ENSG00000196418

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340684 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding protein_coding 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 1.0688326 0.2482548 2.18447951 0.12772036 0.22836062 3.0870116 0.27336250 0.1561000 0.42113333 0.265033333 2.690104e-01 1.551333e-07 FALSE TRUE
ENST00000472531 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding protein_coding 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 0.8472700 0.7619759 1.08158186 0.13306946 0.09269899 0.4997927 0.30514167 0.4737000 0.21473333 -0.258966667 3.142675e-02 1.551333e-07   FALSE
ENST00000476312 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding processed_transcript 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 0.2157407 0.0000000 0.48869514 0.00000000 0.48869514 5.6400862 0.06969583 0.0000000 0.07676667 0.076766667 1.000000e+00 1.551333e-07   FALSE
ENST00000491356 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding protein_coding 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 0.1571274 0.2585489 0.04380346 0.02021222 0.02192096 -2.3194143 0.07233750 0.1624333 0.00820000 -0.154233333 1.551333e-07 1.551333e-07   FALSE
ENST00000491848 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding processed_transcript 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 0.1987819 0.0000000 0.36451926 0.00000000 0.07162578 5.2269680 0.06479167 0.0000000 0.07410000 0.074100000 8.580386e-03 1.551333e-07 FALSE FALSE
ENST00000543802 ENSG00000196418 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF124 protein_coding protein_coding 3.179661 1.599072 5.216892 0.09269147 0.5758127 1.699725 0.6919086 0.3302920 1.05381312 0.03759014 0.03838378 1.6443998 0.21466667 0.2077667 0.20510000 -0.002666667 9.497313e-01 1.551333e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196418 E001 31.4897324 0.0009026301 6.307563e-07 5.470125e-06 1 247121975 247123502 1528 - 1.389 1.653 0.903
ENSG00000196418 E002 14.4765526 0.0026708180 9.472115e-03 2.746852e-02 1 247123503 247123871 369 - 1.095 1.300 0.731
ENSG00000196418 E003 2.4282630 0.0065813383 1.213064e-04 6.198888e-04 1 247138145 247138715 571 - 0.214 0.813 3.115
ENSG00000196418 E004 1.3587756 0.0104743896 4.869285e-02 1.068430e-01 1 247138716 247138757 42 - 0.214 0.544 1.978
ENSG00000196418 E005 1.3735519 0.0126060378 3.257387e-01 4.691793e-01 1 247149858 247149950 93 - 0.314 0.477 0.915
ENSG00000196418 E006 17.4974960 0.0093532202 4.193728e-01 5.626216e-01 1 247154989 247155900 912 - 1.233 1.287 0.192
ENSG00000196418 E007 39.9916852 0.0196687034 8.568620e-05 4.548459e-04 1 247155901 247156916 1016 - 1.681 1.315 -1.256
ENSG00000196418 E008 23.7816857 0.0009112761 8.930205e-08 9.148824e-07 1 247156917 247157217 301 - 1.480 1.000 -1.698
ENSG00000196418 E009 5.3144795 0.0032622298 5.049677e-01 6.408224e-01 1 247157218 247157403 186 - 0.813 0.699 -0.460
ENSG00000196418 E010 18.1390971 0.0014892637 7.994941e-01 8.720956e-01 1 247159006 247159066 61 - 1.274 1.231 -0.153
ENSG00000196418 E011 28.1380774 0.0007525534 2.644888e-01 4.024561e-01 1 247159687 247159813 127 - 1.429 1.477 0.167
ENSG00000196418 E012 0.7384352 0.0164823036 1.397370e-01 2.476613e-01 1 247159814 247159867 54 - 0.314 0.000 -10.002
ENSG00000196418 E013 18.5111357 0.0010592776 6.894741e-01 7.913509e-01 1 247171848 247172020 173 - 1.269 1.279 0.034