ENSG00000196396

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371621 ENSG00000196396 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN1 protein_coding protein_coding 43.1031 47.17712 40.33205 3.332404 0.3326913 -0.2261087 29.291186 37.469559 23.356731 1.9371244 0.3536304 -0.6816481 0.67421250 0.79630000 0.5790333 -0.21726667 1.707612e-11 1.707612e-11 FALSE TRUE
MSTRG.20847.2 ENSG00000196396 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN1 protein_coding   43.1031 47.17712 40.33205 3.332404 0.3326913 -0.2261087 3.783804 3.129715 4.878632 0.7366134 0.5673824 0.6387972 0.08902083 0.06590000 0.1207667 0.05486667 1.504328e-01 1.707612e-11 FALSE TRUE
MSTRG.20847.4 ENSG00000196396 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN1 protein_coding   43.1031 47.17712 40.33205 3.332404 0.3326913 -0.2261087 4.485372 3.029184 5.491124 0.7804369 0.5015110 0.8560425 0.10579583 0.06256667 0.1360667 0.07350000 9.492349e-03 1.707612e-11 FALSE TRUE
MSTRG.20847.5 ENSG00000196396 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN1 protein_coding   43.1031 47.17712 40.33205 3.332404 0.3326913 -0.2261087 5.197924 2.990557 6.407688 0.5869702 0.6977455 1.0968231 0.12325000 0.06320000 0.1591333 0.09593333 3.918339e-03 1.707612e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196396 E001 0.1482932 0.0414149368 6.766811e-01   20 50510321 50510357 37 + 0.000 0.113 8.246
ENSG00000196396 E002 11.9633257 0.0026377802 5.291790e-03 1.672588e-02 20 50510358 50510382 25 + 1.204 1.009 -0.704
ENSG00000196396 E003 13.3554238 0.0062790448 3.933612e-02 8.979419e-02 20 50510383 50510383 1 + 1.214 1.090 -0.442
ENSG00000196396 E004 207.8182270 0.0078592622 1.505043e-02 4.060292e-02 20 50510384 50510590 207 + 2.330 2.297 -0.110
ENSG00000196396 E005 0.0000000       20 50548510 50548552 43 +      
ENSG00000196396 E006 236.0223514 0.0018186749 3.895438e-06 2.840457e-05 20 50561363 50561453 91 + 2.398 2.340 -0.194
ENSG00000196396 E007 268.9130719 0.0010581543 7.986189e-10 1.206218e-08 20 50564969 50565069 101 + 2.466 2.388 -0.262
ENSG00000196396 E008 309.7115060 0.0003173240 5.539478e-09 7.173189e-08 20 50568380 50568478 99 + 2.508 2.465 -0.142
ENSG00000196396 E009 369.6528721 0.0019655231 6.857599e-06 4.732965e-05 20 50574517 50574654 138 + 2.583 2.542 -0.135
ENSG00000196396 E010 389.7622770 0.0022036957 1.028662e-03 4.057400e-03 20 50578420 50578629 210 + 2.588 2.580 -0.027
ENSG00000196396 E011 283.6218591 0.0006464946 5.214602e-05 2.924830e-04 20 50579168 50579329 162 + 2.455 2.440 -0.048
ENSG00000196396 E012 334.3969657 0.0002826935 2.236168e-06 1.721325e-05 20 50579703 50579926 224 + 2.528 2.513 -0.049
ENSG00000196396 E013 370.4749884 0.0005415327 3.082134e-05 1.828519e-04 20 50581265 50581460 196 + 2.567 2.562 -0.016
ENSG00000196396 E014 122.3910395 0.0002509657 1.314582e-06 1.064062e-05 20 50581461 50581734 274 + 2.125 2.050 -0.252
ENSG00000196396 E015 86.0615102 0.0040299364 5.753657e-02 1.223950e-01 20 50581936 50582086 151 + 1.938 1.926 -0.039
ENSG00000196396 E016 2481.7752414 0.0027053805 2.258300e-21 1.690285e-19 20 50582692 50585241 2550 + 3.235 3.468 0.773