ENSG00000196296

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357084 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding protein_coding 2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.31552597 0.3601161 0.66074335 0.11446401 0.13445328 0.8577829 0.15303333 0.2461000 0.20833333 -0.037766667 8.953586e-01 7.432147e-06 FALSE TRUE
ENST00000564112 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding protein_coding 2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.64519439 0.0000000 0.92938056 0.00000000 0.19282241 6.5536378 0.22279583 0.0000000 0.30733333 0.307333333 7.432147e-06 7.432147e-06   FALSE
ENST00000564470 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding nonsense_mediated_decay 2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.06541278 0.1129977 0.08342902 0.01432585 0.08342902 -0.3966882 0.03413750 0.0754000 0.02346667 -0.051933333 2.570573e-01 7.432147e-06   FALSE
ENST00000564732 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding nonsense_mediated_decay 2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.08843285 0.0000000 0.40455828 0.00000000 0.24937507 5.3735030 0.02558333 0.0000000 0.12750000 0.127500000 3.261587e-01 7.432147e-06 FALSE FALSE
MSTRG.12373.3 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding   2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.19005838 0.1674798 0.46737965 0.16747981 0.15657345 1.4274822 0.08110417 0.1507000 0.15796667 0.007266667 5.845150e-01 7.432147e-06 FALSE TRUE
MSTRG.12373.9 ENSG00000196296 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A1 protein_coding   2.213662 1.504004 3.126501 0.2061234 0.2270793 1.050787 0.59873748 0.7338858 0.23097093 0.36716070 0.23097093 -1.6262221 0.32814583 0.4328667 0.06493333 -0.367933333 3.807804e-01 7.432147e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196296 E001 3.0539812 0.006036088 0.79823865 0.87120889 16 28878405 28878487 83 + 0.615 0.570 -0.203
ENSG00000196296 E002 5.2110963 0.004168999 0.02676236 0.06549656 16 28878488 28878789 302 + 0.913 0.608 -1.235
ENSG00000196296 E003 1.4048617 0.009567995 0.12039012 0.22052657 16 28878861 28878894 34 + 0.503 0.225 -1.690
ENSG00000196296 E004 1.1676105 0.255369440 0.01732792 0.04566631 16 28878895 28878950 56 + 0.542 0.000 -12.852
ENSG00000196296 E005 2.5757065 0.058456190 0.02329809 0.05837141 16 28878951 28879098 148 + 0.730 0.304 -2.107
ENSG00000196296 E006 2.1403021 0.269855998 0.21236983 0.34132642 16 28879099 28879116 18 + 0.647 0.303 -1.769
ENSG00000196296 E007 0.4375944 0.031796019 0.10170818 0.19309826 16 28879117 28879242 126 + 0.287 0.000 -11.444
ENSG00000196296 E008 0.9350151 0.223913750 0.22016373 0.35063140 16 28879243 28879500 258 + 0.410 0.127 -2.208
ENSG00000196296 E009 3.8888910 0.067182909 0.20349931 0.33059366 16 28879501 28879583 83 + 0.801 0.567 -0.983
ENSG00000196296 E010 1.1081856 0.084356680 0.65505373 0.76503911 16 28879584 28880052 469 + 0.287 0.370 0.521
ENSG00000196296 E011 0.4741261 0.021126607 0.62804717 0.74369575 16 28880053 28880059 7 + 0.211 0.127 -0.882
ENSG00000196296 E012 1.3190347 0.010673653 0.39897386 0.54272626 16 28880060 28880094 35 + 0.287 0.430 0.854
ENSG00000196296 E013 6.3578409 0.004265862 0.53617189 0.66792583 16 28880915 28881019 105 + 0.913 0.830 -0.320
ENSG00000196296 E014 10.3675447 0.001660223 0.51592859 0.65054138 16 28882451 28882589 139 + 1.016 1.074 0.211
ENSG00000196296 E015 8.5388208 0.002833748 0.29221395 0.43315589 16 28884575 28884655 81 + 0.913 1.021 0.401
ENSG00000196296 E016 11.4454538 0.001703013 0.58830919 0.71150769 16 28887189 28887274 86 + 1.065 1.109 0.159
ENSG00000196296 E017 17.9174057 0.013231120 0.94521844 0.96961662 16 28887425 28887662 238 + 1.274 1.272 -0.008
ENSG00000196296 E018 10.7173099 0.001927811 0.30591548 0.44805308 16 28887663 28887722 60 + 1.003 1.098 0.348
ENSG00000196296 E019 12.3402809 0.001700235 0.43691402 0.57894013 16 28888787 28888854 68 + 1.077 1.143 0.237
ENSG00000196296 E020 9.7690207 0.019641847 0.86897424 0.91979821 16 28888855 28888896 42 + 1.003 1.026 0.087
ENSG00000196296 E021 10.1515437 0.034115113 0.54827553 0.67813874 16 28888897 28888953 57 + 0.975 1.072 0.355
ENSG00000196296 E022 1.1188819 0.722242898 0.95465648 0.97557937 16 28892315 28892431 117 + 0.289 0.326 0.240
ENSG00000196296 E023 0.8544736 0.015044908 0.57828217 0.70341339 16 28892432 28892659 228 + 0.211 0.305 0.702
ENSG00000196296 E024 6.9146418 0.006773104 0.88788342 0.93232262 16 28894155 28894243 89 + 0.896 0.873 -0.091
ENSG00000196296 E025 4.0465217 0.055456718 0.15422226 0.26741241 16 28894505 28894607 103 + 0.822 0.567 -1.065
ENSG00000196296 E026 11.5411938 0.001661311 0.50782907 0.64325627 16 28894822 28894953 132 + 1.065 1.121 0.200
ENSG00000196296 E027 10.6714965 0.001803229 0.47689686 0.61550768 16 28898000 28898125 126 + 1.099 1.021 -0.284
ENSG00000196296 E028 15.6722766 0.007727883 0.04099643 0.09287584 16 28898233 28898451 219 + 1.316 1.120 -0.692
ENSG00000196296 E029 21.4166667 0.010962192 0.20546065 0.33298176 16 28900581 28900916 336 + 1.405 1.287 -0.412
ENSG00000196296 E030 12.5483277 0.001547316 0.36889455 0.51331279 16 28901863 28902083 221 + 1.088 1.163 0.269
ENSG00000196296 E031 16.4105826 0.001137011 0.12759363 0.23079420 16 28902184 28902386 203 + 1.169 1.286 0.413
ENSG00000196296 E032 12.7279146 0.001516763 0.21239860 0.34135528 16 28902580 28902665 86 + 1.065 1.173 0.388
ENSG00000196296 E033 14.8095349 0.001352972 0.79714273 0.87055645 16 28902778 28902911 134 + 1.178 1.193 0.053
ENSG00000196296 E034 14.7386747 0.001455973 0.86325537 0.91582137 16 28903030 28903147 118 + 1.196 1.173 -0.078
ENSG00000196296 E035 10.2504701 0.001710356 0.15473852 0.26807693 16 28903323 28903372 50 + 0.960 1.098 0.505
ENSG00000196296 E036 11.1642789 0.001591034 0.16284966 0.27885481 16 28903373 28903440 68 + 1.003 1.132 0.469
ENSG00000196296 E037 1.3265129 0.010409464 0.02021059 0.05192768 16 28903700 28903741 42 + 0.544 0.127 -2.884
ENSG00000196296 E038 1.3285892 0.009986859 0.02017369 0.05184693 16 28903742 28903826 85 + 0.544 0.127 -2.884
ENSG00000196296 E039 15.0869667 0.046764062 0.11017410 0.20579715 16 28904180 28904466 287 + 1.089 1.282 0.686