ENSG00000196369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000621582 ENSG00000196369 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2B protein_coding nonsense_mediated_decay 5.076068 2.061518 8.057064 0.1597446 0.5968782 1.961355 0.2042979 0.0000000 0.6165975 0.00000000 0.6165975 5.969467 0.02373333 0.0000000 0.06786667 0.06786667 1.00000000 0.04985435   FALSE
ENST00000641863 ENSG00000196369 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2B protein_coding protein_coding 5.076068 2.061518 8.057064 0.1597446 0.5968782 1.961355 3.0174057 1.6749221 4.6756114 0.11227169 0.2373469 1.475555 0.65910417 0.8138667 0.58943333 -0.22443333 0.04985435 0.04985435 FALSE TRUE
MSTRG.1989.4 ENSG00000196369 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2B protein_coding   5.076068 2.061518 8.057064 0.1597446 0.5968782 1.961355 0.3879257 0.3276631 0.9883878 0.07680866 0.5558733 1.564016 0.08598750 0.1553000 0.13440000 -0.02090000 0.82624345 0.04985435 FALSE TRUE
MSTRG.1989.9 ENSG00000196369 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2B protein_coding   5.076068 2.061518 8.057064 0.1597446 0.5968782 1.961355 1.0233982 0.0000000 1.1481880 0.00000000 0.5814866 6.855726 0.13335833 0.0000000 0.13510000 0.13510000 0.34984102 0.04985435 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196369 E001 0.0000000       1 144874725 144874736 12 -      
ENSG00000196369 E002 0.0000000       1 144874737 144874783 47 -      
ENSG00000196369 E003 0.0000000       1 144874784 144874907 124 -      
ENSG00000196369 E004 0.0000000       1 144878724 144878823 100 -      
ENSG00000196369 E005 1.7851075 0.105947743 0.11375408 0.21099887 1 144887265 144887287 23 - 0.303 0.615 1.627
ENSG00000196369 E006 11.7679165 0.003354114 0.01332955 0.03668864 1 144887288 144889280 1993 - 0.986 1.224 0.859
ENSG00000196369 E007 6.3514731 0.002709381 0.17442388 0.29393941 1 144889281 144891983 2703 - 0.781 0.948 0.641
ENSG00000196369 E008 13.8494891 0.017884910 0.09407073 0.18149192 1 144891984 144892183 200 - 1.197 0.996 -0.727
ENSG00000196369 E009 13.8462669 0.015267645 0.13794153 0.24521104 1 144892184 144892381 198 - 1.192 1.018 -0.625
ENSG00000196369 E010 2.4617669 0.076060464 0.77019254 0.85161038 1 144893408 144893509 102 - 0.507 0.557 0.234
ENSG00000196369 E011 4.0097355 0.047499412 0.23588574 0.36941874 1 144897116 144897235 120 - 0.605 0.796 0.796
ENSG00000196369 E012 9.6156046 0.022465370 0.58493692 0.70873681 1 144897236 144897337 102 - 0.976 1.040 0.236
ENSG00000196369 E013 3.4311236 0.004650251 0.66569951 0.77334970 1 144897338 144897340 3 - 0.605 0.669 0.278
ENSG00000196369 E014 38.8890678 0.007007085 0.91544237 0.95047971 1 144905091 144905219 129 - 1.567 1.572 0.015
ENSG00000196369 E015 37.8731657 0.008037755 0.54216772 0.67297001 1 144905859 144906039 181 - 1.570 1.527 -0.146
ENSG00000196369 E016 5.8669388 0.003005002 0.26669766 0.40493593 1 144906040 144906074 35 - 0.751 0.894 0.556
ENSG00000196369 E017 6.4019248 0.002750787 0.49553160 0.63231721 1 144914692 144914754 63 - 0.810 0.893 0.324
ENSG00000196369 E018 10.9112220 0.001917232 0.83277043 0.89523211 1 144955439 144955601 163 - 1.045 1.019 -0.095
ENSG00000196369 E019 8.6108771 0.002691869 0.08685993 0.17037024 1 144960338 144960398 61 - 1.012 0.796 -0.823
ENSG00000196369 E020 14.1122328 0.003764674 0.08569421 0.16850218 1 144995008 144995200 193 - 1.197 1.019 -0.641
ENSG00000196369 E021 4.5874451 0.037315664 0.73625839 0.82679485 1 145092835 145092907 73 - 0.736 0.671 -0.268
ENSG00000196369 E022 2.7000382 0.006950342 0.70621245 0.80440249 1 145092908 145092977 70 - 0.559 0.491 -0.321
ENSG00000196369 E023 0.9672673 0.013610873 0.75995556 0.84418860 1 145092978 145092986 9 - 0.257 0.312 0.378
ENSG00000196369 E024 1.0017226 0.013156684 0.25046800 0.38650472 1 145092987 145093042 56 - 0.206 0.411 1.378
ENSG00000196369 E025 0.3332198 0.029173678 0.48080296   1 145093043 145093052 10 - 0.080 0.183 1.378
ENSG00000196369 E026 1.4392284 0.034410210 0.09172648 0.17782207 1 145093053 145093443 391 - 0.257 0.558 1.696
ENSG00000196369 E027 0.1472490 0.042974151 1.00000000   1 145094873 145094894 22 - 0.080 0.000 -8.265
ENSG00000196369 E028 0.1472490 0.042974151 1.00000000   1 145094895 145095222 328 - 0.080 0.000 -8.265
ENSG00000196369 E029 0.6287620 0.018165671 0.34824849 0.49247296 1 145095223 145095390 168 - 0.147 0.311 1.377
ENSG00000196369 E030 0.0000000       1 145095391 145095528 138 -