding protein_coding 8.129703 4.193677 11.92039 0.4264956 0.6111158 1.504918 3.0813812 1.0598835 5.0632098 0.17538366 0.113577404 2.24544513 0.35482500 0.24976667 0.4262667 0.17650000 0.0005698173 0.0005698173 FALSE TRUE
ENST00000486187 ENSG00000196693 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33B protein_coding processed_transcript 8.129703 4.193677 11.92039 0.4264956 0.6111158 1.504918 1.5193769 1.5606118 1.8952295 0.09768459 0.181297329 0.27863811 0.23837083 0.38296667 0.1601333 -0.22283333 0.0045562336 0.0005698173 TRUE FALSE
ENST00000493285 ENSG00000196693 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33B protein_coding protein_coding 8.129703 4.193677 11.92039 0.4264956 0.6111158 1.504918 0.6119359 0.3301762 0.3138366 0.22486952 0.009677273 -0.07101632 0.06670833 0.07010000 0.0264000 -0.04370000 0.8416820588 0.0005698173 FALSE FALSE
MSTRG.3829.10 ENSG00000196693 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33B protein_coding   8.129703 4.193677 11.92039 0.4264956 0.6111158 1.504918 1.5439607 0.7068748 2.7885543 0.15494609 0.263466941 1.96488872 0.16049583 0.16783333 0.2334333 0.06560000 0.4285925886 0.0005698173 FALSE TRUE
MSTRG.3829.4 ENSG00000196693 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF33B protein_coding   8.129703 4.193677 11.92039 0.4264956 0.6111158 1.504918 0.1787441 0.3193066 0.1218385 0.09610785 0.121838511 -1.32065971 0.03170417 0.07693333 0.0108000 -0.06613333 0.1135067808 0.0005698173 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196693 E001 1.8454748 0.0959325622 2.885487e-01 4.291482e-01 10 42574185 42574411 227 - 0.382 0.555 0.873
ENSG00000196693 E002 1.8455766 0.0076532565 9.797932e-01 9.914267e-01 10 42574412 42574547 136 - 0.450 0.410 -0.208
ENSG00000196693 E003 1.2973666 0.0106775740 9.822972e-01 9.929835e-01 10 42574548 42574554 7 - 0.345 0.312 -0.207
ENSG00000196693 E004 2.7690521 0.0053947433 4.162000e-01 5.595794e-01 10 42574555 42574678 124 - 0.605 0.411 -0.945
ENSG00000196693 E005 57.0500173 0.0040337734 9.715507e-24 9.366787e-22 10 42581594 42582690 1097 - 1.530 1.991 1.557
ENSG00000196693 E006 7.8356668 0.0501039842 7.639729e-02 1.537408e-01 10 42582691 42582751 61 - 0.849 1.055 0.771
ENSG00000196693 E007 28.5677034 0.0148589307 5.734538e-06 4.026952e-05 10 42582752 42583123 372 - 1.318 1.635 1.091
ENSG00000196693 E008 0.2944980 0.3818452737 8.680623e-01   10 42589107 42589108 2 - 0.147 0.000 -9.354
ENSG00000196693 E009 408.8823629 0.0087910171 1.096007e-07 1.105371e-06 10 42589109 42594594 5486 - 2.636 2.429 -0.688
ENSG00000196693 E010 35.4820220 0.0019958795 9.494309e-01 9.723372e-01 10 42594595 42594699 105 - 1.555 1.482 -0.250
ENSG00000196693 E011 3.3601496 0.0047179920 8.330152e-01 8.953806e-01 10 42613888 42613968 81 - 0.647 0.559 -0.389
ENSG00000196693 E012 19.5694946 0.0010937960 6.327423e-01 7.475452e-01 10 42614282 42614358 77 - 1.318 1.210 -0.380
ENSG00000196693 E013 0.1482932 0.0415321054 1.516312e-01   10 42631808 42631928 121 - 0.000 0.183 10.269
ENSG00000196693 E014 44.6739420 0.0073454666 9.008608e-01 9.407755e-01 10 42631929 42632024 96 - 1.655 1.576 -0.270
ENSG00000196693 E015 53.1229416 0.0028386014 4.976923e-01 6.342327e-01 10 42632295 42632439 145 - 1.731 1.623 -0.367
ENSG00000196693 E016 0.0000000       10 42632904 42632912 9 -      
ENSG00000196693 E017 0.0000000       10 42636826 42636919 94 -      
ENSG00000196693 E018 40.0464218 0.0005345098 3.730352e-01 5.174705e-01 10 42636920 42636972 53 - 1.586 1.570 -0.053
ENSG00000196693 E019 38.2051948 0.0006350436 1.442786e-01 2.538254e-01 10 42638474 42638627 154 - 1.551 1.571 0.069