ENSG00000196323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000525842 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding protein_coding 12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 1.3620591 0.1836860 2.7727791 0.18368599 0.42982658 3.8447349 0.08249583 0.02836667 0.17033333 0.14196667 9.316416e-02 1.054554e-06 FALSE TRUE
ENST00000527478 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding protein_coding 12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 3.9550883 1.7015096 5.2046575 0.09754827 0.25917616 1.6073031 0.33240000 0.32136667 0.31736667 -0.00400000 1.000000e+00 1.054554e-06 FALSE TRUE
ENST00000528448 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding protein_coding 12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 1.4825623 0.3056005 2.2754990 0.20306994 0.34608933 2.8563379 0.09952500 0.05933333 0.13770000 0.07836667 3.808689e-01 1.054554e-06 FALSE FALSE
MSTRG.6582.10 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding   12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 1.2681742 0.4245554 1.7151752 0.04298438 0.06145281 1.9891307 0.08747083 0.08023333 0.10540000 0.02516667 5.424019e-01 1.054554e-06 FALSE TRUE
MSTRG.6582.12 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding   12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 0.4434751 0.4372184 0.5091678 0.03470622 0.17466080 0.2152214 0.04307083 0.08216667 0.03013333 -0.05203333 6.969950e-02 1.054554e-06   FALSE
MSTRG.6582.8 ENSG00000196323 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB44 protein_coding   12.30114 5.434016 16.43527 0.5219544 0.9588386 1.59493 1.7935107 1.6144751 1.2720885 0.21194279 0.21774530 -0.3414778 0.20046250 0.29946667 0.07666667 -0.22280000 1.054554e-06 1.054554e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196323 E001 0.1482932 0.0405540197 1.631643e-01   11 130226677 130226677 1 - 0.000 0.191 9.963
ENSG00000196323 E002 0.2998086 0.0284460704 4.430643e-01   11 130226678 130226683 6 - 0.076 0.191 1.531
ENSG00000196323 E003 227.7572559 0.0113872913 3.182063e-03 1.080306e-02 11 130226684 130228356 1673 - 2.264 2.434 0.565
ENSG00000196323 E004 198.8232045 0.0001999795 3.715443e-24 3.743468e-22 11 130228357 130229828 1472 - 2.331 2.026 -1.018
ENSG00000196323 E005 28.2490781 0.0136216782 5.812179e-03 1.811884e-02 11 130229829 130229974 146 - 1.491 1.218 -0.950
ENSG00000196323 E006 106.3332584 0.0155661756 9.632791e-05 5.048561e-04 11 130229975 130230978 1004 - 2.058 1.764 -0.987
ENSG00000196323 E007 116.6500857 0.0002785483 1.369872e-05 8.815152e-05 11 130230979 130231559 581 - 2.072 1.913 -0.534
ENSG00000196323 E008 41.8552118 0.0005197293 4.783626e-01 6.167818e-01 11 130231560 130231638 79 - 1.604 1.568 -0.124
ENSG00000196323 E009 28.3537105 0.0006805038 2.508617e-01 3.869735e-01 11 130231639 130231665 27 - 1.453 1.375 -0.269
ENSG00000196323 E010 36.4925120 0.0006026039 1.244415e-01 2.263112e-01 11 130231666 130231715 50 - 1.561 1.466 -0.325
ENSG00000196323 E011 231.3780818 0.0002161933 4.168738e-07 3.746465e-06 11 130231716 130233307 1592 - 2.361 2.234 -0.423
ENSG00000196323 E012 55.5208432 0.0004611813 2.558350e-06 1.945379e-05 11 130233308 130233382 75 - 1.630 1.866 0.799
ENSG00000196323 E013 91.7049525 0.0002951532 9.128687e-08 9.334498e-07 11 130233383 130233933 551 - 1.859 2.069 0.704
ENSG00000196323 E014 20.2861229 0.0009227227 9.933550e-03 2.859611e-02 11 130233934 130233950 17 - 1.222 1.432 0.730
ENSG00000196323 E015 29.8723046 0.0006529679 1.124074e-03 4.383982e-03 11 130233951 130234015 65 - 1.379 1.599 0.755
ENSG00000196323 E016 40.5853083 0.0005621015 5.063450e-05 2.849838e-04 11 130234016 130234155 140 - 1.502 1.738 0.802
ENSG00000196323 E017 58.0803719 0.0020927908 9.832446e-04 3.902389e-03 11 130234156 130234273 118 - 1.671 1.847 0.594
ENSG00000196323 E018 1.9198891 0.0083471782 9.492868e-02 1.827696e-01 11 130236110 130236216 107 - 0.518 0.191 -2.052
ENSG00000196323 E019 2.2194942 0.1615779439 5.722116e-01 6.983597e-01 11 130236631 130236792 162 - 0.435 0.621 0.887
ENSG00000196323 E020 48.3388865 0.0004836241 9.795488e-02 1.873903e-01 11 130236793 130237009 217 - 1.625 1.720 0.324
ENSG00000196323 E021 62.6840359 0.0004106611 1.553897e-02 4.170946e-02 11 130237010 130237093 84 - 1.726 1.846 0.406
ENSG00000196323 E022 92.6946113 0.0003100227 1.237168e-03 4.766646e-03 11 130238444 130238553 110 - 1.893 2.024 0.440
ENSG00000196323 E023 37.5789143 0.0007721312 7.562541e-03 2.267685e-02 11 130238554 130238556 3 - 1.500 1.666 0.568
ENSG00000196323 E024 49.3311714 0.0005388966 8.501395e-03 2.504181e-02 11 130238557 130238607 51 - 1.623 1.767 0.491
ENSG00000196323 E025 2.2070002 0.0074573732 5.457564e-03 1.717531e-02 11 130238815 130239811 997 - 0.588 0.000 -14.861
ENSG00000196323 E026 74.0372691 0.0004513249 1.921478e-01 3.164495e-01 11 130239812 130239896 85 - 1.821 1.885 0.217
ENSG00000196323 E027 94.7087053 0.0004189147 2.927337e-01 4.337227e-01 11 130260856 130261029 174 - 1.930 1.978 0.161
ENSG00000196323 E028 111.1516039 0.0003191315 1.868968e-01 3.098324e-01 11 130261030 130261255 226 - 2.024 1.981 -0.144
ENSG00000196323 E029 161.3818025 0.0002632407 9.721214e-02 1.862214e-01 11 130261256 130261929 674 - 2.185 2.141 -0.150
ENSG00000196323 E030 0.3030308 0.3587634224 8.350410e-01   11 130261930 130261931 2 - 0.141 0.000 -11.117
ENSG00000196323 E031 32.7599266 0.0544832961 6.246528e-01 7.409221e-01 11 130314375 130314917 543 - 1.505 1.445 -0.207