ENSG00000196459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359680 ENSG00000196459 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC2 protein_coding protein_coding 13.29633 8.253402 15.55239 1.143434 0.6124917 0.9132559 4.388313 5.2297886 3.421620 0.99320590 0.50826720 -0.6106188 0.3969208 0.62556667 0.2221333 -0.4034333 1.064037e-05 2.596865e-14 FALSE TRUE
ENST00000380579 ENSG00000196459 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC2 protein_coding protein_coding 13.29633 8.253402 15.55239 1.143434 0.6124917 0.9132559 3.761084 2.2843526 5.342749 0.38959065 0.40124178 1.2221928 0.2792917 0.28530000 0.3425000 0.0572000 6.512031e-01 2.596865e-14 FALSE TRUE
ENST00000519382 ENSG00000196459 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC2 protein_coding retained_intron 13.29633 8.253402 15.55239 1.143434 0.6124917 0.9132559 1.483085 0.2918559 2.189628 0.03612789 0.09675224 2.8653281 0.1052917 0.03773333 0.1409000 0.1031667 1.995512e-07 2.596865e-14 FALSE TRUE
ENST00000519885 ENSG00000196459 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC2 protein_coding protein_coding 13.29633 8.253402 15.55239 1.143434 0.6124917 0.9132559 2.531923 0.0000000 3.202883 0.00000000 0.68179368 8.3277247 0.1359833 0.00000000 0.2045667 0.2045667 2.596865e-14 2.596865e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196459 E001 1.6167419 0.0248914096 9.230974e-01 9.554976e-01 X 13711654 13712031 378 - 0.389 0.440 0.274
ENSG00000196459 E002 0.1451727 0.0431451449 6.760143e-01   X 13712244 13712244 1 - 0.094 0.000 -10.962
ENSG00000196459 E003 2.2423068 0.0074882672 9.233789e-02 1.787732e-01 X 13712245 13712263 19 - 0.344 0.693 1.703
ENSG00000196459 E004 443.9925686 0.0106244343 1.593453e-08 1.891802e-07 X 13712264 13714199 1936 - 2.501 2.789 0.961
ENSG00000196459 E005 12.1802783 0.0147979844 1.950787e-01 3.200829e-01 X 13714200 13714200 1 - 1.008 1.253 0.880
ENSG00000196459 E006 44.9096812 0.0020865698 4.247011e-01 5.676442e-01 X 13714201 13714343 143 - 1.627 1.688 0.208
ENSG00000196459 E007 61.7988594 0.0083846190 8.052411e-01 8.761128e-01 X 13714344 13714505 162 - 1.736 1.852 0.392
ENSG00000196459 E008 8.7277314 0.0325368959 2.206393e-01 3.511880e-01 X 13715497 13715536 40 - 1.008 0.928 -0.296
ENSG00000196459 E009 18.4751102 0.0010757504 5.992946e-05 3.311108e-04 X 13715537 13715799 263 - 1.357 1.123 -0.827
ENSG00000196459 E010 10.6417096 0.0015906504 5.663392e-06 3.981837e-05 X 13715800 13715836 37 - 1.177 0.765 -1.541
ENSG00000196459 E011 14.0800812 0.0013254062 4.099800e-06 2.973564e-05 X 13715837 13716003 167 - 1.276 0.927 -1.265
ENSG00000196459 E012 41.0540736 0.0007505021 8.834548e-01 9.294445e-01 X 13716004 13716089 86 - 1.566 1.680 0.389
ENSG00000196459 E013 17.6038677 0.0066818614 3.093421e-07 2.854134e-06 X 13716090 13716533 444 - 1.384 0.989 -1.408
ENSG00000196459 E014 99.2182529 0.0002773356 3.306126e-04 1.503157e-03 X 13716534 13716678 145 - 1.999 1.982 -0.054
ENSG00000196459 E015 0.2955422 0.0289687813 8.062556e-01   X 13716679 13716718 40 - 0.094 0.158 0.855
ENSG00000196459 E016 95.4035934 0.0003304625 1.862256e-06 1.459113e-05 X 13719871 13719982 112 - 1.997 1.934 -0.212
ENSG00000196459 E017 0.4741261 0.0213301250 7.884518e-01 8.645826e-01 X 13719983 13720427 445 - 0.171 0.158 -0.142
ENSG00000196459 E018 4.7724989 0.0035644863 7.073303e-02 1.445572e-01 X 13720428 13720497 70 - 0.817 0.653 -0.667
ENSG00000196459 E019 0.6245948 0.0891079767 4.833561e-02 1.062190e-01 X 13720498 13722240 1743 - 0.000 0.368 13.129
ENSG00000196459 E020 0.2214452 0.0383941588 3.488369e-01   X 13722307 13722414 108 - 0.000 0.158 11.777
ENSG00000196459 E021 22.5552149 0.0404605835 2.395811e-02 5.971636e-02 X 13734044 13734049 6 - 1.418 1.247 -0.595
ENSG00000196459 E022 38.3496290 0.0029193832 3.618199e-07 3.291510e-06 X 13734050 13734185 136 - 1.658 1.437 -0.756
ENSG00000196459 E023 51.0861037 0.0061863315 1.979259e-03 7.162376e-03 X 13734525 13734635 111 - 1.739 1.656 -0.284