ENSG00000196505

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369442 ENSG00000196505 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP2 protein_coding protein_coding 8.189836 6.20391 9.441682 0.2068496 0.1803172 0.6050698 1.0010916 0.7402878 1.6633675 0.18983047 0.13937861 1.1572383 0.1166125 0.11803333 0.17600000 0.05796667 4.371016e-01 1.768912e-07 FALSE  
ENST00000369443 ENSG00000196505 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP2 protein_coding protein_coding 8.189836 6.20391 9.441682 0.2068496 0.1803172 0.6050698 0.7740598 0.4325419 0.9869216 0.01981768 0.02512252 1.1716660 0.0950875 0.06986667 0.10470000 0.03483333 2.277676e-01 1.768912e-07 FALSE  
ENST00000491626 ENSG00000196505 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP2 protein_coding processed_transcript 8.189836 6.20391 9.441682 0.2068496 0.1803172 0.6050698 1.1831373 1.5062942 0.8373821 0.11109991 0.42231510 -0.8394652 0.1580792 0.24296667 0.08723333 -0.15573333 4.376941e-01 1.768912e-07 FALSE  
ENST00000493555 ENSG00000196505 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP2 protein_coding processed_transcript 8.189836 6.20391 9.441682 0.2068496 0.1803172 0.6050698 0.5636374 0.0000000 0.7653283 0.00000000 0.16176886 6.2767355 0.0585500 0.00000000 0.08046667 0.08046667 1.768912e-07 1.768912e-07 FALSE  
MSTRG.1908.1 ENSG00000196505 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP2 protein_coding   8.189836 6.20391 9.441682 0.2068496 0.1803172 0.6050698 4.0538408 3.1753864 4.5716801 0.13417551 0.07452283 0.5244084 0.4972750 0.51356667 0.48463333 -0.02893333 8.325250e-01 1.768912e-07 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196505 E001 0.2966881 0.0290785164 3.074332e-01   1 117834047 117834085 39 - 0.193 0.000 -9.657
ENSG00000196505 E002 114.1402733 0.0003615861 4.288756e-06 3.097095e-05 1 117863485 117870183 6699 - 2.127 1.972 -0.520
ENSG00000196505 E003 32.1580693 0.0007602252 1.312560e-03 5.019286e-03 1 117870184 117870376 193 - 1.422 1.610 0.645
ENSG00000196505 E004 20.2767959 0.0010218575 1.100443e-03 4.304606e-03 1 117870377 117870395 19 - 1.207 1.445 0.833
ENSG00000196505 E005 57.4764265 0.0004143544 4.617755e-04 2.013487e-03 1 117870396 117870616 221 - 1.691 1.842 0.512
ENSG00000196505 E006 18.3603304 0.0149199625 5.640393e-01 6.914292e-01 1 117877222 117877775 554 - 1.319 1.262 -0.198
ENSG00000196505 E007 9.1378503 0.0019510058 8.824380e-01 9.287255e-01 1 117877776 117877841 66 - 1.010 1.020 0.037
ENSG00000196505 E008 11.1488649 0.0015300359 4.525879e-02 1.006638e-01 1 117877842 117878008 167 - 1.175 0.970 -0.746
ENSG00000196505 E009 59.6258016 0.0003987406 2.122797e-01 3.412192e-01 1 117878009 117878152 144 - 1.761 1.810 0.165
ENSG00000196505 E010 39.5667036 0.0005704765 4.180441e-02 9.437001e-02 1 117881823 117881877 55 - 1.559 1.663 0.356
ENSG00000196505 E011 4.1684077 0.0038176974 1.682093e-01 2.858799e-01 1 117882904 117883487 584 - 0.610 0.800 0.787
ENSG00000196505 E012 53.7705605 0.0010806598 3.899878e-01 5.340186e-01 1 117883488 117883627 140 - 1.726 1.762 0.119
ENSG00000196505 E013 39.6249812 0.0005615814 7.443271e-02 1.506297e-01 1 117886577 117886653 77 - 1.566 1.656 0.309
ENSG00000196505 E014 40.0867457 0.0005998764 2.988190e-02 7.173369e-02 1 117887698 117887774 77 - 1.559 1.671 0.380
ENSG00000196505 E015 2.9486697 0.0053995115 1.650622e-04 8.138705e-04 1 117896616 117896832 217 - 0.800 0.139 -3.809
ENSG00000196505 E016 63.6132385 0.0010153681 3.161697e-01 4.589277e-01 1 117896833 117896989 157 - 1.837 1.786 -0.169
ENSG00000196505 E017 65.8544248 0.0102656082 6.934850e-01 7.945152e-01 1 117899057 117899216 160 - 1.840 1.815 -0.084
ENSG00000196505 E018 44.5778960 0.0157528208 5.292566e-01 6.620582e-01 1 117906506 117906582 77 - 1.685 1.633 -0.177
ENSG00000196505 E019 42.0691045 0.0094477821 4.556714e-01 5.961834e-01 1 117911994 117912082 89 - 1.665 1.601 -0.218
ENSG00000196505 E020 50.0788453 0.0006133726 4.154544e-01 5.588330e-01 1 117912530 117912683 154 - 1.731 1.684 -0.158
ENSG00000196505 E021 1.0360537 0.3392831409 2.817326e-01 4.216516e-01 1 117913420 117913499 80 - 0.428 0.137 -2.172
ENSG00000196505 E022 52.0249786 0.0078259429 6.218588e-01 7.387706e-01 1 117918597 117918736 140 - 1.742 1.699 -0.145
ENSG00000196505 E023 66.4832582 0.0097161300 5.153522e-01 6.500345e-01 1 117920182 117920424 243 - 1.851 1.798 -0.179
ENSG00000196505 E024 0.0000000       1 117924249 117924386 138 -      
ENSG00000196505 E025 29.3873749 0.0112022756 2.805148e-01 4.203695e-01 1 117929448 117929621 174 - 1.524 1.428 -0.331