ENSG00000196586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369975 ENSG00000196586 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO6 protein_coding protein_coding 5.766159 1.872821 10.3023 0.1405846 0.5370865 2.453399 3.17095392 1.549246 5.001372 0.08931267 0.2438810 1.684357 0.66721250 0.8366333 0.4891667 -0.3474667 4.476648e-02 3.565235e-10 FALSE TRUE
ENST00000615563 ENSG00000196586 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO6 protein_coding protein_coding 5.766159 1.872821 10.3023 0.1405846 0.5370865 2.453399 0.03319455 0.235264 0.000000 0.10629073 0.0000000 -4.616263 0.01637917 0.1192667 0.0000000 -0.1192667 2.256232e-05 3.565235e-10 FALSE TRUE
ENST00000627432 ENSG00000196586 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO6 protein_coding protein_coding 5.766159 1.872821 10.3023 0.1405846 0.5370865 2.453399 1.82897338 0.000000 4.258995 0.00000000 0.9107676 8.737753 0.19160417 0.0000000 0.4072333 0.4072333 3.565235e-10 3.565235e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196586 E001 1.0801878 0.0633136158 7.474211e-01 8.349339e-01 6 75749201 75749201 1 + 0.271 0.239 -0.239
ENSG00000196586 E002 1.0801878 0.0633136158 7.474211e-01 8.349339e-01 6 75749202 75749204 3 + 0.271 0.239 -0.239
ENSG00000196586 E003 2.1238439 0.0913442255 2.556987e-01 3.926159e-01 6 75749205 75749234 30 + 0.460 0.239 -1.356
ENSG00000196586 E004 2.1175012 0.0317760777 2.156275e-01 3.451620e-01 6 75749235 75749235 1 + 0.459 0.239 -1.355
ENSG00000196586 E005 2.1175012 0.0317760777 2.156275e-01 3.451620e-01 6 75749236 75749238 3 + 0.459 0.239 -1.355
ENSG00000196586 E006 2.1175012 0.0317760777 2.156275e-01 3.451620e-01 6 75749239 75749245 7 + 0.459 0.239 -1.355
ENSG00000196586 E007 8.9218447 0.0026529404 2.102571e-05 1.297605e-04 6 75749246 75749261 16 + 0.978 0.239 -3.536
ENSG00000196586 E008 18.5804862 0.0010651116 7.051535e-09 8.943510e-08 6 75749262 75749314 53 + 1.270 0.505 -2.999
ENSG00000196586 E009 26.8175871 0.0007095075 2.669929e-08 3.035893e-07 6 75749315 75749423 109 + 1.407 0.881 -1.893
ENSG00000196586 E010 0.1515154 0.0427361433 1.000000e+00   6 75757999 75758120 122 + 0.059 0.000 -14.108
ENSG00000196586 E011 0.1515154 0.0427361433 1.000000e+00   6 75777453 75777570 118 + 0.059 0.000 -14.108
ENSG00000196586 E012 0.1472490 0.0435505065 1.000000e+00   6 75813599 75813688 90 + 0.059 0.000 -14.108
ENSG00000196586 E013 16.9491286 0.0010851433 3.379492e-06 2.501894e-05 6 75817501 75817515 15 + 1.220 0.669 -2.087
ENSG00000196586 E014 15.2474625 0.0011575282 1.189670e-04 6.091667e-04 6 75817516 75817523 8 + 1.168 0.733 -1.638
ENSG00000196586 E015 16.1935246 0.0011537564 6.031661e-04 2.544637e-03 6 75817524 75817547 24 + 1.184 0.837 -1.283
ENSG00000196586 E016 29.9785485 0.0586708699 1.721675e-02 4.542326e-02 6 75817548 75817664 117 + 1.427 1.182 -0.854
ENSG00000196586 E017 0.1515154 0.0427361433 1.000000e+00   6 75819773 75819872 100 + 0.059 0.000 -14.108
ENSG00000196586 E018 26.3552611 0.0053806674 1.298010e-03 4.969969e-03 6 75822782 75822851 70 + 1.374 1.130 -0.860
ENSG00000196586 E019 28.4721799 0.0084350374 1.319149e-02 3.635566e-02 6 75828540 75828613 74 + 1.397 1.234 -0.569
ENSG00000196586 E020 34.1445847 0.0006358135 1.890486e-04 9.171260e-04 6 75830416 75830545 130 + 1.481 1.252 -0.795
ENSG00000196586 E021 24.7633782 0.0007773638 4.022122e-03 1.320336e-02 6 75832842 75832947 106 + 1.344 1.153 -0.674
ENSG00000196586 E022 0.0000000       6 75834250 75834376 127 +      
ENSG00000196586 E023 20.5432045 0.0156860211 1.561200e-03 5.833624e-03 6 75835901 75835956 56 + 1.282 0.958 -1.168
ENSG00000196586 E024 28.2717345 0.0029862138 4.805093e-04 2.085476e-03 6 75840585 75840682 98 + 1.404 1.153 -0.883
ENSG00000196586 E025 42.2997265 0.0025421777 8.591726e-02 1.688496e-01 6 75841214 75841378 165 + 1.543 1.503 -0.138
ENSG00000196586 E026 32.8648272 0.0056041832 1.657759e-01 2.827155e-01 6 75844897 75844977 81 + 1.436 1.402 -0.117
ENSG00000196586 E027 0.0000000       6 75844978 75844982 5 +      
ENSG00000196586 E028 0.0000000       6 75846968 75846976 9 +      
ENSG00000196586 E029 43.4246000 0.0005540518 9.487080e-02 1.826969e-01 6 75848351 75848531 181 + 1.552 1.522 -0.101
ENSG00000196586 E030 44.2295334 0.0005080362 4.913177e-02 1.076054e-01 6 75855139 75855283 145 + 1.562 1.513 -0.170
ENSG00000196586 E031 48.1193685 0.0004723703 2.210002e-02 5.588411e-02 6 75857097 75857254 158 + 1.599 1.532 -0.227
ENSG00000196586 E032 35.0910715 0.0030671779 5.646590e-01 6.919024e-01 6 75858902 75858993 92 + 1.445 1.483 0.133
ENSG00000196586 E033 37.1988182 0.0216096516 4.917561e-01 6.290333e-01 6 75861023 75861095 73 + 1.474 1.489 0.052
ENSG00000196586 E034 47.3971639 0.0130217432 6.318766e-02 1.320178e-01 6 75862596 75862723 128 + 1.593 1.517 -0.259
ENSG00000196586 E035 44.9941520 0.0005120696 5.917034e-02 1.252096e-01 6 75866526 75866621 96 + 1.566 1.522 -0.148
ENSG00000196586 E036 60.3513806 0.0004716130 9.699095e-02 1.858841e-01 6 75866932 75867105 174 + 1.686 1.674 -0.038
ENSG00000196586 E037 0.4741261 0.0210203930 5.454172e-01 6.757637e-01 6 75867431 75867523 93 + 0.110 0.239 1.347
ENSG00000196586 E038 31.8945628 0.0014114374 4.861702e-01 6.239736e-01 6 75870647 75870685 39 + 1.410 1.438 0.099
ENSG00000196586 E039 0.0000000       6 75871295 75871392 98 +      
ENSG00000196586 E040 50.4481438 0.0005908025 7.325140e-04 3.016336e-03 6 75873207 75873300 94 + 1.633 1.493 -0.481
ENSG00000196586 E041 54.8135591 0.0004189063 9.306308e-01 9.603622e-01 6 75879820 75879950 131 + 1.625 1.713 0.300
ENSG00000196586 E042 39.7105954 0.0005839195 7.791821e-01 8.579948e-01 6 75880043 75880120 78 + 1.483 1.585 0.347
ENSG00000196586 E043 47.0152009 0.0063704396 6.775690e-01 7.822574e-01 6 75881689 75881818 130 + 1.567 1.618 0.174
ENSG00000196586 E044 42.1369820 0.0040747450 6.001667e-01 7.214499e-01 6 75886004 75886094 91 + 1.524 1.568 0.149
ENSG00000196586 E045 56.9293065 0.0005483405 7.087010e-01 8.062918e-01 6 75886844 75886994 151 + 1.645 1.707 0.211
ENSG00000196586 E046 63.2372600 0.0008936017 1.347104e-01 2.406980e-01 6 75890057 75890209 153 + 1.702 1.701 -0.004
ENSG00000196586 E047 40.4432607 0.0021949640 2.935976e-01 4.346729e-01 6 75890210 75890265 56 + 1.515 1.522 0.025
ENSG00000196586 E048 39.8163882 0.0068515968 4.202415e-01 5.634546e-01 6 75891228 75891306 79 + 1.505 1.523 0.061
ENSG00000196586 E049 45.3877772 0.0005692245 4.107115e-01 5.543142e-01 6 75892530 75892690 161 + 1.534 1.668 0.456
ENSG00000196586 E050 1.6919834 0.0714748629 1.647338e-01 2.813437e-01 6 75893931 75894813 883 + 0.271 0.599 1.778
ENSG00000196586 E051 0.3686942 0.0300383195 2.983977e-01 4.398341e-01 6 75894814 75894840 27 + 0.059 0.239 2.349
ENSG00000196586 E052 1.2555218 0.1846457639 2.482845e-01 3.839109e-01 6 75894841 75895230 390 + 0.198 0.516 1.982
ENSG00000196586 E053 1.3996649 0.0092979354 5.126174e-01 6.475162e-01 6 75895231 75895260 30 + 0.333 0.239 -0.653
ENSG00000196586 E054 0.3030308 0.3777691518 1.000000e+00   6 75898373 75898411 39 + 0.111 0.000 -15.115
ENSG00000196586 E055 36.1880996 0.0037714079 1.212242e-02 3.382959e-02 6 75907605 75907708 104 + 1.409 1.667 0.882
ENSG00000196586 E056 46.3615261 0.0017646311 1.287278e-04 6.533716e-04 6 75908496 75908627 132 + 1.498 1.807 1.051
ENSG00000196586 E057 2.7197318 0.0057657656 3.224609e-01 4.657572e-01 6 75911672 75911698 27 + 0.436 0.669 1.084
ENSG00000196586 E058 75.6101756 0.0238315216 1.845494e-01 3.069186e-01 6 75914063 75914281 219 + 1.737 1.940 0.687
ENSG00000196586 E059 410.1369139 0.0145491323 3.447112e-09 4.625947e-08 6 75914813 75919537 4725 + 2.411 2.780 1.227