ENSG00000196235

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359191 ENSG00000196235 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT5H protein_coding protein_coding 96.69413 120.8407 71.60141 2.06873 1.184948 -0.7549649 10.578712 16.029711 8.7633884 1.293592 1.0323035 -0.8704421 0.10907083 0.13236667 0.122933333 -0.009433333 0.869697404 1.116512e-06 FALSE  
ENST00000432763 ENSG00000196235 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT5H protein_coding protein_coding 96.69413 120.8407 71.60141 2.06873 1.184948 -0.7549649 55.563342 74.802239 37.4672138 2.963490 1.3875278 -0.9972606 0.56826667 0.61853333 0.523000000 -0.095533333 0.008275367 1.116512e-06 FALSE  
ENST00000600818 ENSG00000196235 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT5H protein_coding retained_intron 96.69413 120.8407 71.60141 2.06873 1.184948 -0.7549649 8.892027 10.888942 5.3552989 3.420788 0.2839878 -1.0224576 0.08889167 0.09100000 0.074866667 -0.016133333 0.931234512 1.116512e-06 FALSE  
ENST00000601515 ENSG00000196235 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT5H protein_coding protein_coding 96.69413 120.8407 71.60141 2.06873 1.184948 -0.7549649 4.454328 3.104558 7.1395876 3.104558 0.2845325 1.1988328 0.05269167 0.02486667 0.099800000 0.074933333 0.093254399 1.116512e-06 FALSE  
MSTRG.17134.6 ENSG00000196235 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT5H protein_coding   96.69413 120.8407 71.60141 2.06873 1.184948 -0.7549649 4.148956 8.437163 0.5627496 1.791660 0.5627496 -3.8824906 0.03580833 0.07033333 0.008033333 -0.062300000 0.061905718 1.116512e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196235 E001 0.0000000       19 39436156 39436177 22 +      
ENSG00000196235 E002 0.0000000       19 39439572 39439796 225 +      
ENSG00000196235 E003 0.0000000       19 39439797 39439841 45 +      
ENSG00000196235 E004 0.1482932 0.0415163655 1.000000e+00   19 39439940 39439984 45 + 0.000 0.088 8.870
ENSG00000196235 E005 0.0000000       19 39441290 39441441 152 +      
ENSG00000196235 E006 0.0000000       19 39441643 39441725 83 +      
ENSG00000196235 E007 0.9556391 0.0124999673 3.520456e-01 4.962867e-01 19 39445441 39445545 105 + 0.382 0.224 -1.059
ENSG00000196235 E008 1.2512830 0.0106070545 1.269333e-02 3.519060e-02 19 39445546 39445557 12 + 0.582 0.162 -2.643
ENSG00000196235 E009 5.1145993 0.0039802589 1.478356e-03 5.567332e-03 19 39445558 39445577 20 + 0.997 0.595 -1.606
ENSG00000196235 E010 7.2611132 0.0022368401 1.892184e-03 6.889915e-03 19 39445578 39445581 4 + 1.089 0.741 -1.321
ENSG00000196235 E011 24.7417150 0.0008138829 3.408656e-04 1.543808e-03 19 39445582 39445592 11 + 1.524 1.290 -0.810
ENSG00000196235 E012 60.4670144 0.0004440379 1.797089e-02 4.707203e-02 19 39445593 39445607 15 + 1.806 1.710 -0.323
ENSG00000196235 E013 202.3994836 0.0079158126 2.873223e-03 9.893194e-03 19 39445608 39445637 30 + 2.350 2.220 -0.432
ENSG00000196235 E014 35.3622432 0.0049201124 2.726699e-02 6.653422e-02 19 39445644 39445683 40 + 1.602 1.467 -0.460
ENSG00000196235 E015 88.3838900 0.0076111316 2.849137e-01 4.252091e-01 19 39445684 39445803 120 + 1.934 1.891 -0.146
ENSG00000196235 E016 374.6800261 0.0034960003 1.173879e-02 3.291125e-02 19 39445804 39445878 75 + 2.574 2.508 -0.221
ENSG00000196235 E017 239.2994651 0.0013611553 1.860951e-03 6.792309e-03 19 39445879 39445881 3 + 2.385 2.311 -0.248
ENSG00000196235 E018 493.6807878 0.0044008939 4.210028e-03 1.373121e-02 19 39445882 39445965 84 + 2.706 2.623 -0.276
ENSG00000196235 E019 733.4307808 0.0021963722 2.601908e-02 6.398444e-02 19 39453356 39453521 166 + 2.848 2.809 -0.128
ENSG00000196235 E020 419.8677459 0.0003668953 6.971072e-05 3.785938e-04 19 39457675 39457700 26 + 2.622 2.560 -0.205
ENSG00000196235 E021 441.1980611 0.0013854575 3.917349e-02 8.950168e-02 19 39457701 39457740 40 + 2.623 2.591 -0.108
ENSG00000196235 E022 12.2872078 0.0013727370 3.116681e-06 2.322669e-05 19 39457741 39457949 209 + 1.336 0.915 -1.518
ENSG00000196235 E023 11.6370843 0.0015804718 4.973756e-02 1.086959e-01 19 39458176 39458293 118 + 1.179 1.001 -0.643
ENSG00000196235 E024 275.1526543 0.0004714899 9.851195e-01 9.947102e-01 19 39458294 39458305 12 + 2.382 2.401 0.063
ENSG00000196235 E025 30.8006941 0.0048005633 3.068578e-08 3.446909e-07 19 39458352 39458817 466 + 1.685 1.315 -1.272
ENSG00000196235 E026 492.9106445 0.0004438878 3.478710e-03 1.166352e-02 19 39458818 39458887 70 + 2.674 2.636 -0.127
ENSG00000196235 E027 483.7459549 0.0001651672 6.321742e-08 6.672433e-07 19 39459005 39459073 69 + 2.693 2.615 -0.259
ENSG00000196235 E028 440.5695469 0.0002867018 1.925986e-03 6.996457e-03 19 39459184 39459249 66 + 2.627 2.585 -0.139
ENSG00000196235 E029 362.0193578 0.0003432437 9.134237e-04 3.661329e-03 19 39459559 39459589 31 + 2.550 2.497 -0.175
ENSG00000196235 E030 484.8500651 0.0001676146 1.532946e-06 1.222994e-05 19 39459892 39459960 69 + 2.687 2.620 -0.223
ENSG00000196235 E031 0.1482932 0.0415163655 1.000000e+00   19 39459961 39460125 165 + 0.000 0.088 8.857
ENSG00000196235 E032 1002.1536604 0.0012982062 6.260701e-05 3.442077e-04 19 39464798 39465049 252 + 2.999 2.937 -0.208
ENSG00000196235 E033 1.7433034 0.2052980583 4.889594e-01 6.264626e-01 19 39466473 39466479 7 + 0.526 0.366 -0.832
ENSG00000196235 E034 631.4010003 0.0011206481 4.080587e-03 1.336957e-02 19 39466480 39466569 90 + 2.785 2.742 -0.144
ENSG00000196235 E035 536.1850321 0.0020119018 7.891752e-03 2.350700e-02 19 39466675 39466745 71 + 2.721 2.670 -0.172
ENSG00000196235 E036 8.8938806 0.0018964838 1.797477e-07 1.738623e-06 19 39466746 39467091 346 + 1.264 0.723 -2.020
ENSG00000196235 E037 38.8010957 0.0089121870 4.880674e-11 9.083692e-10 19 39467454 39468755 1302 + 1.825 1.369 -1.554
ENSG00000196235 E038 631.4729797 0.0013425654 4.640943e-02 1.027730e-01 19 39468756 39468861 106 + 2.773 2.747 -0.086
ENSG00000196235 E039 643.5953050 0.0010121227 1.320183e-03 5.044469e-03 19 39469079 39469172 94 + 2.796 2.748 -0.161
ENSG00000196235 E040 768.3805280 0.0002209024 1.822689e-04 8.876680e-04 19 39469262 39469398 137 + 2.866 2.828 -0.125
ENSG00000196235 E041 3.5396457 0.0046419121 2.816620e-01 4.215785e-01 19 39469563 39470118 556 + 0.718 0.569 -0.643
ENSG00000196235 E042 758.3084458 0.0001542675 1.218098e-01 2.225011e-01 19 39470119 39470274 156 + 2.837 2.833 -0.012
ENSG00000196235 E043 723.4412859 0.0001092342 1.675643e-02 4.439984e-02 19 39470377 39470523 147 + 2.825 2.809 -0.054
ENSG00000196235 E044 598.8764645 0.0001127855 3.865243e-01 5.307030e-01 19 39471357 39471440 84 + 2.728 2.734 0.017
ENSG00000196235 E045 541.4166664 0.0007189028 3.990440e-01 5.427905e-01 19 39471441 39471503 63 + 2.688 2.690 0.008
ENSG00000196235 E046 618.7854722 0.0001499664 9.424760e-02 1.817628e-01 19 39471605 39471730 126 + 2.711 2.758 0.156
ENSG00000196235 E047 0.1472490 0.0430598849 2.257197e-01   19 39471731 39471864 134 + 0.167 0.000 -11.252
ENSG00000196235 E048 370.0190681 0.0006511535 2.417477e-05 1.471575e-04 19 39472409 39472493 85 + 2.432 2.553 0.406
ENSG00000196235 E049 525.8786968 0.0011736281 8.180846e-07 6.922313e-06 19 39472810 39472929 120 + 2.570 2.710 0.465
ENSG00000196235 E050 489.5053849 0.0001325344 2.234633e-07 2.122511e-06 19 39473012 39473114 103 + 2.557 2.673 0.386
ENSG00000196235 E051 567.1956778 0.0001314672 4.491053e-04 1.963415e-03 19 39473203 39473330 128 + 2.650 2.729 0.265
ENSG00000196235 E052 531.4051033 0.0012551443 5.002082e-02 1.092105e-01 19 39473416 39473521 106 + 2.631 2.699 0.227
ENSG00000196235 E053 603.9741453 0.0028910817 1.296560e-03 4.964918e-03 19 39473963 39474121 159 + 2.646 2.768 0.405
ENSG00000196235 E054 800.5533860 0.0033017598 3.811073e-06 2.786352e-05 19 39474234 39474402 169 + 2.734 2.901 0.555
ENSG00000196235 E055 1196.9161044 0.0024134215 2.519379e-08 2.880372e-07 19 39474515 39474718 204 + 2.908 3.075 0.556
ENSG00000196235 E056 49.6615245 0.0082729748 6.126099e-10 9.454754e-09 19 39474719 39475225 507 + 1.898 1.508 -1.322
ENSG00000196235 E057 38.3540303 0.0133904336 2.319313e-07 2.196495e-06 19 39475874 39476080 207 + 1.789 1.406 -1.308
ENSG00000196235 E058 922.8033323 0.0041786957 4.700062e-05 2.665826e-04 19 39476081 39476176 96 + 2.801 2.961 0.534
ENSG00000196235 E059 1349.0555975 0.0034119081 1.030756e-10 1.815148e-09 19 39476256 39476670 415 + 2.922 3.137 0.715