ENSG00000196511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360057 ENSG00000196511 HEK293_OSMI2_2hA HEK293_TMG_2hB TPK1 protein_coding protein_coding 1.986757 2.856394 1.327037 0.3894613 0.09000594 -1.100197 0.3611327 0.4357582 0.3090898 0.07368638 0.04600643 -0.4822990 0.199166667 0.1631333 0.23340000 0.07026667 0.5904415435 0.0001938596 FALSE TRUE
ENST00000378099 ENSG00000196511 HEK293_OSMI2_2hA HEK293_TMG_2hB TPK1 protein_coding protein_coding 1.986757 2.856394 1.327037 0.3894613 0.09000594 -1.100197 0.1374908 0.1289295 0.2038221 0.12892952 0.06145848 0.6220580 0.076970833 0.0357000 0.15523333 0.11953333 0.2058787990 0.0001938596 FALSE TRUE
ENST00000546806 ENSG00000196511 HEK293_OSMI2_2hA HEK293_TMG_2hB TPK1 protein_coding processed_transcript 1.986757 2.856394 1.327037 0.3894613 0.09000594 -1.100197 0.1550602 0.3026515 0.2018593 0.09275294 0.06291220 -0.5614488 0.071204167 0.1017000 0.15886667 0.05716667 0.7716811901 0.0001938596   FALSE
ENST00000547966 ENSG00000196511 HEK293_OSMI2_2hA HEK293_TMG_2hB TPK1 protein_coding processed_transcript 1.986757 2.856394 1.327037 0.3894613 0.09000594 -1.100197 0.0108240 0.0000000 0.0865920 0.00000000 0.08659200 3.2719037 0.007258333 0.0000000 0.05806667 0.05806667 0.6408838821 0.0001938596 FALSE TRUE
ENST00000548460 ENSG00000196511 HEK293_OSMI2_2hA HEK293_TMG_2hB TPK1 protein_coding processed_transcript 1.986757 2.856394 1.327037 0.3894613 0.09000594 -1.100197 1.2202582 1.9826394 0.4270343 0.24843539 0.10124254 -2.1888622 0.582391667 0.6970667 0.31486667 -0.38220000 0.0001938596 0.0001938596   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196511 E001 0.0000000       7 144451941 144451942 2 -      
ENSG00000196511 E002 0.0000000       7 144451943 144451949 7 -      
ENSG00000196511 E003 10.5886741 0.002157741 2.962163e-01 4.374219e-01 7 144451950 144452581 632 - 1.111 0.999 -0.408
ENSG00000196511 E004 14.2216987 0.001713604 1.905013e-01 3.143884e-01 7 144452582 144453427 846 - 1.234 1.113 -0.433
ENSG00000196511 E005 6.2907389 0.009896648 4.711314e-02 1.040274e-01 7 144453428 144453663 236 - 0.997 0.739 -0.993
ENSG00000196511 E006 0.1482932 0.042292268 7.638432e-01   7 144531064 144531109 46 - 0.000 0.096 9.888
ENSG00000196511 E007 0.0000000       7 144531110 144531169 60 -      
ENSG00000196511 E008 4.6237342 0.056120379 1.853324e-01 3.079066e-01 7 144548491 144548602 112 - 0.867 0.630 -0.962
ENSG00000196511 E009 0.0000000       7 144591137 144591422 286 -      
ENSG00000196511 E010 0.5870335 0.068960919 1.364031e-02 3.740433e-02 7 144591423 144591423 1 - 0.431 0.000 -13.813
ENSG00000196511 E011 3.2304016 0.008697572 1.222094e-01 2.230957e-01 7 144591424 144591569 146 - 0.754 0.511 -1.059
ENSG00000196511 E012 0.0000000       7 144606929 144607050 122 -      
ENSG00000196511 E013 0.0000000       7 144619181 144623165 3985 -      
ENSG00000196511 E014 4.5976979 0.004196054 3.629377e-02 8.414198e-02 7 144623166 144623261 96 - 0.892 0.601 -1.184
ENSG00000196511 E015 0.0000000       7 144643544 144643573 30 -      
ENSG00000196511 E016 0.0000000       7 144646086 144646114 29 -      
ENSG00000196511 E017 0.1472490 0.048425574 3.011516e-01   7 144646115 144646163 49 - 0.154 0.000 -12.074
ENSG00000196511 E018 2.4055402 0.008830182 5.295445e-03 1.673600e-02 7 144648807 144648879 73 - 0.754 0.301 -2.228
ENSG00000196511 E019 0.0000000       7 144666620 144666702 83 -      
ENSG00000196511 E020 0.0000000       7 144666703 144666718 16 -      
ENSG00000196511 E021 0.0000000       7 144667726 144667846 121 -      
ENSG00000196511 E022 2.8377422 0.005560441 1.008416e-01 1.917475e-01 7 144681740 144681806 67 - 0.357 0.628 1.346
ENSG00000196511 E023 2.9515801 0.005761784 2.164956e-01 3.461894e-01 7 144681807 144681864 58 - 0.431 0.627 0.931
ENSG00000196511 E024 5.5033225 0.032623680 7.164359e-01 8.120876e-01 7 144682909 144682978 70 - 0.815 0.761 -0.212
ENSG00000196511 E025 0.0000000       7 144709285 144709334 50 -      
ENSG00000196511 E026 0.0000000       7 144709424 144709482 59 -      
ENSG00000196511 E027 0.0000000       7 144724110 144724159 50 -      
ENSG00000196511 E028 0.0000000       7 144736154 144736253 100 -      
ENSG00000196511 E029 0.0000000       7 144738836 144738891 56 -      
ENSG00000196511 E030 0.0000000       7 144738892 144738922 31 -      
ENSG00000196511 E031 0.0000000       7 144738923 144738924 2 -      
ENSG00000196511 E032 0.0000000       7 144739273 144739477 205 -      
ENSG00000196511 E033 5.9442634 0.003127134 9.431472e-01 9.683466e-01 7 144765880 144765951 72 - 0.815 0.795 -0.076
ENSG00000196511 E034 14.1155842 0.001408228 1.054057e-05 6.971127e-05 7 144835131 144835559 429 - 0.815 1.248 1.596
ENSG00000196511 E035 14.0114912 0.001441449 2.316942e-02 5.810127e-02 7 144835560 144835618 59 - 0.997 1.196 0.721
ENSG00000196511 E036 9.3546405 0.024671822 3.252242e-01 4.686544e-01 7 144835967 144835999 33 - 0.892 1.014 0.454
ENSG00000196511 E037 4.9164147 0.003675940 1.531779e-01 2.659959e-01 7 144836000 144836053 54 - 0.599 0.795 0.816
ENSG00000196511 E038 0.1515154 0.042915611 3.021152e-01   7 144836331 144836395 65 - 0.154 0.000 -12.082