ENSG00000196290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359683 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding protein_coding 37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 4.7186606 2.898600 7.322243 1.0521901 0.6513085 1.3339296 0.13417500 0.12423333 0.15203333 0.027800000 7.834231e-01 1.994388e-25 FALSE TRUE
ENST00000409020 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding protein_coding 37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 6.1090539 3.579925 8.965187 0.5696551 0.5437750 1.3219883 0.15978750 0.15393333 0.18366667 0.029733333 2.385848e-01 1.994388e-25 FALSE TRUE
ENST00000426253 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding protein_coding 37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 3.1442392 0.000000 6.250683 0.0000000 0.8808709 9.2901761 0.06210417 0.00000000 0.12793333 0.127933333 1.994388e-25 1.994388e-25 FALSE FALSE
ENST00000454952 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding protein_coding 37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 5.4789897 3.279772 7.092816 0.4727425 0.3109327 1.1104037 0.15144167 0.14230000 0.14563333 0.003333333 9.423207e-01 1.994388e-25 FALSE FALSE
MSTRG.19745.1 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding   37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 0.8081966 2.210229 0.000000 1.1183584 0.0000000 -7.7945645 0.03645000 0.09286667 0.00000000 -0.092866667 3.553079e-05 1.994388e-25 FALSE TRUE
MSTRG.19745.2 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding   37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 3.8661683 3.328084 3.983667 0.9002769 2.0081422 0.2586938 0.10626667 0.15090000 0.07806667 -0.072833333 7.322041e-01 1.994388e-25 FALSE FALSE
MSTRG.19745.5 ENSG00000196290 HEK293_OSMI2_2hA HEK293_TMG_2hB NIF3L1 protein_coding   37.24712 23.46535 48.78681 4.320572 2.287383 1.05564 9.2596902 6.366636 10.986210 1.9883039 1.4330233 0.7861389 0.24587917 0.25953333 0.22540000 -0.034133333 8.973570e-01 1.994388e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196290 E001 0.5117019 0.0454903954 3.367184e-02 7.910209e-02 2 200889327 200889334 8 + 0.000 0.350 11.875
ENSG00000196290 E002 0.8082883 0.0148837302 3.943947e-03 1.298476e-02 2 200889335 200889347 13 + 0.000 0.487 15.101
ENSG00000196290 E003 5.5713225 0.0029786369 9.146630e-01 9.499827e-01 2 200889348 200889368 21 + 0.821 0.805 -0.063
ENSG00000196290 E004 6.6116546 0.0025610968 9.993167e-01 1.000000e+00 2 200889369 200889370 2 + 0.884 0.882 -0.005
ENSG00000196290 E005 26.1419366 0.0007781604 1.839854e-02 4.800765e-02 2 200889371 200889387 17 + 1.501 1.336 -0.569
ENSG00000196290 E006 27.5007147 0.0007411018 1.170251e-02 3.282555e-02 2 200889388 200889391 4 + 1.525 1.353 -0.594
ENSG00000196290 E007 10.5932324 0.0016630545 4.086581e-03 1.338527e-02 2 200889392 200889414 23 + 1.170 0.858 -1.153
ENSG00000196290 E008 28.4182019 0.0082476242 5.500380e-05 3.066870e-04 2 200889415 200889446 32 + 1.583 1.243 -1.178
ENSG00000196290 E009 114.1410853 0.0045231671 1.174991e-04 6.023889e-04 2 200889447 200889652 206 + 2.131 1.947 -0.617
ENSG00000196290 E010 10.4061368 0.0019053464 2.999519e-01 4.415684e-01 2 200889653 200889677 25 + 1.097 0.987 -0.404
ENSG00000196290 E011 8.7860840 0.0055376868 7.343486e-01 8.253420e-01 2 200890500 200890522 23 + 1.009 0.967 -0.154
ENSG00000196290 E012 13.7858688 0.0101607932 5.747028e-02 1.222965e-01 2 200890523 200890585 63 + 1.246 1.038 -0.744
ENSG00000196290 E013 22.3288532 0.0011253447 6.397359e-01 7.530792e-01 2 200891720 200891735 16 + 1.352 1.384 0.110
ENSG00000196290 E014 36.8482468 0.0043167509 8.187704e-01 8.854981e-01 2 200891736 200891789 54 + 1.587 1.563 -0.081
ENSG00000196290 E015 41.7034006 0.0009608062 5.519644e-01 6.813535e-01 2 200891790 200891916 127 + 1.646 1.610 -0.122
ENSG00000196290 E016 16.6576670 0.0019034096 9.443466e-01 9.691197e-01 2 200891917 200891917 1 + 1.252 1.244 -0.028
ENSG00000196290 E017 89.3576425 0.0003481039 1.830585e-02 4.780200e-02 2 200891918 200891968 51 + 1.996 1.905 -0.306
ENSG00000196290 E018 425.5263114 0.0001675982 7.803529e-06 5.314001e-05 2 200891969 200892379 411 + 2.664 2.588 -0.253
ENSG00000196290 E019 293.4844195 0.0006310174 8.507860e-01 9.074620e-01 2 200893246 200893408 163 + 2.476 2.468 -0.025
ENSG00000196290 E020 305.5316817 0.0001867879 9.806146e-01 9.918587e-01 2 200895264 200895390 127 + 2.491 2.489 -0.008
ENSG00000196290 E021 1.6555800 0.1588963445 2.909350e-01 4.317509e-01 2 200897074 200897075 2 + 0.518 0.261 -1.482
ENSG00000196290 E022 287.3825512 0.0003177673 2.122797e-03 7.604952e-03 2 200897076 200897214 139 + 2.436 2.498 0.205
ENSG00000196290 E023 173.3481589 0.0005587793 1.504458e-04 7.489752e-04 2 200899385 200899468 84 + 2.201 2.305 0.347
ENSG00000196290 E024 228.2818255 0.0002617998 2.347037e-07 2.220198e-06 2 200903494 200903669 176 + 2.312 2.430 0.394
ENSG00000196290 E025 190.3685058 0.0002163780 1.971712e-05 1.224785e-04 2 200903670 200904050 381 + 2.240 2.346 0.355