ENSG00000196557

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562079 ENSG00000196557 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA1H protein_coding protein_coding 6.417272 9.066609 4.912209 1.123743 0.3385572 -0.8828474 1.4867241 4.008094 0.6869482 0.2810301 0.15031598 -2.52738782 0.20624167 0.4486333 0.1378000 -0.3108333 5.269131e-07 5.269131e-07 FALSE TRUE
ENST00000564231 ENSG00000196557 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA1H protein_coding protein_coding 6.417272 9.066609 4.912209 1.123743 0.3385572 -0.8828474 0.5127212 0.000000 0.0000000 0.0000000 0.00000000 0.00000000 0.07163333 0.0000000 0.0000000 0.0000000   5.269131e-07 FALSE TRUE
ENST00000565831 ENSG00000196557 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA1H protein_coding protein_coding 6.417272 9.066609 4.912209 1.123743 0.3385572 -0.8828474 1.7900928 1.173708 1.1975378 0.6222202 0.09969649 0.02875563 0.29730417 0.1227333 0.2457667 0.1230333 5.976056e-01 5.269131e-07 FALSE TRUE
ENST00000569107 ENSG00000196557 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA1H protein_coding protein_coding 6.417272 9.066609 4.912209 1.123743 0.3385572 -0.8828474 0.7700593 1.423275 0.3114948 0.4942680 0.15579475 -2.15644798 0.11099583 0.1561000 0.0607000 -0.0954000 5.126164e-01 5.269131e-07 FALSE TRUE
MSTRG.11761.7 ENSG00000196557 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA1H protein_coding   6.417272 9.066609 4.912209 1.123743 0.3385572 -0.8828474 1.4529074 2.043823 2.0585927 0.3234920 0.12025626 0.01033801 0.24432500 0.2264667 0.4197667 0.1933000 6.187671e-04 5.269131e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196557 E001 0.4439371 0.0215830877 3.258310e-02 7.696913e-02 16 1153106 1153240 135 + 0.345 0.000 -11.189
ENSG00000196557 E002 2.5206377 0.0224988308 8.053019e-04 3.277661e-03 16 1153241 1153470 230 + 0.797 0.252 -2.743
ENSG00000196557 E003 0.8200183 0.0156858657 3.319057e-01 4.755383e-01 16 1153720 1153737 18 + 0.345 0.183 -1.214
ENSG00000196557 E004 4.9933720 0.0085036542 2.103540e-01 3.389701e-01 16 1153738 1153938 201 + 0.849 0.693 -0.627
ENSG00000196557 E005 7.4426287 0.0030770424 1.971872e-01 3.227123e-01 16 1153939 1154035 97 + 0.996 0.862 -0.505
ENSG00000196557 E006 4.1296119 0.0333055039 4.718651e-01 6.109489e-01 16 1154036 1154036 1 + 0.768 0.666 -0.418
ENSG00000196557 E007 0.0000000       16 1194971 1194971 1 +      
ENSG00000196557 E008 7.1857806 0.0023695555 6.336674e-01 7.483220e-01 16 1194972 1195028 57 + 0.918 0.878 -0.155
ENSG00000196557 E009 8.0892179 0.0094319802 7.844659e-01 8.617276e-01 16 1195029 1195083 55 + 0.897 0.948 0.195
ENSG00000196557 E010 6.5112468 0.0649140650 7.060754e-01 8.043038e-01 16 1195432 1195470 39 + 0.768 0.875 0.421
ENSG00000196557 E011 15.2825729 0.0095849717 9.395959e-01 9.660774e-01 16 1195471 1195565 95 + 1.169 1.183 0.051
ENSG00000196557 E012 15.0355584 0.0093749890 4.504048e-01 5.914987e-01 16 1195926 1196023 98 + 1.214 1.159 -0.197
ENSG00000196557 E013 22.5279512 0.0008369392 4.547106e-03 1.467272e-02 16 1198615 1198774 160 + 1.461 1.274 -0.650
ENSG00000196557 E014 0.0000000       16 1198775 1198934 160 +      
ENSG00000196557 E015 46.8545744 0.0004694732 4.570901e-11 8.539034e-10 16 1200256 1200571 316 + 1.831 1.514 -1.076
ENSG00000196557 E016 29.5293786 0.0006898137 5.648648e-07 4.947156e-06 16 1200716 1200808 93 + 1.626 1.326 -1.034
ENSG00000196557 E017 41.7703502 0.0023908355 5.405533e-07 4.750044e-06 16 1201663 1201835 173 + 1.761 1.490 -0.922
ENSG00000196557 E018 63.9890439 0.0005104801 1.676935e-03 6.209012e-03 16 1201836 1202452 617 + 1.856 1.734 -0.413
ENSG00000196557 E019 67.8765260 0.0105004236 1.802081e-03 6.605758e-03 16 1204010 1204458 449 + 1.909 1.743 -0.561
ENSG00000196557 E020 35.4288381 0.0006842617 4.886061e-04 2.116496e-03 16 1205114 1205265 152 + 1.643 1.455 -0.641
ENSG00000196557 E021 34.9021124 0.0006652660 3.889480e-04 1.731972e-03 16 1206104 1206289 186 + 1.643 1.451 -0.656
ENSG00000196557 E022 36.6117096 0.0018922257 2.477410e-02 6.141156e-02 16 1207001 1207118 118 + 1.622 1.504 -0.403
ENSG00000196557 E023 50.8116604 0.0004989717 2.433980e-03 8.563820e-03 16 1207275 1207430 156 + 1.770 1.638 -0.449
ENSG00000196557 E024 46.2507707 0.0004654534 6.458589e-03 1.981667e-02 16 1207770 1207860 91 + 1.723 1.599 -0.419
ENSG00000196557 E025 55.8747660 0.0014767908 5.380640e-03 1.696168e-02 16 1208013 1208221 209 + 1.796 1.677 -0.403
ENSG00000196557 E026 56.5663762 0.0076676261 5.406849e-03 1.703274e-02 16 1209032 1209355 324 + 1.818 1.673 -0.488
ENSG00000196557 E027 27.9263857 0.0097317840 9.608208e-04 3.824681e-03 16 1209356 1209412 57 + 1.568 1.331 -0.818
ENSG00000196557 E028 1.2116283 0.1030130123 3.640130e-01 5.084207e-01 16 1209413 1209462 50 + 0.418 0.254 -1.021
ENSG00000196557 E029 19.7404301 0.0156610139 4.362449e-01 5.783435e-01 16 1210035 1210066 32 + 1.310 1.264 -0.161
ENSG00000196557 E030 34.3617112 0.0007166466 7.207846e-01 8.153339e-01 16 1210067 1210135 69 + 1.518 1.515 -0.013
ENSG00000196557 E031 51.6031653 0.0004287003 8.010831e-01 8.732337e-01 16 1210370 1210493 124 + 1.670 1.701 0.106
ENSG00000196557 E032 28.6868656 0.0006931528 9.671520e-01 9.834197e-01 16 1210583 1210607 25 + 1.430 1.451 0.072
ENSG00000196557 E033 31.7258935 0.0006865370 6.376276e-01 7.514752e-01 16 1210608 1210651 44 + 1.455 1.504 0.167
ENSG00000196557 E034 51.0365886 0.0004655219 3.453955e-01 4.895007e-01 16 1210787 1210971 185 + 1.702 1.673 -0.099
ENSG00000196557 E035 44.4264895 0.0073248352 2.559410e-01 3.929021e-01 16 1211168 1211294 127 + 1.654 1.607 -0.162
ENSG00000196557 E036 0.9189937 0.0217331225 1.716998e-01 2.904364e-01 16 1211295 1211448 154 + 0.418 0.183 -1.631
ENSG00000196557 E037 46.8411297 0.0241291318 8.590683e-01 9.130671e-01 16 1211481 1211606 126 + 1.631 1.661 0.103
ENSG00000196557 E038 38.7172559 0.0016327156 4.086801e-01 5.522941e-01 16 1211716 1211805 90 + 1.518 1.589 0.242
ENSG00000196557 E039 37.6403074 0.0016340165 6.555753e-01 7.654314e-01 16 1211946 1212007 62 + 1.524 1.571 0.162
ENSG00000196557 E040 49.2856401 0.0004871165 1.526455e-01 2.652683e-01 16 1212008 1212138 131 + 1.609 1.703 0.319
ENSG00000196557 E041 1.1489717 0.0118641428 3.194396e-01 4.625294e-01 16 1212139 1212171 33 + 0.418 0.252 -1.044
ENSG00000196557 E042 8.2949812 0.0022866127 4.853720e-01 6.232460e-01 16 1212511 1212528 18 + 0.874 0.972 0.372
ENSG00000196557 E043 56.1030478 0.0084960242 5.752393e-02 1.223736e-01 16 1213780 1213931 152 + 1.635 1.779 0.489
ENSG00000196557 E044 52.4102351 0.0115412037 3.527364e-02 8.217215e-02 16 1214972 1215081 110 + 1.587 1.757 0.579
ENSG00000196557 E045 50.8507588 0.0005081667 4.592430e-01 5.994712e-01 16 1215242 1215375 134 + 1.646 1.703 0.193
ENSG00000196557 E046 41.2026797 0.0005629234 6.760656e-01 7.811586e-01 16 1215523 1215593 71 + 1.568 1.611 0.144
ENSG00000196557 E047 51.6017450 0.0005929096 7.728302e-03 2.309682e-02 16 1216932 1217010 79 + 1.582 1.742 0.542
ENSG00000196557 E048 60.8389449 0.0009253146 2.110482e-01 3.397672e-01 16 1217919 1218040 122 + 1.709 1.789 0.271
ENSG00000196557 E049 134.4661018 0.0003516815 3.797990e-05 2.201168e-04 16 1218210 1218651 442 + 1.997 2.151 0.517
ENSG00000196557 E050 25.7840393 0.0007817157 4.213134e-02 9.496319e-02 16 1218970 1219002 33 + 1.284 1.451 0.580
ENSG00000196557 E051 65.7332393 0.0006347591 1.617318e-06 1.283657e-05 16 1219003 1219130 128 + 1.609 1.864 0.862
ENSG00000196557 E052 406.3531622 0.0041370700 4.594967e-11 8.581453e-10 16 1219981 1221771 1791 + 2.419 2.655 0.785