ENSG00000196419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360079 ENSG00000196419 HEK293_OSMI2_2hA HEK293_TMG_2hB XRCC6 protein_coding protein_coding 500.5796 482.8675 561.0241 61.42439 19.90693 0.2164315 422.4416 440.09336 420.9739 60.934240 7.906128 -0.06407743 0.84833333 0.9087333 0.7512667 -0.1574667 3.708847e-08 3.708847e-08 FALSE TRUE
ENST00000464116 ENSG00000196419 HEK293_OSMI2_2hA HEK293_TMG_2hB XRCC6 protein_coding retained_intron 500.5796 482.8675 561.0241 61.42439 19.90693 0.2164315 52.0117 17.28301 108.8831 2.252841 10.777090 2.65465146 0.09847917 0.0379000 0.1932000 0.1553000 1.820059e-07 3.708847e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196419 E001 0.0000000       22 41621163 41621169 7 +      
ENSG00000196419 E002 0.0000000       22 41621170 41621172 3 +      
ENSG00000196419 E003 0.1482932 0.0411597534 5.751699e-01   22 41621173 41621174 2 + 0.000 0.112 10.053
ENSG00000196419 E004 0.1482932 0.0411597534 5.751699e-01   22 41621175 41621185 11 + 0.000 0.112 10.096
ENSG00000196419 E005 3.2354080 0.0174314971 2.042730e-01 3.315051e-01 22 41621186 41621206 21 + 0.499 0.708 0.930
ENSG00000196419 E006 4.0114190 0.0814251922 5.154182e-01 6.500918e-01 22 41621207 41621210 4 + 0.627 0.751 0.517
ENSG00000196419 E007 28.3960161 0.0006878001 1.094428e-06 9.008738e-06 22 41621211 41621279 69 + 1.627 1.317 -1.067
ENSG00000196419 E008 57.4442373 0.0004139945 2.563069e-07 2.405220e-06 22 41621280 41621284 5 + 1.888 1.652 -0.796
ENSG00000196419 E009 85.6203352 0.0006755716 4.873712e-07 4.318770e-06 22 41621285 41621294 10 + 2.038 1.841 -0.663
ENSG00000196419 E010 1329.4628067 0.0018672493 5.069710e-39 1.653083e-36 22 41621295 41621345 51 + 3.276 2.963 -1.043
ENSG00000196419 E011 0.8126314 0.0150573113 1.133580e-01 2.104126e-01 22 41621346 41621349 4 + 0.387 0.112 -2.285
ENSG00000196419 E012 98.7596098 0.0054006163 1.262277e-03 4.850796e-03 22 41621350 41621410 61 + 2.086 1.919 -0.560
ENSG00000196419 E013 53.1669180 0.0144071110 2.331475e-01 3.661595e-01 22 41621411 41621445 35 + 1.783 1.688 -0.322
ENSG00000196419 E014 42.3498504 0.0225567378 1.979485e-01 3.236589e-01 22 41621446 41621460 15 + 1.702 1.578 -0.420
ENSG00000196419 E015 85.4125089 0.0047273693 8.602886e-03 2.529553e-02 22 41621461 41621591 131 + 2.007 1.869 -0.466
ENSG00000196419 E016 71.5293391 0.0039664000 4.392138e-06 3.166321e-05 22 41621592 41621982 391 + 1.980 1.739 -0.812
ENSG00000196419 E017 34.3270295 0.0255976304 1.485541e-02 4.016544e-02 22 41621983 41621989 7 + 1.673 1.417 -0.878
ENSG00000196419 E018 2863.6831616 0.0015820919 2.859472e-17 1.315809e-15 22 41621990 41622086 97 + 3.549 3.367 -0.602
ENSG00000196419 E019 0.4375944 0.0255813670 5.996865e-02 1.265568e-01 22 41626479 41626597 119 + 0.318 0.000 -12.533
ENSG00000196419 E020 0.1451727 0.0435092198 4.158108e-01   22 41626830 41626917 88 + 0.133 0.000 -10.948
ENSG00000196419 E021 3564.2575345 0.0019972205 4.873972e-10 7.645601e-09 22 41628118 41628230 113 + 3.627 3.478 -0.494
ENSG00000196419 E022 0.0000000       22 41628231 41628318 88 +      
ENSG00000196419 E023 3436.4207711 0.0016111388 5.090364e-05 2.863284e-04 22 41636113 41636235 123 + 3.581 3.489 -0.306
ENSG00000196419 E024 2035.7222429 0.0006301178 3.588414e-05 2.091736e-04 22 41636236 41636251 16 + 3.341 3.276 -0.219
ENSG00000196419 E025 6085.8307137 0.0002802776 4.209559e-24 4.210603e-22 22 41636516 41636770 255 + 3.833 3.738 -0.316
ENSG00000196419 E026 3140.0253471 0.0002638337 3.756648e-26 4.532298e-24 22 41637608 41637671 64 + 3.554 3.446 -0.359
ENSG00000196419 E027 4166.4191295 0.0006174309 3.585472e-07 3.264873e-06 22 41637672 41637791 120 + 3.656 3.582 -0.244
ENSG00000196419 E028 5014.0911210 0.0004507979 1.706139e-02 4.507236e-02 22 41646896 41647082 187 + 3.714 3.681 -0.110
ENSG00000196419 E029 4826.3226847 0.0001353211 1.103467e-02 3.124539e-02 22 41650723 41650891 169 + 3.670 3.687 0.057
ENSG00000196419 E030 4593.4886132 0.0006120101 1.999892e-04 9.637117e-04 22 41653529 41653690 162 + 3.630 3.673 0.143
ENSG00000196419 E031 2950.5308176 0.0001601077 3.738432e-28 5.365415e-26 22 41656903 41656952 50 + 3.407 3.505 0.326
ENSG00000196419 E032 3502.9552260 0.0002277861 5.454198e-22 4.339695e-20 22 41656953 41657032 80 + 3.486 3.575 0.294
ENSG00000196419 E033 1756.6168236 0.0001587288 2.644659e-27 3.509904e-25 22 41658252 41658254 3 + 3.172 3.286 0.381
ENSG00000196419 E034 1948.3344608 0.0003509497 4.405455e-20 2.823411e-18 22 41658255 41658260 6 + 3.217 3.328 0.368
ENSG00000196419 E035 4507.8193534 0.0007922072 7.307719e-15 2.458578e-13 22 41658261 41658352 92 + 3.582 3.687 0.349
ENSG00000196419 E036 5087.8737678 0.0009609815 4.511392e-14 1.346785e-12 22 41661331 41661444 114 + 3.631 3.741 0.365
ENSG00000196419 E037 10.1928983 0.0353938475 4.083309e-03 1.337594e-02 22 41661445 41661699 255 + 1.234 0.853 -1.398
ENSG00000196419 E038 6645.2912675 0.0017540744 4.516808e-12 9.944170e-11 22 41663622 41664362 741 + 3.732 3.864 0.438