ENSG00000196417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396408 ENSG00000196417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF765 protein_coding protein_coding 2.257104 0.5040143 3.627228 0.04933856 0.2786691 2.822959 1.91250321 0.38486782 3.05050274 0.010593406 0.31555094 2.9543270 0.81002500 0.7740000 0.840266667 0.06626667 0.66939365 0.03419874 FALSE TRUE
ENST00000505866 ENSG00000196417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF765 protein_coding protein_coding 2.257104 0.5040143 3.627228 0.04933856 0.2786691 2.822959 0.14403882 0.00000000 0.40824926 0.000000000 0.21835100 5.3862911 0.04119583 0.0000000 0.114633333 0.11463333 0.22295955 0.03419874 FALSE TRUE
ENST00000507045 ENSG00000196417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF765 protein_coding nonsense_mediated_decay 2.257104 0.5040143 3.627228 0.04933856 0.2786691 2.822959 0.04887495 0.06197955 0.03164362 0.040193950 0.03164362 -0.7894916 0.03523750 0.1103333 0.007766667 -0.10256667 0.19136022 0.03419874 TRUE FALSE
ENST00000594030 ENSG00000196417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF765 protein_coding protein_coding 2.257104 0.5040143 3.627228 0.04933856 0.2786691 2.822959 0.05835571 0.04919217 0.04070933 0.007006016 0.01187487 -0.2231552 0.06313333 0.0974000 0.011800000 -0.08560000 0.03419874 0.03419874 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196417 E001 0.0000000       19 53389793 53390209 417 +      
ENSG00000196417 E002 0.5870335 0.078721160 0.8348453442 0.8966180783 19 53395144 53395148 5 + 0.204 0.000 -11.435
ENSG00000196417 E003 0.7342825 0.015842533 0.5766632127 0.7020436317 19 53395149 53395154 6 + 0.243 0.000 -13.577
ENSG00000196417 E004 1.3285892 0.010053763 0.8638689949 0.9162372954 19 53395155 53395160 6 + 0.343 0.232 -0.771
ENSG00000196417 E005 2.1328015 0.007655538 0.9133988868 0.9491199759 19 53395161 53395172 12 + 0.448 0.382 -0.355
ENSG00000196417 E006 3.0990246 0.005544465 0.8259553145 0.8904575156 19 53395173 53395193 21 + 0.551 0.494 -0.272
ENSG00000196417 E007 4.4223152 0.004635158 0.5480644827 0.6779706560 19 53397943 53398030 88 + 0.663 0.655 -0.033
ENSG00000196417 E008 3.0726346 0.122363988 0.4040047143 0.5477369940 19 53402065 53402191 127 + 0.531 0.583 0.242
ENSG00000196417 E009 183.8854528 0.029250229 0.0001024847 0.0005335228 19 53407698 53412009 4312 + 2.213 1.982 -0.773
ENSG00000196417 E010 0.3686942 0.030560106 0.1739227960 0.2932880432 19 53423062 53423319 258 + 0.061 0.232 2.233
ENSG00000196417 E011 0.5159433 0.328355083 0.3708479075 0.5152585865 19 53423320 53423374 55 + 0.114 0.236 1.263
ENSG00000196417 E012 0.6611159 0.031853118 0.5083363776 0.6437654284 19 53423375 53423502 128 + 0.162 0.232 0.649
ENSG00000196417 E013 0.8877725 0.014788485 0.2129124459 0.3419637068 19 53423503 53425070 1568 + 0.204 0.382 1.227
ENSG00000196417 E014 0.8847512 0.104646395 0.1547846519 0.2681249755 19 53425071 53425147 77 + 0.162 0.386 1.666
ENSG00000196417 E015 0.4407149 0.021841597 0.3405615697 0.4845103535 19 53425148 53425329 182 + 0.114 0.231 1.228
ENSG00000196417 E016 1.6166533 0.022838578 0.0007543573 0.0030952254 19 53425330 53425451 122 + 0.204 0.718 2.813
ENSG00000196417 E017 2.2830798 0.006451638 0.0001212523 0.0006197211 19 53425452 53426017 566 + 0.279 0.822 2.644
ENSG00000196417 E018 0.4439371 0.021817314 1.0000000000 1.0000000000 19 53426018 53426042 25 + 0.162 0.000 -12.994
ENSG00000196417 E019 1.3726095 0.010146811 0.8656971577 0.9174982486 19 53426043 53426489 447 + 0.343 0.232 -0.770
ENSG00000196417 E020 0.6172225 0.424127538 0.4572012267 0.5975701350 19 53426490 53426584 95 + 0.161 0.233 0.660
ENSG00000196417 E021 0.3289534 0.037426445 0.1739504339   19 53426585 53426595 11 + 0.061 0.232 2.231
ENSG00000196417 E022 1.2168397 0.014790479 0.0882376203 0.1724259650 19 53426596 53426864 269 + 0.243 0.493 1.491
ENSG00000196417 E023 0.7384472 0.027537575 0.1421354549 0.2509425141 19 53426865 53426868 4 + 0.162 0.381 1.640
ENSG00000196417 E024 1.3284874 0.042219152 0.1459837215 0.2562180664 19 53426869 53426936 68 + 0.279 0.491 1.220
ENSG00000196417 E025 0.0000000       19 53426937 53427086 150 +      
ENSG00000196417 E026 2.3000066 0.206411228 0.0426863270 0.0959709076 19 53427087 53430413 3327 + 0.343 0.721 1.821