ENSG00000196372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357700 ENSG00000196372 HEK293_OSMI2_2hA HEK293_TMG_2hB ASB13 protein_coding protein_coding 34.96391 56.51538 22.71221 1.407941 0.539636 -1.314795 29.133995 45.727163 20.8274045 1.9771759 0.1347440 -1.134191 0.85671250 0.8095333 0.9177667 0.1082333 0.03491849 0.03491849 FALSE TRUE
ENST00000493897 ENSG00000196372 HEK293_OSMI2_2hA HEK293_TMG_2hB ASB13 protein_coding processed_transcript 34.96391 56.51538 22.71221 1.407941 0.539636 -1.314795 2.927528 5.870431 0.7217585 0.8857604 0.3734447 -3.006483 0.06269583 0.1039000 0.0311000 -0.0728000 0.37621769 0.03491849 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196372 E001 4.419751 0.0740377585 6.584778e-01 7.676032e-01 10 5638867 5638867 1 - 0.611 0.719 0.461
ENSG00000196372 E002 786.022507 0.0054678864 1.309436e-06 1.060440e-05 10 5638868 5639371 504 - 2.686 2.873 0.623
ENSG00000196372 E003 1715.862532 0.0003917264 3.539554e-04 1.595427e-03 10 5639372 5640695 1324 - 3.129 3.185 0.188
ENSG00000196372 E004 304.495066 0.0002665781 4.907123e-03 1.567161e-02 10 5640696 5640830 135 - 2.452 2.410 -0.139
ENSG00000196372 E005 329.725920 0.0017957930 1.096090e-05 7.215865e-05 10 5641770 5641961 192 - 2.528 2.427 -0.335
ENSG00000196372 E006 11.338216 0.0015955415 3.498253e-01 4.940205e-01 10 5642473 5642553 81 - 1.090 1.012 -0.286
ENSG00000196372 E007 103.726061 0.0012282349 1.737869e-03 6.401348e-03 10 5648970 5648971 2 - 2.031 1.926 -0.352
ENSG00000196372 E008 255.310892 0.0016581072 1.672010e-04 8.231098e-04 10 5648972 5649104 133 - 2.410 2.319 -0.302
ENSG00000196372 E009 218.578903 0.0047472159 1.266291e-03 4.864741e-03 10 5651213 5651363 151 - 2.357 2.247 -0.366
ENSG00000196372 E010 1.324333 0.0102929707 1.855858e-01 3.082337e-01 10 5651364 5651568 205 - 0.485 0.261 -1.318
ENSG00000196372 E011 194.872337 0.0088745475 4.511882e-02 1.004150e-01 10 5652863 5653050 188 - 2.285 2.206 -0.264
ENSG00000196372 E012 99.203175 0.0053231766 1.616027e-02 4.308047e-02 10 5666509 5666600 92 - 2.009 1.907 -0.343