ENSG00000196504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000410080 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding protein_coding 51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 2.758459 0.5963247 4.3391295 0.18438160 0.4643985 2.8425641 0.05180417 0.04553333 0.04746667 0.001933333 9.719913e-01 2.181775e-35 FALSE TRUE
ENST00000450303 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding retained_intron 51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 1.782955 3.5867601 0.9264818 0.51406463 0.1785709 -1.9413751 0.10114583 0.28203333 0.01000000 -0.272033333 2.181775e-35 2.181775e-35   FALSE
ENST00000489741 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding retained_intron 51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 1.004472 1.3070600 1.1187611 0.06256882 0.1195350 -0.2225809 0.03803333 0.10620000 0.01223333 -0.093966667 4.549970e-14 2.181775e-35   FALSE
ENST00000696381 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding protein_coding 51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 8.951747 2.8865114 14.7871428 0.55024133 1.1007469 2.3529304 0.17071667 0.22593333 0.16133333 -0.064600000 4.001510e-01 2.181775e-35 FALSE TRUE
MSTRG.19358.5 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding   51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 7.398383 2.0778114 13.2579177 0.11342607 0.1118929 2.6678786 0.14293333 0.16783333 0.14386667 -0.023966667 6.418989e-01 2.181775e-35 FALSE TRUE
MSTRG.19358.6 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding   51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 20.033311 0.7225398 39.7420873 0.39874674 4.2892448 5.7619797 0.30315833 0.05610000 0.42796667 0.371866667 5.644990e-02 2.181775e-35 FALSE TRUE
MSTRG.19358.7 ENSG00000196504 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF40A protein_coding   51.77362 12.65267 92.35693 1.202911 3.311113 2.866795 4.779940 0.0000000 9.1879564 0.00000000 1.4729478 9.8451695 0.06664167 0.00000000 0.10060000 0.100600000 1.573670e-12 2.181775e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196504 E001 1.0351233 0.0120588563 4.585082e-01 5.988156e-01 2 152650919 152651045 127 - 0.247 0.000 -10.606
ENSG00000196504 E002 0.8105550 0.0153787590 5.491485e-01 6.789126e-01 2 152651593 152651731 139 - 0.158 0.294 1.146
ENSG00000196504 E003 14.3515241 0.0013486692 1.072143e-02 3.050223e-02 2 152651732 152651882 151 - 0.959 1.288 1.183
ENSG00000196504 E004 14.6628723 0.0011610997 2.634400e-03 9.173393e-03 2 152651883 152651901 19 - 0.959 1.329 1.327
ENSG00000196504 E005 1303.3796081 0.0054351803 1.396876e-10 2.405763e-09 2 152651902 152656305 4404 - 2.887 3.153 0.886
ENSG00000196504 E006 367.8828022 0.0021783849 6.087666e-04 2.565126e-03 2 152656306 152656398 93 - 2.356 2.519 0.544
ENSG00000196504 E007 2.1423665 0.0066892483 6.170560e-01 7.349391e-01 2 152657885 152657888 4 - 0.384 0.294 -0.555
ENSG00000196504 E008 344.8849113 0.0009477638 4.491671e-02 1.000463e-01 2 152657889 152657954 66 - 2.337 2.446 0.361
ENSG00000196504 E009 329.2500025 0.0001640865 1.762226e-02 4.631830e-02 2 152657955 152658020 66 - 2.316 2.430 0.381
ENSG00000196504 E010 284.6596475 0.0003140228 4.922137e-03 1.571284e-02 2 152658948 152659009 62 - 2.251 2.384 0.445
ENSG00000196504 E011 3.1860226 0.0049664219 3.021838e-01 4.440328e-01 2 152659010 152659092 83 - 0.504 0.294 -1.177
ENSG00000196504 E012 310.9606973 0.0001753460 2.003870e-02 5.156997e-02 2 152659093 152659189 97 - 2.291 2.406 0.384
ENSG00000196504 E013 267.0877668 0.0007424872 9.111228e-02 1.768721e-01 2 152659270 152659356 87 - 2.227 2.331 0.346
ENSG00000196504 E014 0.8825757 0.0139151381 6.784055e-01 7.828846e-01 2 152659357 152659377 21 - 0.190 0.294 0.822
ENSG00000196504 E015 316.5990481 0.0001619537 6.112331e-01 7.303769e-01 2 152662603 152662698 96 - 2.306 2.368 0.206
ENSG00000196504 E016 359.3287517 0.0012947200 5.649741e-01 6.921696e-01 2 152663035 152663130 96 - 2.366 2.394 0.093
ENSG00000196504 E017 258.7190319 0.0001710889 2.849197e-01 4.252147e-01 2 152663131 152663172 42 - 2.226 2.236 0.033
ENSG00000196504 E018 360.9055405 0.0001535122 3.685136e-02 8.518656e-02 2 152663655 152663771 117 - 2.374 2.359 -0.049
ENSG00000196504 E019 0.5827671 0.1114558197 1.000000e+00 1.000000e+00 2 152663772 152663855 84 - 0.157 0.000 -9.770
ENSG00000196504 E020 333.1780462 0.0001598691 1.351610e-01 2.413165e-01 2 152663876 152663967 92 - 2.337 2.338 0.004
ENSG00000196504 E021 52.2063035 0.0032971681 9.709148e-02 1.860297e-01 2 152663968 152663979 12 - 1.555 1.463 -0.316
ENSG00000196504 E022 314.3689073 0.0001508209 7.550898e-01 8.405236e-01 2 152664138 152664252 115 - 2.307 2.344 0.123
ENSG00000196504 E023 404.2965745 0.0001252723 3.239361e-09 4.367881e-08 2 152669137 152669270 134 - 2.434 2.306 -0.428
ENSG00000196504 E024 465.8132389 0.0001510713 2.362051e-12 5.453127e-11 2 152670231 152670381 151 - 2.498 2.348 -0.500
ENSG00000196504 E025 387.7769972 0.0005072991 1.401270e-09 2.022139e-08 2 152671273 152671381 109 - 2.418 2.270 -0.496
ENSG00000196504 E026 339.5363325 0.0002303460 8.185077e-12 1.727923e-10 2 152672459 152672547 89 - 2.363 2.179 -0.615
ENSG00000196504 E027 280.6166061 0.0004877979 1.415647e-08 1.697509e-07 2 152672548 152672623 76 - 2.280 2.113 -0.558
ENSG00000196504 E028 254.6875813 0.0002014982 4.987200e-07 4.411290e-06 2 152672978 152673042 65 - 2.236 2.093 -0.479
ENSG00000196504 E029 271.7354711 0.0004883760 2.271663e-08 2.621268e-07 2 152673598 152673706 109 - 2.266 2.100 -0.557
ENSG00000196504 E030 456.0119710 0.0001473282 1.736809e-14 5.532759e-13 2 152676405 152676779 375 - 2.490 2.316 -0.579
ENSG00000196504 E031 163.9012604 0.0002598038 1.692989e-05 1.067398e-04 2 152677451 152677475 25 - 2.046 1.889 -0.528
ENSG00000196504 E032 163.3284586 0.0002242272 1.958709e-05 1.217786e-04 2 152679056 152679109 54 - 2.045 1.889 -0.523
ENSG00000196504 E033 1.1845624 0.0106395017 3.776562e-01 5.219695e-01 2 152679129 152679351 223 - 0.273 0.000 -10.772
ENSG00000196504 E034 292.6670408 0.0001884316 5.964550e-11 1.091228e-09 2 152679352 152679472 121 - 2.300 2.110 -0.637
ENSG00000196504 E035 299.3391267 0.0023129857 5.866332e-11 1.075543e-09 2 152681226 152681336 111 - 2.315 2.073 -0.809
ENSG00000196504 E036 156.5250113 0.0016783733 1.285661e-07 1.278823e-06 2 152690962 152690978 17 - 2.035 1.792 -0.815
ENSG00000196504 E037 195.6661872 0.0023712858 1.881746e-10 3.167121e-09 2 152693038 152693068 31 - 2.135 1.843 -0.978
ENSG00000196504 E038 1.3275450 0.0095443891 3.142776e-01 4.569866e-01 2 152693069 152693111 43 - 0.298 0.000 -10.942
ENSG00000196504 E039 7.8595352 0.0085889420 7.607503e-01 8.447495e-01 2 152693158 152693476 319 - 0.781 0.767 -0.055
ENSG00000196504 E040 9.7092727 0.0264772323 6.421711e-14 1.875114e-12 2 152694063 152694436 374 - 0.560 1.541 3.681
ENSG00000196504 E041 17.4079066 0.0026060433 1.999363e-41 7.590646e-39 2 152694437 152694541 105 - 0.643 1.843 4.341
ENSG00000196504 E042 354.4299753 0.0090612289 4.365321e-02 9.774685e-02 2 152694542 152694622 81 - 2.343 2.498 0.517
ENSG00000196504 E043 13.1109458 0.0014042010 3.368615e-20 2.198655e-18 2 152714550 152714629 80 - 0.703 1.630 3.361
ENSG00000196504 E044 370.5202673 0.0030723808 1.080477e-04 5.591181e-04 2 152715995 152716126 132 - 2.356 2.545 0.628
ENSG00000196504 E045 1.2190178 0.0105168425 9.158467e-01 9.507820e-01 2 152716127 152716130 4 - 0.247 0.294 0.338
ENSG00000196504 E046 74.5588400 0.0005726532 1.458027e-04 7.290982e-04 2 152717230 152717355 126 - 1.654 1.910 0.865
ENSG00000196504 E047 221.9799434 0.0046112750 5.425895e-04 2.319365e-03 2 152717356 152717431 76 - 2.130 2.338 0.696
ENSG00000196504 E048 78.2414006 0.0045859339 5.148366e-09 6.703385e-08 2 152717432 152717625 194 - 1.642 2.033 1.318
ENSG00000196504 E049 24.1215384 0.0019911712 4.233903e-01 5.664470e-01 2 152717626 152717830 205 - 1.204 1.329 0.439
ENSG00000196504 E050 31.2097969 0.0006796295 3.388234e-03 1.140328e-02 2 152717831 152717992 162 - 1.282 1.566 0.979
ENSG00000196504 E051 13.9139399 0.0013885735 9.086798e-04 3.644315e-03 2 152717993 152718412 420 - 0.921 1.329 1.472