ENSG00000196668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000470091 ENSG00000196668 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00173 lncRNA lncRNA 0.5323475 0.4505607 0.3578828 0.05513392 0.09431838 -0.3241451 0.006008167 0.04806533 0.00000000 0.048065335 0.000000000 -2.5376771 0.01272917 0.1018333 0.00000000 -0.10183333 0.78206496 0.02345501   FALSE
ENST00000477702 ENSG00000196668 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00173 lncRNA retained_intron 0.5323475 0.4505607 0.3578828 0.05513392 0.09431838 -0.3241451 0.036996799 0.00000000 0.17998283 0.000000000 0.090002475 4.2477971 0.06178333 0.0000000 0.41393333 0.41393333 0.09461463 0.02345501   FALSE
ENST00000480237 ENSG00000196668 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00173 lncRNA lncRNA 0.5323475 0.4505607 0.3578828 0.05513392 0.09431838 -0.3241451 0.129089854 0.07464913 0.09119277 0.008763245 0.008456048 0.2575392 0.23355833 0.1715000 0.29830000 0.12680000 0.70691756 0.02345501 FALSE FALSE
ENST00000489452 ENSG00000196668 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00173 lncRNA lncRNA 0.5323475 0.4505607 0.3578828 0.05513392 0.09431838 -0.3241451 0.075185911 0.23823338 0.03583526 0.051593755 0.035835262 -2.4371673 0.15787083 0.5279000 0.07043333 -0.45746667 0.02345501 0.02345501   FALSE
ENST00000659479 ENSG00000196668 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00173 lncRNA lncRNA 0.5323475 0.4505607 0.3578828 0.05513392 0.09431838 -0.3241451 0.285066797 0.08961282 0.05087191 0.011140921 0.029384641 -0.7105548 0.53405000 0.1987667 0.21733333 0.01856667 0.88898688 0.02345501 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196668 E001 0.2214452 0.044073573 1.00000000   12 116533422 116533434 13 + 0.000 0.091 10.175
ENSG00000196668 E002 0.5848540 0.025224110 0.33802260 0.48189703 12 116533435 116533462 28 + 0.000 0.231 12.865
ENSG00000196668 E003 0.4031496 0.028920049 0.58955518 0.71260608 12 116533463 116533467 5 + 0.000 0.167 12.353
ENSG00000196668 E004 1.4758462 0.010876605 0.24525810 0.38034259 12 116533468 116533616 149 + 0.162 0.421 1.854
ENSG00000196668 E005 1.9541369 0.008735017 0.08351588 0.16505146 12 116533966 116534359 394 + 0.162 0.523 2.367
ENSG00000196668 E006 2.9161968 0.015378759 0.00505327 0.01607737 12 116534360 116535422 1063 + 0.743 0.458 -1.277
ENSG00000196668 E007 0.2965864 0.050899139 0.59260616   12 116535423 116535521 99 + 0.000 0.166 12.340
ENSG00000196668 E008 0.7331471 0.017954378 0.20235210 0.32916185 12 116535522 116536063 542 + 0.000 0.287 13.240
ENSG00000196668 E009 0.3268771 0.033420499 0.49548430   12 116536064 116536119 56 + 0.162 0.091 -0.954
ENSG00000196668 E010 0.8052696 0.021479869 0.13798485 0.24527173 12 116536120 116536211 92 + 0.373 0.167 -1.539
ENSG00000196668 E011 0.8846626 0.015549545 0.65328304 0.76380110 12 116536353 116536513 161 + 0.162 0.287 1.046
ENSG00000196668 E012 0.1515154 0.050579776 0.18609758   12 116536514 116536518 5 + 0.162 0.000 -13.287