ENSG00000196236

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357137 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding protein_coding 11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 3.5504968 2.7849646 3.6887401 0.54999472 0.1526617 0.4042039 0.3060917 0.28743333 0.3342667 0.04683333 0.71319576 0.027272 FALSE TRUE
ENST00000482652 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding processed_transcript 11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 1.4312111 1.6148002 1.5038070 0.08133997 0.3701383 -0.1020810 0.1284750 0.16833333 0.1340000 -0.03433333 0.63117704 0.027272   FALSE
MSTRG.22174.2 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding   11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 0.8973428 1.1385242 1.3764280 0.18107787 0.6901103 0.2715914 0.0777375 0.12026667 0.1214667 0.00120000 0.90382845 0.027272 FALSE TRUE
MSTRG.22174.3 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding   11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 1.3051654 0.2832799 0.8348990 0.28327990 0.4630606 1.5265007 0.1058958 0.03040000 0.0760000 0.04560000 0.60782039 0.027272 FALSE TRUE
MSTRG.22174.5 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding   11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 1.4021449 0.1906736 2.2141696 0.19067359 0.1874789 3.4703441 0.1076500 0.01843333 0.2006667 0.18223333 0.02727200 0.027272 FALSE TRUE
MSTRG.22174.6 ENSG00000196236 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP3 protein_coding   11.57779 9.586987 11.04321 0.3884076 0.5376973 0.2038113 2.0554168 2.8355905 0.7427394 0.14429336 0.7427394 -1.9185056 0.1944417 0.29706667 0.0712000 -0.22586667 0.09914287 0.027272 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196236 E001 1.9625574 0.0110310397 7.632932e-02 1.536310e-01 22 40857077 40857089 13 + 0.287 0.607 1.699
ENSG00000196236 E002 3.4792929 0.0062065655 4.782582e-01 6.166891e-01 22 40857090 40857096 7 + 0.581 0.705 0.532
ENSG00000196236 E003 3.7717146 0.0043182779 7.822977e-01 8.602256e-01 22 40857097 40857102 6 + 0.647 0.705 0.242
ENSG00000196236 E004 19.8527584 0.0140630161 6.181024e-01 7.358245e-01 22 40857103 40857119 17 + 1.335 1.301 -0.117
ENSG00000196236 E005 25.1584834 0.0142366582 9.036165e-01 9.426725e-01 22 40857120 40857130 11 + 1.415 1.417 0.008
ENSG00000196236 E006 35.1175915 0.0153782145 7.928534e-01 8.675459e-01 22 40857131 40857147 17 + 1.537 1.570 0.113
ENSG00000196236 E007 109.3544824 0.0140065767 2.208654e-03 7.868936e-03 22 40857148 40857245 98 + 1.920 2.127 0.693
ENSG00000196236 E008 0.5546650 0.0218473074 5.455373e-01 6.758595e-01 22 40860678 40860793 116 + 0.118 0.225 1.119
ENSG00000196236 E009 69.9131933 0.0137362829 9.906747e-08 1.006599e-06 22 40861618 40861835 218 + 1.603 1.991 1.311
ENSG00000196236 E010 26.5671135 0.0224709813 9.189450e-01 9.527976e-01 22 40861836 40862265 430 + 1.445 1.441 -0.015
ENSG00000196236 E011 25.3812701 0.0039995199 3.894124e-03 1.284685e-02 22 40862266 40862679 414 + 1.289 1.524 0.814
ENSG00000196236 E012 4.1047335 0.0043209756 6.532991e-01 7.638152e-01 22 40862680 40862770 91 + 0.677 0.759 0.337
ENSG00000196236 E013 27.5987315 0.0007272732 3.986506e-03 1.310506e-02 22 40868999 40869018 20 + 1.541 1.375 -0.572
ENSG00000196236 E014 54.6739541 0.0004724441 4.715342e-05 2.673507e-04 22 40869019 40869115 97 + 1.828 1.657 -0.578
ENSG00000196236 E015 0.2934659 0.0282767361 1.000000e+00   22 40869992 40870047 56 + 0.118 0.127 0.115
ENSG00000196236 E016 6.6484018 0.0201536759 1.268454e-01 2.297550e-01 22 40870048 40870139 92 + 0.975 0.784 -0.733
ENSG00000196236 E017 0.1472490 0.0434378315 5.127866e-01   22 40870140 40870343 204 + 0.118 0.000 -10.031
ENSG00000196236 E018 112.3564367 0.0003054939 9.309218e-07 7.777058e-06 22 40881770 40882177 408 + 2.126 1.989 -0.461
ENSG00000196236 E019 70.7741977 0.0004129664 6.862066e-01 7.887637e-01 22 40886313 40886515 203 + 1.859 1.864 0.018
ENSG00000196236 E020 36.8985203 0.0005962455 3.778190e-01 5.221259e-01 22 40907587 40907649 63 + 1.599 1.571 -0.097
ENSG00000196236 E021 46.8819473 0.0048641551 7.362955e-01 8.268169e-01 22 40909122 40909235 114 + 1.686 1.686 0.000
ENSG00000196236 E022 44.4967993 0.0048229000 4.925562e-01 6.297123e-01 22 40914239 40914324 86 + 1.629 1.690 0.205
ENSG00000196236 E023 69.0246823 0.0071161819 2.179373e-01 3.479451e-01 22 40922333 40922513 181 + 1.801 1.887 0.291
ENSG00000196236 E024 61.0499784 0.0101907808 5.474580e-01 6.775168e-01 22 40924362 40924482 121 + 1.767 1.818 0.172
ENSG00000196236 E025 68.0687892 0.0004199220 6.154270e-01 7.336959e-01 22 40926269 40926463 195 + 1.842 1.842 0.000
ENSG00000196236 E026 31.4756995 0.0006562908 5.665839e-01 6.935325e-01 22 40926464 40926517 54 + 1.482 1.538 0.192
ENSG00000196236 E027 167.7283463 0.0005767202 4.861623e-03 1.554674e-02 22 40926518 40928469 1952 + 2.258 2.202 -0.187
ENSG00000196236 E028 407.1414175 0.0196739903 5.597004e-01 6.877824e-01 22 40928470 40932815 4346 + 2.611 2.611 0.000
ENSG00000196236 E029 0.8899626 0.0262668002 4.359609e-01 5.781005e-01 22 40933218 40933282 65 + 0.352 0.224 -0.888
ENSG00000196236 E030 0.1482932 0.0411597534 4.702207e-01   22 40933283 40933336 54 + 0.000 0.126 9.987
ENSG00000196236 E031 0.0000000       22 40945674 40945707 34 +