ENSG00000196562

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000495544 ENSG00000196562 HEK293_OSMI2_2hA HEK293_TMG_2hB SULF2 protein_coding protein_coding 14.76384 17.78928 14.68242 0.2852048 0.08627407 -0.2767468 1.14134 3.273802 0.1416613 0.9366095 0.09664312 -4.43644230 0.06993333 0.1833000 0.009633333 -0.1736667 0.0008155677 0.0008155677 FALSE TRUE
ENST00000688720 ENSG00000196562 HEK293_OSMI2_2hA HEK293_TMG_2hB SULF2 protein_coding protein_coding 14.76384 17.78928 14.68242 0.2852048 0.08627407 -0.2767468 10.76797 11.559240 11.3720857 0.6962249 0.28721852 -0.02352913 0.73380833 0.6507333 0.774666667 0.1239333 0.1363483296 0.0008155677 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196562 E001 10.7038770 0.0015780961 3.893950e-02 8.907599e-02 20 47653406 47654260 855 - 1.165 0.967 -0.722
ENSG00000196562 E002 9.4744631 0.0020120833 3.590469e-01 5.033921e-01 20 47654261 47655047 787 - 1.057 0.967 -0.331
ENSG00000196562 E003 0.4782907 0.0215648040 1.222200e-01 2.231065e-01 20 47656175 47656347 173 - 0.000 0.275 12.033
ENSG00000196562 E004 0.9296148 0.1815942194 6.591423e-01 7.680445e-01 20 47656348 47656443 96 - 0.235 0.333 0.680
ENSG00000196562 E005 1.2889475 0.0104922166 8.589867e-02 1.688236e-01 20 47656912 47657251 340 - 0.499 0.202 -1.865
ENSG00000196562 E006 7.8128853 0.0376258371 2.688790e-01 4.073470e-01 20 47657252 47657405 154 - 1.014 0.862 -0.573
ENSG00000196562 E007 6.4882347 0.0025842271 8.575123e-01 9.120227e-01 20 47657406 47657434 29 - 0.873 0.857 -0.059
ENSG00000196562 E008 34.1691006 0.0024175826 1.589313e-02 4.249811e-02 20 47657435 47657667 233 - 1.440 1.604 0.561
ENSG00000196562 E009 418.5354069 0.0027704297 2.809296e-08 3.180427e-07 20 47657668 47658392 725 - 2.508 2.676 0.559
ENSG00000196562 E010 130.1686248 0.0011165741 6.037580e-01 7.244660e-01 20 47659399 47659452 54 - 2.096 2.122 0.087
ENSG00000196562 E011 8.0026783 0.0021167088 8.770214e-01 9.250278e-01 20 47659453 47659696 244 - 0.949 0.938 -0.040
ENSG00000196562 E012 109.7418553 0.0031503184 1.754670e-01 2.952796e-01 20 47659697 47659721 25 - 1.999 2.065 0.223
ENSG00000196562 E013 90.4257585 0.0011134140 1.090912e-01 2.042032e-01 20 47659722 47659730 9 - 1.912 1.985 0.243
ENSG00000196562 E014 5.2026006 0.0031598851 1.014424e-01 1.926631e-01 20 47661434 47661616 183 - 0.893 0.685 -0.829
ENSG00000196562 E015 174.9822489 0.0003442273 1.872053e-01 3.102278e-01 20 47661773 47661896 124 - 2.213 2.257 0.148
ENSG00000196562 E016 162.3403933 0.0020482811 2.480288e-01 3.836093e-01 20 47663070 47663212 143 - 2.177 2.226 0.164
ENSG00000196562 E017 153.7246367 0.0002143121 1.640759e-02 4.362989e-02 20 47663453 47663622 170 - 2.134 2.212 0.258
ENSG00000196562 E018 96.1350785 0.0003109198 3.867656e-02 8.858319e-02 20 47664130 47664189 60 - 1.927 2.011 0.281
ENSG00000196562 E019 112.8491407 0.0003174354 2.869026e-02 6.938690e-02 20 47665199 47665293 95 - 1.997 2.079 0.275
ENSG00000196562 E020 112.3404407 0.0028862949 4.598654e-01 5.999305e-01 20 47665857 47665953 97 - 2.023 2.060 0.126
ENSG00000196562 E021 159.6400693 0.0091231367 6.853801e-01 7.881465e-01 20 47666260 47666488 229 - 2.205 2.190 -0.052
ENSG00000196562 E022 0.1817044 0.0393443900 5.863956e-01   20 47672195 47672197 3 - 0.000 0.112 10.452
ENSG00000196562 E023 138.8197556 0.0010283737 5.397808e-01 6.710229e-01 20 47672198 47672393 196 - 2.142 2.129 -0.043
ENSG00000196562 E024 125.0861620 0.0002395278 5.040660e-01 6.399681e-01 20 47676494 47676623 130 - 2.100 2.086 -0.045
ENSG00000196562 E025 0.2924217 0.0290785164 1.499872e-01   20 47676624 47676692 69 - 0.235 0.000 -12.289
ENSG00000196562 E026 84.8156807 0.0003362109 4.482205e-01 5.895252e-01 20 47677078 47677134 57 - 1.936 1.915 -0.073
ENSG00000196562 E027 125.9302141 0.0003678861 2.466391e-01 3.820121e-01 20 47678676 47678804 129 - 2.111 2.081 -0.099
ENSG00000196562 E028 139.8484549 0.0046635479 6.235971e-02 1.306164e-01 20 47682994 47683169 176 - 2.179 2.106 -0.244
ENSG00000196562 E029 92.4247508 0.0076627875 5.537593e-02 1.186367e-01 20 47684431 47684513 83 - 2.014 1.916 -0.328
ENSG00000196562 E030 95.5780732 0.0030983717 1.800813e-03 6.601877e-03 20 47684514 47684581 68 - 2.047 1.917 -0.437
ENSG00000196562 E031 1.2878122 0.0125526994 8.816823e-02 1.723306e-01 20 47689548 47690125 578 - 0.133 0.443 2.306
ENSG00000196562 E032 126.9083010 0.0006041988 7.133142e-08 7.449226e-07 20 47690126 47690295 170 - 2.189 2.022 -0.559
ENSG00000196562 E033 99.7414056 0.0003304929 2.428969e-03 8.549043e-03 20 47702519 47702670 152 - 2.051 1.952 -0.334
ENSG00000196562 E034 1.4372236 0.0183882762 8.152490e-03 2.416851e-02 20 47706513 47706903 391 - 0.000 0.488 13.266
ENSG00000196562 E035 129.8160307 0.0002239863 3.404858e-04 1.542273e-03 20 47736703 47736942 240 - 2.166 2.064 -0.343
ENSG00000196562 E036 0.2987644 0.0290785164 1.498091e-01   20 47736943 47736943 1 - 0.235 0.000 -12.289
ENSG00000196562 E037 104.6553586 0.0003422305 1.658445e-04 8.172814e-04 20 47757189 47757463 275 - 2.082 1.959 -0.412
ENSG00000196562 E038 13.4359163 0.1036731333 7.417198e-02 1.502112e-01 20 47785343 47785489 147 - 1.293 1.008 -1.020
ENSG00000196562 E039 7.7751957 0.0034557763 4.694525e-02 1.037292e-01 20 47785835 47786047 213 - 1.043 0.821 -0.839
ENSG00000196562 E040 14.0371370 0.0012791983 9.276162e-01 9.584648e-01 20 47786048 47786616 569 - 1.165 1.181 0.055