ENSG00000196576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359337 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding protein_coding 26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 4.888969 4.746838 2.7655666 1.2593209 1.1235100 -0.7772206 0.1885208 0.1366000 0.1553667 0.01876667 1.0000000000 0.0007748769 FALSE TRUE
ENST00000449103 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding protein_coding 26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 2.972374 3.892225 1.8947358 1.2772139 0.4405461 -1.0347062 0.1081750 0.1190000 0.1065333 -0.01246667 1.0000000000 0.0007748769 FALSE TRUE
ENST00000463165 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding retained_intron 26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 5.365151 11.283502 1.9347032 2.0153839 0.5501090 -2.5378711 0.1839833 0.3268000 0.1078000 -0.21900000 0.0010797091 0.0007748769 FALSE TRUE
ENST00000479701 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding retained_intron 26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 3.187786 5.484028 0.7493588 0.3541203 0.3763802 -2.8550106 0.1041208 0.1633333 0.0451000 -0.11823333 0.3611240547 0.0007748769 FALSE TRUE
MSTRG.22362.1 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding   26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 3.481844 4.696260 2.7638401 1.1407093 0.1132249 -0.7626963 0.1350625 0.1344000 0.1581333 0.02373333 0.7013205778 0.0007748769 FALSE TRUE
MSTRG.22362.7 ENSG00000196576 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB2 protein_coding   26.64722 34.25622 17.50798 2.784616 0.961527 -0.9679509 3.856963 2.156853 5.1522506 0.6679484 0.9542352 1.2523992 0.1659542 0.0607000 0.3010000 0.24030000 0.0007748769 0.0007748769 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196576 E001 6.8490834 0.0477711880 2.307213e-02 5.789793e-02 22 50274979 50274984 6 - 0.562 0.967 1.645
ENSG00000196576 E002 176.1338658 0.0092555122 3.234168e-12 7.301042e-11 22 50274985 50275187 203 - 1.880 2.309 1.437
ENSG00000196576 E003 313.5284412 0.0088346907 2.282931e-09 3.166602e-08 22 50275188 50275361 174 - 2.213 2.542 1.097
ENSG00000196576 E004 497.0425706 0.0043124914 1.031847e-12 2.527872e-11 22 50275362 50275808 447 - 2.452 2.732 0.934
ENSG00000196576 E005 213.4077278 0.0041298187 1.850257e-04 8.993139e-04 22 50275889 50275963 75 - 2.168 2.343 0.584
ENSG00000196576 E006 219.6441616 0.0038243050 6.427804e-03 1.973436e-02 22 50276629 50276704 76 - 2.216 2.344 0.428
ENSG00000196576 E007 195.1749241 0.0002196960 3.496704e-04 1.578855e-03 22 50276842 50276906 65 - 2.171 2.287 0.388
ENSG00000196576 E008 271.3968114 0.0032092669 2.445590e-03 8.599235e-03 22 50277591 50277738 148 - 2.309 2.435 0.420
ENSG00000196576 E009 259.8627652 0.0067377004 2.767630e-01 4.162473e-01 22 50277853 50278013 161 - 2.333 2.400 0.224
ENSG00000196576 E010 270.8231292 0.0045489945 4.861840e-02 1.067142e-01 22 50278117 50278271 155 - 2.329 2.426 0.323
ENSG00000196576 E011 228.2935433 0.0031631621 6.320711e-04 2.651080e-03 22 50278435 50278519 85 - 2.215 2.364 0.496
ENSG00000196576 E012 0.8815290 0.1021116281 8.126456e-01 8.811882e-01 22 50278520 50278595 76 - 0.274 0.237 -0.277
ENSG00000196576 E013 230.1499645 0.0002857682 1.805122e-07 1.745098e-06 22 50278596 50278696 101 - 2.210 2.366 0.520
ENSG00000196576 E014 1.1415822 0.0120338039 3.339846e-01 4.777546e-01 22 50278697 50278840 144 - 0.159 0.343 1.450
ENSG00000196576 E015 285.3187657 0.0002406090 4.033183e-05 2.322556e-04 22 50278855 50279011 157 - 2.335 2.449 0.378
ENSG00000196576 E016 282.6333689 0.0015060487 6.532908e-02 1.355857e-01 22 50279630 50279776 147 - 2.364 2.436 0.241
ENSG00000196576 E017 177.3895734 0.0030448286 7.079226e-01 8.056819e-01 22 50280005 50280071 67 - 2.190 2.223 0.111
ENSG00000196576 E018 261.0731436 0.0004755731 8.077535e-01 8.778380e-01 22 50280489 50280670 182 - 2.370 2.380 0.033
ENSG00000196576 E019 269.8588262 0.0001654671 5.519078e-01 6.813102e-01 22 50280744 50280973 230 - 2.372 2.401 0.097
ENSG00000196576 E020 128.5045780 0.0002678094 6.356279e-01 7.498789e-01 22 50281089 50281126 38 - 2.051 2.082 0.103
ENSG00000196576 E021 158.2637357 0.0010879548 3.614494e-01 5.058396e-01 22 50281127 50281189 63 - 2.172 2.158 -0.047
ENSG00000196576 E022 192.0965044 0.0035128848 2.235520e-01 3.546323e-01 22 50281360 50281499 140 - 2.265 2.238 -0.087
ENSG00000196576 E023 5.0694384 0.0032828625 1.061534e-01 1.998473e-01 22 50281500 50281565 66 - 0.562 0.815 1.064
ENSG00000196576 E024 79.7027143 0.0024766552 1.394819e-01 2.473178e-01 22 50281566 50281573 8 - 1.902 1.849 -0.180
ENSG00000196576 E025 215.8531461 0.0014457023 8.764106e-03 2.569336e-02 22 50281574 50281742 169 - 2.340 2.276 -0.214
ENSG00000196576 E026 0.7770552 0.0161438856 8.008630e-01 8.730842e-01 22 50281743 50281853 111 - 0.275 0.235 -0.293
ENSG00000196576 E027 245.3310742 0.0008556894 9.612719e-02 1.845554e-01 22 50281854 50282081 228 - 2.372 2.343 -0.097
ENSG00000196576 E028 165.4516229 0.0002407490 5.817989e-02 1.235123e-01 22 50282184 50282313 130 - 2.210 2.169 -0.137
ENSG00000196576 E029 1.1018559 0.0203446152 6.529954e-01 7.635967e-01 22 50282314 50282562 249 - 0.366 0.292 -0.462
ENSG00000196576 E030 182.6914822 0.0002158314 2.416794e-02 6.015377e-02 22 50282711 50282881 171 - 2.256 2.208 -0.161
ENSG00000196576 E031 168.6744248 0.0002793081 9.833632e-02 1.879890e-01 22 50283050 50283186 137 - 2.210 2.177 -0.112
ENSG00000196576 E032 80.7053427 0.0003338218 5.267242e-02 1.139113e-01 22 50283337 50283337 1 - 1.917 1.851 -0.220
ENSG00000196576 E033 152.6934924 0.0002510718 9.935327e-04 3.936212e-03 22 50283338 50283445 108 - 2.202 2.117 -0.284
ENSG00000196576 E034 140.6795546 0.0041796511 5.931964e-03 1.842918e-02 22 50283602 50283750 149 - 2.180 2.079 -0.338
ENSG00000196576 E035 156.3137225 0.0032866945 4.414534e-03 1.430439e-02 22 50283833 50283990 158 - 2.221 2.126 -0.317
ENSG00000196576 E036 97.2416731 0.0003288119 2.170427e-05 1.334353e-04 22 50284132 50284166 35 - 2.046 1.902 -0.482
ENSG00000196576 E037 113.1586101 0.0002687805 1.465315e-06 1.174328e-05 22 50284167 50284213 47 - 2.116 1.965 -0.507
ENSG00000196576 E038 4.7437760 0.0300854726 8.693882e-03 2.552150e-02 22 50284214 50284244 31 - 0.951 0.563 -1.575
ENSG00000196576 E039 129.7004452 0.0010701594 4.875829e-06 3.480711e-05 22 50284573 50284665 93 - 2.171 2.026 -0.485
ENSG00000196576 E040 4.9748138 0.0032233572 2.140225e-04 1.024146e-03 22 50284845 50284913 69 - 1.011 0.532 -1.945
ENSG00000196576 E041 121.7803382 0.0025738669 6.143194e-08 6.502093e-07 22 50285800 50285901 102 - 2.179 1.977 -0.674
ENSG00000196576 E042 123.0246623 0.0036842649 5.048754e-09 6.585000e-08 22 50285990 50286098 109 - 2.204 1.969 -0.788
ENSG00000196576 E043 122.0587718 0.0075761947 8.535207e-05 4.533262e-04 22 50286173 50286287 115 - 2.176 1.986 -0.638
ENSG00000196576 E044 115.6838869 0.0004300064 6.413748e-04 2.685236e-03 22 50287111 50287264 154 - 2.095 1.990 -0.351
ENSG00000196576 E045 108.4301928 0.0023507123 7.293136e-02 1.482153e-01 22 50287667 50287793 127 - 2.039 1.981 -0.196
ENSG00000196576 E046 90.5986045 0.0003274550 1.651352e-02 4.387403e-02 22 50287937 50287986 50 - 1.977 1.898 -0.265
ENSG00000196576 E047 93.5760447 0.0003242189 4.024403e-02 9.148091e-02 22 50287987 50288037 51 - 1.983 1.919 -0.216
ENSG00000196576 E048 124.1675548 0.0062131499 2.696644e-03 9.363644e-03 22 50288743 50288871 129 - 2.149 2.017 -0.442
ENSG00000196576 E049 67.4451819 0.0090657398 1.412693e-02 3.851275e-02 22 50288960 50288985 26 - 1.888 1.752 -0.457
ENSG00000196576 E050 98.6781836 0.0111539978 1.242232e-02 3.455251e-02 22 50288986 50289142 157 - 2.051 1.917 -0.451
ENSG00000196576 E051 227.9308629 0.0048921726 1.517025e-06 1.211669e-05 22 50289517 50290099 583 - 2.439 2.261 -0.594
ENSG00000196576 E052 195.4757169 0.0038729270 2.506271e-07 2.357057e-06 22 50290100 50290597 498 - 2.374 2.190 -0.612
ENSG00000196576 E053 18.5105041 0.0673762100 4.749245e-01 6.137105e-01 22 50294719 50294725 7 - 1.318 1.218 -0.354
ENSG00000196576 E054 38.4154827 0.0213198171 5.525958e-02 1.184370e-01 22 50294726 50294778 53 - 1.666 1.499 -0.570
ENSG00000196576 E055 17.0896418 0.0150213236 6.085914e-02 1.280851e-01 22 50295377 50295429 53 - 1.328 1.156 -0.605
ENSG00000196576 E056 2.0670323 0.0071765047 6.128827e-01 7.317227e-01 22 50301347 50301462 116 - 0.506 0.429 -0.388
ENSG00000196576 E057 39.3648997 0.0061509991 2.788403e-05 1.670634e-04 22 50307553 50307667 115 - 1.728 1.464 -0.899