ENSG00000196338

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358741 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding protein_coding 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.02694819 0.00000000 0.06544114 0.00000000 0.06544114 2.9153514 0.02965417 0.00000000 0.06693333 0.06693333 0.7994750250 2.43017e-05 FALSE TRUE
ENST00000476589 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding processed_transcript 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.15967362 0.10182732 0.17806460 0.10182732 0.17806460 0.7499556 0.17521250 0.09760000 0.18960000 0.09200000 1.0000000000 2.43017e-05 FALSE TRUE
ENST00000685718 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding nonsense_mediated_decay 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.03654491 0.00000000 0.11139583 0.00000000 0.05021505 3.6016470 0.04383333 0.00000000 0.11296667 0.11296667 0.0579709090 2.43017e-05 FALSE TRUE
ENST00000687470 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding protein_coding 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.05253761 0.06015108 0.09888238 0.01443265 0.02019000 0.6342333 0.05192917 0.06026667 0.09650000 0.03623333 0.8068840418 2.43017e-05 FALSE TRUE
ENST00000689968 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding protein_coding 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.01737992 0.13903938 0.00000000 0.13903938 0.00000000 -3.8976217 0.01985417 0.15883333 0.00000000 -0.15883333 0.7991514802 2.43017e-05 FALSE TRUE
ENST00000692338 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding protein_coding 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.06066742 0.00000000 0.34522332 0.00000000 0.18054869 5.1506544 0.06714583 0.00000000 0.32796667 0.32796667 0.1843843740 2.43017e-05 FALSE TRUE
ENST00000692468 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding retained_intron 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.34899470 0.57912206 0.00000000 0.16494387 0.00000000 -5.8804947 0.34096250 0.56776667 0.00000000 -0.56776667 0.0000243017 2.43017e-05 FALSE TRUE
ENST00000692800 ENSG00000196338 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN3 protein_coding retained_intron 0.9500584 0.9925007 1.009671 0.05870747 0.05241314 0.02450107 0.08593553 0.07527828 0.11592053 0.03044457 0.02190078 0.5622632 0.09068750 0.07856667 0.11320000 0.03463333 0.6779587009 2.43017e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196338 E001 0.0000000       X 71144821 71144840 20 +      
ENSG00000196338 E002 0.0000000       X 71144841 71144842 2 +      
ENSG00000196338 E003 0.0000000       X 71144843 71144845 3 +      
ENSG00000196338 E004 0.0000000       X 71144846 71144860 15 +      
ENSG00000196338 E005 0.0000000       X 71144861 71144871 11 +      
ENSG00000196338 E006 0.0000000       X 71144872 71144877 6 +      
ENSG00000196338 E007 0.0000000       X 71144878 71144964 87 +      
ENSG00000196338 E008 0.4375944 0.022975710 0.0878343067 0.171839363 X 71146509 71146547 39 + 0.290 0.000 -11.735
ENSG00000196338 E009 1.2502363 0.012996074 0.6856289060 0.788332791 X 71147550 71147627 78 + 0.291 0.369 0.490
ENSG00000196338 E010 2.4230673 0.268409969 0.8044087997 0.875574055 X 71147628 71147742 115 + 0.463 0.575 0.533
ENSG00000196338 E011 6.6753431 0.165259160 0.2216722782 0.352388109 X 71147743 71148062 320 + 0.982 0.765 -0.833
ENSG00000196338 E012 5.1756365 0.003460095 0.0028198796 0.009733579 X 71148063 71148206 144 + 0.951 0.565 -1.572
ENSG00000196338 E013 0.9244060 0.013241444 0.0954339017 0.183538342 X 71148207 71148663 457 + 0.413 0.125 -2.250
ENSG00000196338 E014 0.0000000       X 71148664 71148695 32 +      
ENSG00000196338 E015 0.3729606 0.029886096 0.9903352690 0.998085105 X 71148696 71148845 150 + 0.120 0.125 0.075
ENSG00000196338 E016 1.4038295 0.010151323 0.3300720989 0.473670739 X 71148846 71148905 60 + 0.463 0.301 -0.929
ENSG00000196338 E017 5.4445085 0.064273671 0.9139222918 0.949497044 X 71148906 71150675 1770 + 0.805 0.837 0.123
ENSG00000196338 E018 0.2214452 0.038111244 0.4774651237   X 71153456 71153476 21 + 0.000 0.125 11.956
ENSG00000196338 E019 3.1897052 0.011003188 0.0869045991 0.170441696 X 71153477 71153536 60 + 0.736 0.478 -1.148
ENSG00000196338 E020 6.1244523 0.031716782 0.0934777002 0.180555460 X 71155214 71155363 150 + 0.965 0.727 -0.926
ENSG00000196338 E021 0.1451727 0.042373663 0.4989293781   X 71161741 71164142 2402 + 0.120 0.000 -12.828
ENSG00000196338 E022 8.1593462 0.027586821 0.1561187744 0.269969453 X 71164143 71164328 186 + 1.047 0.867 -0.675
ENSG00000196338 E023 0.1515154 0.044993303 0.4967515457   X 71164329 71164817 489 + 0.120 0.000 -12.825
ENSG00000196338 E024 0.3666179 0.027652730 0.9860916309 0.995307656 X 71165986 71166049 64 + 0.120 0.125 0.075
ENSG00000196338 E025 0.8836079 0.013424868 0.0082951928 0.024531297 X 71166795 71167010 216 + 0.463 0.000 -14.895
ENSG00000196338 E026 21.7131269 0.027306762 0.2700475460 0.408624936 X 71167011 71167800 790 + 1.401 1.309 -0.317
ENSG00000196338 E027 0.8470867 0.014740701 0.6736939038 0.779316276 X 71167801 71168705 905 + 0.291 0.222 -0.511
ENSG00000196338 E028 0.0000000       X 71168706 71168715 10 +      
ENSG00000196338 E029 10.7278864 0.099373554 0.3386271638 0.482506702 X 71169254 71169532 279 + 1.125 1.005 -0.437
ENSG00000196338 E030 9.7958104 0.002557614 0.0937019768 0.180903914 X 71169533 71169744 212 + 0.919 1.103 0.678
ENSG00000196338 E031 34.8338817 0.029066853 0.0006386793 0.002675539 X 71169745 71171057 1313 + 1.365 1.667 1.035
ENSG00000196338 E032 2.1474590 0.014192743 0.7710083695 0.852179676 X 71171058 71171068 11 + 0.463 0.523 0.294
ENSG00000196338 E033 1.8454854 0.008133366 0.1210773903 0.221477385 X 71171069 71171111 43 + 0.291 0.564 1.486
ENSG00000196338 E034 1.3284980 0.010687807 0.1452098975 0.255127004 X 71171112 71171128 17 + 0.213 0.477 1.656
ENSG00000196338 E035 1.1769825 0.012198908 0.0462613400 0.102516956 X 71171129 71171146 18 + 0.120 0.477 2.655
ENSG00000196338 E036 0.8480291 0.015378759 0.0160455466 0.042837343 X 71171147 71171160 14 + 0.000 0.426 13.959
ENSG00000196338 E037 0.5514428 0.019934256 0.0803709187 0.160145877 X 71171161 71171199 39 + 0.000 0.301 13.354
ENSG00000196338 E038 0.0000000       X 71171200 71171201 2 +      
ENSG00000196338 E039 7.7737736 0.002675636 0.9358115164 0.963624568 X 71171433 71175255 3823 + 0.951 0.954 0.012