ENSG00000196663

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359520 ENSG00000196663 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR2 protein_coding protein_coding 6.246207 7.499186 5.865047 0.572665 0.1578196 -0.3540563 2.2346049 3.544420 2.0626454 0.4639115 0.10643686 -0.7781407 0.34755000 0.4697000 0.3529000 -0.11680000 2.058409e-01 4.577817e-10 FALSE TRUE
ENST00000557786 ENSG00000196663 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR2 protein_coding processed_transcript 6.246207 7.499186 5.865047 0.572665 0.1578196 -0.3540563 0.1422136 0.000000 0.7115547 0.0000000 0.16537109 6.1730369 0.02344583 0.0000000 0.1200000 0.12000000 4.577817e-10 4.577817e-10   FALSE
ENST00000558678 ENSG00000196663 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR2 protein_coding protein_coding 6.246207 7.499186 5.865047 0.572665 0.1578196 -0.3540563 1.5824019 1.577068 1.4276785 0.2923033 0.01801542 -0.1426233 0.26293333 0.2077000 0.2437667 0.03606667 6.849138e-01 4.577817e-10 FALSE TRUE
ENST00000559124 ENSG00000196663 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR2 protein_coding retained_intron 6.246207 7.499186 5.865047 0.572665 0.1578196 -0.3540563 0.3230978 1.148555 0.0000000 0.2275478 0.00000000 -6.8561821 0.04696667 0.1593667 0.0000000 -0.15936667 2.784063e-08 4.577817e-10 FALSE FALSE
MSTRG.10214.2 ENSG00000196663 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR2 protein_coding   6.246207 7.499186 5.865047 0.572665 0.1578196 -0.3540563 1.7012445 1.042218 1.4328046 0.2203581 0.12990715 0.4554429 0.27758333 0.1362000 0.2457667 0.10956667 8.366904e-02 4.577817e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196663 E001 1.0361780 0.0144772975 7.307530e-01 8.225873e-01 14 102362941 102362958 18 + 0.250 0.320 0.489
ENSG00000196663 E002 1.9187537 0.0077333487 2.138149e-01 3.430265e-01 14 102362959 102362966 8 + 0.571 0.373 -0.997
ENSG00000196663 E003 6.5602816 0.0025563571 3.591150e-01 5.034524e-01 14 102362967 102363060 94 + 0.923 0.828 -0.367
ENSG00000196663 E004 7.1451395 0.0044141219 4.382422e-02 9.806371e-02 14 102363061 102363078 18 + 1.030 0.809 -0.835
ENSG00000196663 E005 15.1873355 0.0258987861 3.555098e-02 8.271041e-02 14 102363079 102363116 38 + 1.318 1.105 -0.756
ENSG00000196663 E006 53.2823235 0.0162398515 2.243305e-03 7.977539e-03 14 102376650 102376940 291 + 1.842 1.633 -0.707
ENSG00000196663 E007 38.4263399 0.0016170284 7.557027e-05 4.069864e-04 14 102407338 102407466 129 + 1.702 1.491 -0.719
ENSG00000196663 E008 36.8253989 0.0061389621 1.214747e-05 7.913964e-05 14 102408488 102408619 132 + 1.718 1.445 -0.931
ENSG00000196663 E009 43.1632982 0.0009418768 3.192094e-05 1.886900e-04 14 102414636 102414793 158 + 1.750 1.545 -0.696
ENSG00000196663 E010 27.9311630 0.0007385960 1.271748e-04 6.464418e-04 14 102424979 102425010 32 + 1.574 1.342 -0.799
ENSG00000196663 E011 66.2563012 0.0059026998 3.436119e-02 8.044817e-02 14 102425011 102425291 281 + 1.867 1.770 -0.326
ENSG00000196663 E012 48.9071818 0.0137477917 8.930159e-01 9.356335e-01 14 102428250 102428382 133 + 1.671 1.683 0.041
ENSG00000196663 E013 69.3364750 0.0003601133 5.137187e-01 6.484923e-01 14 102431796 102432128 333 + 1.836 1.826 -0.035
ENSG00000196663 E014 129.2948811 0.0002761589 1.802828e-03 6.608242e-03 14 102434235 102434838 604 + 2.146 2.068 -0.264
ENSG00000196663 E015 51.9370937 0.0004543085 7.492326e-03 2.249265e-02 14 102434839 102434936 98 + 1.773 1.660 -0.382
ENSG00000196663 E016 59.5833811 0.0004675535 5.548249e-01 6.837618e-01 14 102434937 102435119 183 + 1.767 1.757 -0.033
ENSG00000196663 E017 39.4272613 0.0010761951 8.498210e-01 9.068096e-01 14 102435120 102435211 92 + 1.583 1.590 0.024
ENSG00000196663 E018 47.9825126 0.0004983393 9.730879e-01 9.871992e-01 14 102438022 102438205 184 + 1.660 1.675 0.053
ENSG00000196663 E019 1.1093195 0.0113635162 1.393025e-02 3.806498e-02 14 102438277 102438463 187 + 0.523 0.105 -3.095
ENSG00000196663 E020 64.0862073 0.0004006664 3.368458e-01 4.807077e-01 14 102440436 102440609 174 + 1.753 1.814 0.206
ENSG00000196663 E021 80.6278529 0.0003619064 6.589257e-01 7.678867e-01 14 102443647 102443827 181 + 1.892 1.892 0.000
ENSG00000196663 E022 68.3214599 0.0012832919 4.590225e-01 5.992560e-01 14 102445806 102445947 142 + 1.829 1.812 -0.055
ENSG00000196663 E023 85.9469102 0.0038253863 3.192562e-01 4.623168e-01 14 102449629 102449869 241 + 1.874 1.941 0.227
ENSG00000196663 E024 50.6430033 0.0005173344 6.408881e-01 7.540288e-01 14 102450560 102450649 90 + 1.663 1.705 0.140
ENSG00000196663 E025 75.4788181 0.0004387393 1.861864e-02 4.849579e-02 14 102452394 102452627 234 + 1.784 1.902 0.398
ENSG00000196663 E026 65.5976930 0.0003942793 6.956257e-02 1.426390e-01 14 102465141 102465289 149 + 1.740 1.840 0.336
ENSG00000196663 E027 9.6030750 0.0212788079 3.850287e-06 2.812080e-05 14 102465290 102465671 382 + 0.469 1.170 2.828
ENSG00000196663 E028 0.9869609 0.1196693942 7.036853e-01 8.023586e-01 14 102496881 102496978 98 + 0.335 0.260 -0.504
ENSG00000196663 E029 60.2296928 0.0003903707 7.381904e-01 8.281299e-01 14 102496979 102497120 142 + 1.746 1.779 0.111
ENSG00000196663 E030 1.9812054 0.0075328183 2.128052e-02 5.417778e-02 14 102497539 102497569 31 + 0.143 0.571 2.812
ENSG00000196663 E031 56.1727984 0.0041296175 6.416284e-01 7.546177e-01 14 102497570 102497719 150 + 1.715 1.759 0.147
ENSG00000196663 E032 492.2959699 0.0038808027 2.872753e-06 2.158376e-05 14 102498103 102501675 3573 + 2.577 2.725 0.494
ENSG00000196663 E033 51.2074186 0.0006762729 1.436389e-03 5.427739e-03 14 102501676 102502477 802 + 1.570 1.755 0.630