ENSG00000196233

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371103 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding protein_coding 6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.8751335 0.03998611 2.3093575 0.03998611 0.42381027 5.536054 0.10642917 0.01080000 0.28006667 0.26926667 1.995081e-04 9.246806e-16 FALSE TRUE
ENST00000421806 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding protein_coding 6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.3218091 0.90473872 0.0000000 0.10016767 0.00000000 -6.515288 0.06527500 0.23576667 0.00000000 -0.23576667 9.246806e-16 9.246806e-16 FALSE TRUE
ENST00000463415 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding processed_transcript 6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.5555350 0.73977008 0.3409544 0.17780493 0.26746173 -1.095165 0.10346667 0.19316667 0.03906667 -0.15410000 1.431814e-01 9.246806e-16   FALSE
ENST00000676067 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding nonsense_mediated_decay 6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.2746574 0.04954405 0.5586023 0.04954405 0.09122116 3.255391 0.03408333 0.01050000 0.06676667 0.05626667 4.705550e-02 9.246806e-16 FALSE TRUE
ENST00000676257 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding nonsense_mediated_decay 6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.4925262 0.05693669 0.7472620 0.05693669 0.41581941 3.499923 0.05831667 0.01670000 0.08803333 0.07133333 6.013341e-01 9.246806e-16 FALSE TRUE
MSTRG.4433.11 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding   6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 1.0713799 0.28044470 1.9606838 0.28044470 0.11758217 2.762361 0.14779583 0.08226667 0.23453333 0.15226667 1.788125e-01 9.246806e-16 FALSE TRUE
MSTRG.4433.19 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding   6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 1.5626820 1.41762671 0.5054890 0.33454916 0.07897965 -1.469605 0.31118333 0.35020000 0.06043333 -0.28976667 6.019788e-09 9.246806e-16 FALSE TRUE
MSTRG.4433.2 ENSG00000196233 HEK293_OSMI2_2hA HEK293_TMG_2hB LCOR protein_coding   6.41861 3.943216 8.357142 0.3969248 0.3116297 1.081708 0.1026860 0.00000000 0.4598675 0.00000000 0.27985557 5.554182 0.01227083 0.00000000 0.05623333 0.05623333 3.260289e-01 9.246806e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196233 E001 0.1472490 0.0424221023 8.769734e-01   10 96832254 96832258 5 + 0.078 0.000 -9.211
ENSG00000196233 E002 0.1472490 0.0424221023 8.769734e-01   10 96832259 96832259 1 + 0.078 0.000 -10.668
ENSG00000196233 E003 0.1472490 0.0424221023 8.769734e-01   10 96832260 96832262 3 + 0.078 0.000 -10.668
ENSG00000196233 E004 0.1472490 0.0424221023 8.769734e-01   10 96832263 96832263 1 + 0.078 0.000 -10.668
ENSG00000196233 E005 0.5159433 0.2120261938 1.000000e+00 1.000000e+00 10 96832264 96832270 7 + 0.143 0.190 0.490
ENSG00000196233 E006 0.9556140 0.2665839876 4.681114e-01 6.075379e-01 10 96832271 96832271 1 + 0.296 0.191 -0.824
ENSG00000196233 E007 1.2480357 0.2610524771 2.918409e-01 4.327519e-01 10 96832272 96832279 8 + 0.374 0.191 -1.309
ENSG00000196233 E008 1.3952847 0.3327689078 2.851156e-01 4.254187e-01 10 96832280 96832280 1 + 0.408 0.191 -1.494
ENSG00000196233 E009 1.3952847 0.3327689078 2.851156e-01 4.254187e-01 10 96832281 96832281 1 + 0.408 0.191 -1.494
ENSG00000196233 E010 4.2320897 0.0775206942 1.404416e-01 2.486355e-01 10 96832282 96832297 16 + 0.724 0.573 -0.649
ENSG00000196233 E011 4.9737591 0.0066178612 4.479018e-02 9.981844e-02 10 96832298 96832302 5 + 0.784 0.628 -0.646
ENSG00000196233 E012 8.9585948 0.0040145389 1.052413e-03 4.140650e-03 10 96832303 96832314 12 + 1.025 0.769 -0.975
ENSG00000196233 E013 9.5132598 0.0047950323 4.092184e-03 1.340107e-02 10 96832315 96832318 4 + 1.033 0.843 -0.714
ENSG00000196233 E014 17.8621211 0.0010308563 7.096518e-06 4.879671e-05 10 96832319 96832395 77 + 1.301 1.053 -0.883
ENSG00000196233 E015 9.4830592 0.0020607393 2.821868e-04 1.307237e-03 10 96832396 96832399 4 + 1.056 0.769 -1.089
ENSG00000196233 E016 0.2987644 0.0290785164 4.227013e-01   10 96832906 96832935 30 + 0.143 0.000 -11.751
ENSG00000196233 E017 0.4470576 0.0228172848 9.858795e-01 9.951903e-01 10 96832936 96832948 13 + 0.143 0.188 0.466
ENSG00000196233 E018 0.4470576 0.0228172848 9.858795e-01 9.951903e-01 10 96832949 96832954 6 + 0.143 0.188 0.466
ENSG00000196233 E019 0.5943067 0.0204977706 6.654550e-01 7.731368e-01 10 96832955 96832979 25 + 0.201 0.188 -0.119
ENSG00000196233 E020 0.6244956 0.0324708621 5.579257e-01 6.862574e-01 10 96832980 96833024 45 + 0.143 0.318 1.466
ENSG00000196233 E021 0.7760110 0.0152816871 8.319619e-01 8.947031e-01 10 96833025 96833029 5 + 0.201 0.318 0.882
ENSG00000196233 E022 0.4815130 0.0202910425 2.765630e-01 4.160171e-01 10 96833030 96833031 2 + 0.078 0.318 2.467
ENSG00000196233 E023 0.4815130 0.0202910425 2.765630e-01 4.160171e-01 10 96833032 96833041 10 + 0.078 0.318 2.467
ENSG00000196233 E024 0.7780993 0.0360930945 4.831127e-02 1.061812e-01 10 96833042 96833114 73 + 0.078 0.499 3.460
ENSG00000196233 E025 0.1515154 0.0424107984 8.770152e-01   10 96833115 96833118 4 + 0.078 0.000 -10.669
ENSG00000196233 E026 0.0000000       10 96833119 96833122 4 +      
ENSG00000196233 E027 0.1515154 0.0424107984 8.770152e-01   10 96833123 96833405 283 + 0.078 0.000 -10.669
ENSG00000196233 E028 13.7485205 0.0013295512 3.317329e-02 7.814898e-02 10 96833406 96833479 74 + 1.149 1.111 -0.138
ENSG00000196233 E029 0.3332198 0.0290279474 6.584366e-01   10 96833723 96833776 54 + 0.078 0.188 1.469
ENSG00000196233 E030 2.2874505 0.0064158885 1.984769e-01 3.243041e-01 10 96833777 96833841 65 + 0.525 0.419 -0.532
ENSG00000196233 E031 1.2857384 0.0125146120 9.001071e-01 9.402580e-01 10 96858292 96858416 125 + 0.296 0.419 0.732
ENSG00000196233 E032 4.0146005 0.2201760399 3.981921e-02 9.069479e-02 10 96884403 96884708 306 + 0.408 0.983 2.463
ENSG00000196233 E033 0.2924217 0.0294492677 4.226181e-01   10 96886063 96886155 93 + 0.143 0.000 -11.747
ENSG00000196233 E034 15.4770737 0.0030764985 1.647232e-09 2.345432e-08 10 96907265 96907284 20 + 1.283 0.769 -1.900
ENSG00000196233 E035 13.4100493 0.0149946356 6.217063e-07 5.398065e-06 10 96907285 96907285 1 + 1.221 0.728 -1.848
ENSG00000196233 E036 18.4172106 0.0052182493 5.330544e-11 9.848553e-10 10 96907286 96907330 45 + 1.360 0.807 -2.016
ENSG00000196233 E037 23.2603458 0.0008231924 3.444333e-13 9.072839e-12 10 96907668 96907747 80 + 1.450 0.960 -1.744
ENSG00000196233 E038 0.1472490 0.0424221023 8.769734e-01   10 96907748 96908090 343 + 0.078 0.000 -10.668
ENSG00000196233 E039 0.1817044 0.0394739296 2.692239e-01   10 96944102 96944112 11 + 0.000 0.188 11.501
ENSG00000196233 E040 19.9328628 0.0009119429 2.487894e-09 3.428061e-08 10 96944113 96944245 133 + 1.371 0.985 -1.377
ENSG00000196233 E041 0.0000000       10 96944246 96944315 70 +      
ENSG00000196233 E042 35.9843296 0.0007120805 6.486455e-14 1.893065e-12 10 96949008 96949222 215 + 1.614 1.263 -1.211
ENSG00000196233 E043 27.2304884 0.0016276348 3.641823e-07 3.311411e-06 10 96949223 96949295 73 + 1.471 1.250 -0.767
ENSG00000196233 E044 1.7609973 0.0695531714 6.250328e-01 7.412290e-01 10 96949296 96951035 1740 + 0.409 0.421 0.064
ENSG00000196233 E045 0.0000000       10 96951036 96951065 30 +      
ENSG00000196233 E046 0.1472490 0.0424221023 8.769734e-01   10 96951066 96952102 1037 + 0.078 0.000 -10.668
ENSG00000196233 E047 31.7822497 0.0312286841 2.334103e-04 1.105832e-03 10 96952103 96952196 94 + 1.538 1.304 -0.808
ENSG00000196233 E048 46.3757847 0.0034486314 1.618568e-38 5.093570e-36 10 96954953 96955454 502 + 1.780 0.769 -3.604
ENSG00000196233 E049 24.1714467 0.0048216129 1.735352e-22 1.465050e-20 10 96955455 96955671 217 + 1.506 0.500 -3.844
ENSG00000196233 E050 20.1287093 0.0009000285 4.831176e-19 2.759276e-17 10 96955672 96955834 163 + 1.422 0.569 -3.232
ENSG00000196233 E051 13.3950035 0.0094070375 8.340112e-11 1.491982e-09 10 96955835 96955957 123 + 1.247 0.501 -2.941
ENSG00000196233 E052 120.2407302 0.0003094416 4.080157e-91 9.312935e-88 10 96955958 96958411 2454 + 2.174 1.395 -2.638
ENSG00000196233 E053 450.7870297 0.0149349319 3.080633e-15 1.093939e-13 10 96958412 96964441 6030 + 2.678 2.445 -0.777
ENSG00000196233 E054 1092.1370172 0.0025517306 1.888370e-174 3.577461e-170 10 96980793 96995956 15164 + 2.760 3.299 1.793