ENSG00000196550

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341209 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding protein_coding 13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 1.2139637 0.84440645 1.4296783 0.42562192 0.45443124 0.752752 0.09505000 0.07483333 0.08330000 0.008466667 0.9528671203 4.29224e-05 FALSE FALSE
ENST00000367128 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding protein_coding 13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 8.0898859 7.07089882 10.1475990 0.80530327 0.53500484 0.520555 0.60508333 0.68350000 0.60043333 -0.083066667 0.5979743585 4.29224e-05 FALSE TRUE
ENST00000431655 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding protein_coding 13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 0.5971507 0.37717761 0.0000000 0.23411957 0.00000000 -5.274924 0.05521667 0.03183333 0.00000000 -0.031833333 0.0672779111 4.29224e-05 FALSE FALSE
ENST00000468509 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding protein_coding 13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 0.8637710 1.93922420 0.8420967 0.10848450 0.07448009 -1.193811 0.07811667 0.19596667 0.04963333 -0.146333333 0.0000429224 4.29224e-05   FALSE
MSTRG.2944.5 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding   13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 0.5865818 0.05782106 2.6168818 0.05782106 0.54327274 5.275474 0.03441250 0.00470000 0.15743333 0.152733333 0.0002210410 4.29224e-05   FALSE
MSTRG.2944.6 ENSG00000196550 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM72A protein_coding   13.53613 10.37722 17.08225 1.269872 0.9997293 0.7185328 1.8635569 0.00000000 1.6800893 0.00000000 1.68008934 7.400956 0.10643750 0.00000000 0.08816667 0.088166667 0.9154897385 4.29224e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196550 E001 0.0000000       1 206186179 206186255 77 -      
ENSG00000196550 E002 79.3433454 0.0003644577 0.04058500 0.09209354 1 206186256 206187122 867 - 1.868 1.943 0.250
ENSG00000196550 E003 42.6662365 0.0005163784 0.08393265 0.16570085 1 206187123 206187165 43 - 1.597 1.685 0.299
ENSG00000196550 E004 34.0090836 0.0006306271 0.10817011 0.20283139 1 206187166 206187280 115 - 1.496 1.588 0.315
ENSG00000196550 E005 60.8995138 0.0004584167 0.99284409 0.99961913 1 206187281 206187373 93 - 1.794 1.794 0.000
ENSG00000196550 E006 83.1007830 0.0004495376 0.11102751 0.20705295 1 206195752 206195839 88 - 1.953 1.896 -0.192
ENSG00000196550 E007 52.8209591 0.0005247988 0.77161981 0.85259637 1 206195840 206195876 37 - 1.737 1.724 -0.045
ENSG00000196550 E008 45.3427084 0.0005934046 0.04916285 0.10766725 1 206199807 206199884 78 - 1.711 1.612 -0.336
ENSG00000196550 E009 0.1472490 0.0440533049 0.63817177   1 206201281 206201873 593 - 0.108 0.000 -9.153
ENSG00000196550 E010 13.2408236 0.0069867744 0.10136651 0.19255185 1 206201874 206201889 16 - 1.220 1.060 -0.574
ENSG00000196550 E011 22.1681459 0.0009504852 0.91409035 0.94957426 1 206201890 206201993 104 - 1.364 1.356 -0.029
ENSG00000196550 E012 12.8476620 0.0024464738 0.90316601 0.94239736 1 206201994 206202005 12 - 1.138 1.148 0.035
ENSG00000196550 E013 15.7850796 0.0012031437 0.58640241 0.70997305 1 206202006 206202515 510 - 1.249 1.202 -0.163
ENSG00000196550 E014 0.2965864 0.0797427797 0.14942948   1 206202516 206202609 94 - 0.000 0.241 10.661
ENSG00000196550 E015 0.5932745 0.0213484419 0.79172143 0.86677945 1 206202610 206202851 242 - 0.195 0.242 0.394
ENSG00000196550 E016 2.8554663 0.1639913971 0.65160776 0.76243529 1 206203180 206203558 379 - 0.642 0.513 -0.586
ENSG00000196550 E017 2.0814299 0.2332588476 0.68356187 0.78673381 1 206203844 206204093 250 - 0.473 0.510 0.182
ENSG00000196550 E018 0.2955422 0.0288368850 0.84404888   1 206204252 206204414 163 - 0.108 0.138 0.396