ENSG00000196591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368632 ENSG00000196591 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC2 protein_coding protein_coding 167.4898 71.90131 286.1974 5.426409 8.960329 1.99277 31.39293 11.62616 59.54602 0.9603112 4.420977 2.355633 0.1836917 0.1629667 0.2094333 0.04646667 0.43516261 0.00892909 FALSE TRUE
ENST00000425835 ENSG00000196591 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC2 protein_coding protein_coding 167.4898 71.90131 286.1974 5.426409 8.960329 1.99277 43.82112 13.16234 76.92845 1.0405762 4.446899 2.546194 0.2377667 0.1847333 0.2688667 0.08413333 0.04273073 0.00892909 FALSE TRUE
MSTRG.28844.5 ENSG00000196591 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC2 protein_coding   167.4898 71.90131 286.1974 5.426409 8.960329 1.99277 83.86987 45.90429 130.95867 4.7129021 15.376190 1.512207 0.5330292 0.6358000 0.4551667 -0.18063333 0.00892909 0.00892909 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196591 E001 155.2818692 8.488683e-04 7.488450e-11 1.347644e-09 6 113933028 113940717 7690 - 2.069 2.296 0.759
ENSG00000196591 E002 11.0957183 4.628333e-02 6.718275e-07 5.789207e-06 6 113940718 113940718 1 - 0.722 1.427 2.589
ENSG00000196591 E003 941.4089854 1.562995e-03 1.370634e-66 1.790775e-63 6 113940719 113941088 370 - 2.780 3.171 1.301
ENSG00000196591 E004 851.6060317 1.222307e-03 3.208448e-09 4.330205e-08 6 113941708 113941765 58 - 2.838 2.977 0.461
ENSG00000196591 E005 1528.8773349 1.707088e-04 8.391231e-07 7.085459e-06 6 113943351 113943506 156 - 3.114 3.183 0.230
ENSG00000196591 E006 1367.0880001 6.228828e-05 2.112690e-02 5.386630e-02 6 113944280 113944410 131 - 3.074 3.112 0.127
ENSG00000196591 E007 622.8148430 2.525831e-04 5.442310e-01 6.747309e-01 6 113945362 113945379 18 - 2.743 2.744 0.006
ENSG00000196591 E008 1153.1648797 2.490559e-04 8.750274e-01 9.237056e-01 6 113945380 113945470 91 - 3.007 3.017 0.033
ENSG00000196591 E009 1261.4118661 6.742943e-05 2.259086e-01 3.574816e-01 6 113946008 113946148 141 - 3.042 3.069 0.090
ENSG00000196591 E010 58.9643277 8.861782e-04 4.597670e-08 4.995210e-07 6 113946149 113948978 2830 - 1.792 1.470 -1.095
ENSG00000196591 E011 949.0847594 5.781780e-04 2.906391e-01 4.314584e-01 6 113948979 113949087 109 - 2.917 2.948 0.102
ENSG00000196591 E012 2.8819701 3.591280e-02 6.706364e-01 7.770313e-01 6 113949088 113949167 80 - 0.521 0.600 0.365
ENSG00000196591 E013 868.3439526 1.473178e-03 3.974839e-01 5.412407e-01 6 113949168 113949260 93 - 2.889 2.881 -0.026
ENSG00000196591 E014 5.1622104 6.431766e-02 6.396503e-01 7.529972e-01 6 113949261 113949323 63 - 0.723 0.834 0.443
ENSG00000196591 E015 980.7639728 1.602820e-03 2.758301e-01 4.152147e-01 6 113953277 113953399 123 - 2.943 2.929 -0.047
ENSG00000196591 E016 537.7195423 1.953879e-03 7.835817e-02 1.568463e-01 6 113953400 113953418 19 - 2.689 2.648 -0.136
ENSG00000196591 E017 2.5936905 5.833097e-03 2.197064e-01 3.500412e-01 6 113955927 113956012 86 - 0.565 0.340 -1.168
ENSG00000196591 E018 927.8877391 1.582817e-04 3.983722e-03 1.309727e-02 6 113956013 113956109 97 - 2.923 2.893 -0.098
ENSG00000196591 E019 527.0727066 8.967743e-04 6.932479e-05 3.767571e-04 6 113956110 113956118 9 - 2.689 2.607 -0.274
ENSG00000196591 E020 622.0389487 7.420321e-04 4.001180e-05 2.306230e-04 6 113956119 113956151 33 - 2.760 2.683 -0.257
ENSG00000196591 E021 4.9034034 3.829846e-02 5.747857e-01 7.005412e-01 6 113956152 113956602 451 - 0.751 0.659 -0.384
ENSG00000196591 E022 517.0066496 8.922159e-04 3.277726e-05 1.931973e-04 6 113956619 113956628 10 - 2.682 2.595 -0.290
ENSG00000196591 E023 532.8219531 3.734231e-04 2.847174e-06 2.141876e-05 6 113956629 113956669 41 - 2.695 2.611 -0.277
ENSG00000196591 E024 315.0031644 1.451225e-04 4.782617e-04 2.076863e-03 6 113956670 113956673 4 - 2.464 2.394 -0.235
ENSG00000196591 E025 427.2833058 1.197404e-04 9.340234e-07 7.799482e-06 6 113956674 113956689 16 - 2.601 2.513 -0.295
ENSG00000196591 E026 370.0888407 1.323935e-04 1.176117e-05 7.688470e-05 6 113956690 113956693 4 - 2.538 2.453 -0.281
ENSG00000196591 E027 7.6621481 3.990004e-02 3.452628e-02 8.076283e-02 6 113956694 113957286 593 - 0.963 0.599 -1.462
ENSG00000196591 E028 4.9984166 6.355718e-03 7.891608e-03 2.350694e-02 6 113958427 113958648 222 - 0.814 0.340 -2.215
ENSG00000196591 E029 485.8722235 1.300778e-04 6.638160e-08 6.980348e-07 6 113958649 113958661 13 - 2.657 2.564 -0.310
ENSG00000196591 E030 495.0398823 2.565367e-04 1.763027e-06 1.387966e-05 6 113958662 113958683 22 - 2.664 2.580 -0.278
ENSG00000196591 E031 637.8037715 1.990997e-04 5.752544e-12 1.244919e-10 6 113958684 113958766 83 - 2.780 2.669 -0.368
ENSG00000196591 E032 0.5933762 2.104354e-02 3.198505e-01 4.629226e-01 6 113959610 113959905 296 - 0.234 0.000 -10.104
ENSG00000196591 E033 549.5835868 6.592562e-04 1.194815e-05 7.798297e-05 6 113959906 113960018 113 - 2.708 2.625 -0.277
ENSG00000196591 E034 0.6955713 1.736097e-02 2.542259e-01 3.908709e-01 6 113960019 113960039 21 - 0.132 0.341 1.741
ENSG00000196591 E035 2.8012923 5.433929e-02 2.269601e-01 3.587650e-01 6 113962367 113962394 28 - 0.585 0.342 -1.249
ENSG00000196591 E036 0.4355181 5.669217e-01 7.956525e-01 8.695204e-01 6 113968330 113968633 304 - 0.185 0.001 -8.839
ENSG00000196591 E037 2.1370810 6.913221e-03 3.928655e-01 5.367565e-01 6 113968634 113968696 63 - 0.497 0.340 -0.846
ENSG00000196591 E038 0.0000000       6 113970255 113970479 225 -      
ENSG00000196591 E039 2.0565290 1.353113e-02 1.087063e-01 2.036235e-01 6 113970480 113970856 377 - 0.520 0.202 -1.963
ENSG00000196591 E040 741.2386370 3.896135e-03 8.532674e-05 4.532044e-04 6 113970857 113971157 301 - 2.847 2.721 -0.419
ENSG00000196591 E041 0.0000000       6 114011131 114011308 178 -