ENSG00000196352

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367063 ENSG00000196352 HEK293_OSMI2_2hA HEK293_TMG_2hB CD55 protein_coding protein_coding 22.83196 16.64212 26.88838 1.163149 0.6561935 0.6918134 1.642588 2.536868 1.558339 0.15093921 0.3677445 -0.6994864 0.0957000 0.1529333 0.05736667 -0.09556667 3.173868e-03 1.34276e-06 FALSE TRUE
ENST00000367064 ENSG00000196352 HEK293_OSMI2_2hA HEK293_TMG_2hB CD55 protein_coding protein_coding 22.83196 16.64212 26.88838 1.163149 0.6561935 0.6918134 7.048664 2.933333 9.350720 0.08119227 0.3598228 1.6691687 0.2882042 0.1772333 0.34873333 0.17150000 1.342760e-06 1.34276e-06 FALSE TRUE
MSTRG.2958.13 ENSG00000196352 HEK293_OSMI2_2hA HEK293_TMG_2hB CD55 protein_coding   22.83196 16.64212 26.88838 1.163149 0.6561935 0.6918134 11.062907 9.522935 12.796813 0.80181921 0.8293243 0.4259192 0.4868208 0.5713333 0.47496667 -0.09636667 5.079947e-02 1.34276e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196352 E001 2.3229380 0.0338390475 1.114408e-01 2.076604e-01 1 207321519 207321519 1 + 0.632 0.335 -1.503
ENSG00000196352 E002 2.4744534 0.0405674566 8.486273e-02 1.671865e-01 1 207321520 207321529 10 + 0.659 0.335 -1.618
ENSG00000196352 E003 2.1756890 0.0263097284 1.466745e-01 2.571612e-01 1 207321530 207321531 2 + 0.604 0.335 -1.377
ENSG00000196352 E004 2.1767332 0.0075998724 3.497676e-01 4.939611e-01 1 207321532 207321537 6 + 0.573 0.406 -0.826
ENSG00000196352 E005 4.6803303 0.0034965550 2.282085e-01 3.602850e-01 1 207321538 207321581 44 + 0.830 0.651 -0.727
ENSG00000196352 E006 6.0756506 0.0263648176 8.932896e-01 9.358312e-01 1 207321582 207321642 61 + 0.864 0.832 -0.120
ENSG00000196352 E007 4.6622431 0.0115600199 6.659856e-01 7.735350e-01 1 207321643 207321660 18 + 0.731 0.780 0.197
ENSG00000196352 E008 8.7718604 0.1139106830 8.139159e-01 8.820557e-01 1 207321661 207321677 17 + 1.024 0.944 -0.295
ENSG00000196352 E009 18.7376631 0.0420924965 7.028512e-02 1.438373e-01 1 207321678 207321700 23 + 1.390 1.133 -0.902
ENSG00000196352 E010 38.6449829 0.0246757046 1.189694e-01 2.184673e-01 1 207321701 207321747 47 + 1.667 1.493 -0.593
ENSG00000196352 E011 51.1021938 0.0168403918 1.876897e-01 3.108260e-01 1 207321748 207321790 43 + 1.769 1.641 -0.433
ENSG00000196352 E012 65.7526376 0.0116267686 9.843127e-02 1.881268e-01 1 207321791 207321865 75 + 1.881 1.745 -0.457
ENSG00000196352 E013 0.0000000       1 207322236 207322289 54 +      
ENSG00000196352 E014 100.6793153 0.0071605177 1.535705e-02 4.130015e-02 1 207322382 207322463 82 + 2.069 1.917 -0.510
ENSG00000196352 E015 131.6599945 0.0004569763 5.171524e-02 1.122102e-01 1 207322464 207322567 104 + 2.158 2.083 -0.250
ENSG00000196352 E016 156.5284430 0.0003330426 7.399030e-01 8.294961e-01 1 207324559 207324657 99 + 2.201 2.198 -0.010
ENSG00000196352 E017 162.8244244 0.0003212592 5.785549e-01 7.036200e-01 1 207324658 207324750 93 + 2.215 2.218 0.009
ENSG00000196352 E018 96.0337354 0.0003302782 8.171838e-01 8.843780e-01 1 207325622 207325639 18 + 1.990 1.986 -0.014
ENSG00000196352 E019 155.1056546 0.0002758363 1.356150e-01 2.419694e-01 1 207325640 207325721 82 + 2.180 2.210 0.099
ENSG00000196352 E020 146.7098172 0.0002649943 1.944754e-01 3.193692e-01 1 207326752 207326831 80 + 2.162 2.187 0.085
ENSG00000196352 E021 92.5911604 0.0003537353 1.639367e-01 2.802753e-01 1 207326832 207326837 6 + 1.957 1.996 0.130
ENSG00000196352 E022 1.3671946 0.0102126290 2.222513e-01 3.530982e-01 1 207326838 207327546 709 + 0.261 0.467 1.233
ENSG00000196352 E023 233.4192212 0.0002441529 6.241953e-03 1.924861e-02 1 207331108 207331296 189 + 2.349 2.400 0.169
ENSG00000196352 E024 0.2924217 0.0290785164 3.287371e-01   1 207331297 207332223 927 + 0.190 0.000 -11.831
ENSG00000196352 E025 0.1482932 0.0407473355 3.411830e-01   1 207336578 207336692 115 + 0.000 0.142 11.545
ENSG00000196352 E026 157.9543830 0.0002622553 2.614465e-03 9.109348e-03 1 207336693 207336753 61 + 2.171 2.242 0.239
ENSG00000196352 E027 191.2401192 0.0002510761 9.119825e-02 1.770052e-01 1 207336754 207336818 65 + 2.271 2.302 0.101
ENSG00000196352 E028 13.6361723 0.0012712070 4.854653e-05 2.744143e-04 1 207336819 207337328 510 + 0.965 1.324 1.289
ENSG00000196352 E029 224.4724479 0.0023146656 3.050479e-01 4.470866e-01 1 207337329 207337409 81 + 2.346 2.365 0.062
ENSG00000196352 E030 9.8675990 0.0017148281 1.400301e-04 7.037146e-04 1 207337410 207339396 1987 + 1.191 0.751 -1.648
ENSG00000196352 E031 136.1665266 0.0006417567 9.490318e-01 9.720457e-01 1 207339397 207339417 21 + 2.145 2.135 -0.034
ENSG00000196352 E032 4.4192184 0.0037345686 8.526585e-02 1.678341e-01 1 207339418 207340390 973 + 0.830 0.569 -1.088
ENSG00000196352 E033 26.4923363 0.0008131483 4.833478e-07 4.285995e-06 1 207340391 207340508 118 + 1.262 1.589 1.132
ENSG00000196352 E034 15.2547976 0.0011974547 6.950463e-08 7.278048e-07 1 207340509 207340582 74 + 0.938 1.404 1.665
ENSG00000196352 E035 11.3778561 0.0015451708 1.093422e-05 7.199303e-05 1 207340583 207340766 184 + 0.847 1.273 1.559
ENSG00000196352 E036 0.3030308 0.3958434283 4.361053e-01   1 207347447 207347561 115 + 0.191 0.000 -11.839
ENSG00000196352 E037 0.2987644 0.0294081725 3.279906e-01   1 207354007 207354099 93 + 0.190 0.000 -11.832
ENSG00000196352 E038 0.3289534 0.0286390835 7.835799e-01   1 207358516 207358621 106 + 0.105 0.142 0.496
ENSG00000196352 E039 156.0331008 0.0003425650 6.360137e-01 7.501518e-01 1 207359546 207359642 97 + 2.210 2.184 -0.087
ENSG00000196352 E040 222.6321849 0.0042750415 5.536545e-05 3.084955e-04 1 207359643 207360966 1324 + 2.419 2.250 -0.565
ENSG00000196352 E041 1.0361675 0.0117499190 1.306532e-01 2.350693e-01 1 207362651 207362784 134 + 0.422 0.142 -2.090
ENSG00000196352 E042 0.5869198 0.1393451413 1.123446e-01 2.089684e-01 1 207365913 207365940 28 + 0.321 0.000 -12.830
ENSG00000196352 E043 1.0297230 0.1141488067 9.785561e-01 9.907200e-01 1 207367370 207367487 118 + 0.321 0.330 0.057
ENSG00000196352 E044 0.0000000       1 207370709 207370834 126 +      
ENSG00000196352 E045 3.1826088 0.1291577644 6.907049e-01 7.923383e-01 1 207372769 207373252 484 + 0.659 0.601 -0.251
ENSG00000196352 E046 0.2966881 0.0271206829 3.279376e-01   1 207385222 207385406 185 + 0.190 0.000 -11.831
ENSG00000196352 E047 0.1451727 0.0430170621 6.970288e-01   1 207386206 207386804 599 + 0.105 0.000 -10.831