ENSG00000196208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389825 ENSG00000196208 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1 protein_coding protein_coding 3.296371 5.777503 3.651108 1.313823 0.0676408 -0.6606609 0.7540572 1.8638714 0.5060923 0.13063255 0.07444915 -1.8603210 0.19469583 0.34466667 0.13946667 -0.20520000 0.01278313 0.01278313 FALSE TRUE
ENST00000628795 ENSG00000196208 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1 protein_coding protein_coding 3.296371 5.777503 3.651108 1.313823 0.0676408 -0.6606609 0.3629243 1.2766945 0.3549193 1.27669450 0.18580282 -1.8180203 0.07214583 0.15246667 0.09573333 -0.05673333 0.68344641 0.01278313   FALSE
MSTRG.17966.14 ENSG00000196208 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1 protein_coding   3.296371 5.777503 3.651108 1.313823 0.0676408 -0.6606609 0.6235641 1.1477757 0.6358869 0.23189317 0.08216107 -0.8420022 0.19527083 0.22820000 0.17343333 -0.05476667 0.85890695 0.01278313 FALSE TRUE
MSTRG.17966.2 ENSG00000196208 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1 protein_coding   3.296371 5.777503 3.651108 1.313823 0.0676408 -0.6606609 0.9705062 0.8653891 1.4756545 0.12217622 0.25936695 0.7631024 0.33291250 0.16940000 0.40413333 0.23473333 0.08807500 0.01278313 FALSE TRUE
MSTRG.17966.3 ENSG00000196208 HEK293_OSMI2_2hA HEK293_TMG_2hB GREB1 protein_coding   3.296371 5.777503 3.651108 1.313823 0.0676408 -0.6606609 0.3028907 0.1281317 0.4905651 0.06543579 0.20664887 1.8575131 0.12712500 0.02023333 0.13516667 0.11493333 0.15473742 0.01278313 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196208 E001 0.0000000       2 11482341 11482381 41 +      
ENSG00000196208 E002 6.1819853 0.0036588595 7.059779e-01 8.042272e-01 2 11482868 11482925 58 + 0.869 0.840 -0.114
ENSG00000196208 E003 6.7743043 0.0024489662 2.082637e-01 3.363993e-01 2 11482926 11482963 38 + 0.950 0.817 -0.509
ENSG00000196208 E004 0.0000000       2 11534045 11534254 210 +      
ENSG00000196208 E005 0.0000000       2 11539843 11540108 266 +      
ENSG00000196208 E006 0.0000000       2 11542690 11542724 35 +      
ENSG00000196208 E007 0.0000000       2 11542725 11542817 93 +      
ENSG00000196208 E008 0.0000000       2 11542818 11542827 10 +      
ENSG00000196208 E009 0.1482932 0.0418234752 4.512394e-01   2 11556353 11556453 101 + 0.000 0.129 10.402
ENSG00000196208 E010 5.1952148 0.0060674425 6.400001e-02 1.333518e-01 2 11556454 11556456 3 + 0.887 0.652 -0.944
ENSG00000196208 E011 25.0416538 0.0288512088 7.511008e-01 8.376283e-01 2 11556457 11556617 161 + 1.383 1.444 0.211
ENSG00000196208 E012 28.6802832 0.0030182891 7.043038e-02 1.440630e-01 2 11556618 11556771 154 + 1.394 1.536 0.490
ENSG00000196208 E013 22.8206800 0.0011687278 7.264672e-03 2.191304e-02 2 11562463 11562582 120 + 1.257 1.470 0.740
ENSG00000196208 E014 0.1451727 0.0432807076 5.271298e-01   2 11562583 11563141 559 + 0.115 0.000 -11.047
ENSG00000196208 E015 24.0084450 0.0008070826 1.095034e-03 4.287238e-03 2 11566480 11566656 177 + 1.249 1.500 0.869
ENSG00000196208 E016 32.7743104 0.0019446775 4.557500e-03 1.470326e-02 2 11576353 11576535 183 + 1.415 1.613 0.679
ENSG00000196208 E017 29.0172808 0.0011254151 3.798600e-03 1.257792e-02 2 11578297 11578431 135 + 1.349 1.558 0.721
ENSG00000196208 E018 26.6108572 0.0007535609 8.493057e-02 1.672975e-01 2 11580704 11580832 129 + 1.360 1.495 0.464
ENSG00000196208 E019 18.9476124 0.0010555556 9.538744e-11 1.688392e-09 2 11580833 11581265 433 + 0.920 1.490 2.032
ENSG00000196208 E020 9.7903775 0.0018093495 1.491444e-04 7.433561e-04 2 11585161 11585274 114 + 1.185 0.794 -1.457
ENSG00000196208 E021 11.9173299 0.0022961558 5.521622e-07 4.845538e-06 2 11585762 11585905 144 + 1.292 0.794 -1.833
ENSG00000196208 E022 1.2146350 0.0880150698 6.290091e-01 7.444670e-01 2 11587382 11588243 862 + 0.282 0.380 0.617
ENSG00000196208 E023 0.6600969 0.0837728787 9.393463e-01 9.659046e-01 2 11588256 11588745 490 + 0.207 0.230 0.193
ENSG00000196208 E024 16.3044933 0.0394113653 1.070741e-03 4.203596e-03 2 11588746 11588931 186 + 1.389 0.995 -1.402
ENSG00000196208 E025 1.4652396 0.0118639495 8.411026e-01 9.008818e-01 2 11591396 11592146 751 + 0.402 0.379 -0.131
ENSG00000196208 E026 15.1837168 0.0128663458 4.729806e-04 2.056759e-03 2 11592776 11593126 351 + 1.343 1.004 -1.206
ENSG00000196208 E027 11.9796707 0.0014544765 1.139491e-05 7.474312e-05 2 11595251 11595379 129 + 1.278 0.861 -1.522
ENSG00000196208 E028 14.9399025 0.0013958063 1.447400e-05 9.263388e-05 2 11596111 11596239 129 + 1.355 0.986 -1.316
ENSG00000196208 E029 16.6922401 0.0011291681 5.039825e-06 3.584277e-05 2 11597781 11597978 198 + 1.399 1.031 -1.306
ENSG00000196208 E030 16.1443753 0.0011449651 4.194760e-03 1.369084e-02 2 11598680 11598860 181 + 1.331 1.108 -0.788
ENSG00000196208 E031 3.7363300 0.0043501357 2.111834e-01 3.399097e-01 2 11600800 11600802 3 + 0.746 0.578 -0.716
ENSG00000196208 E032 14.2838080 0.0254815815 3.116106e-01 4.540774e-01 2 11600803 11600995 193 + 1.219 1.126 -0.330
ENSG00000196208 E033 11.6727078 0.0429078930 8.642134e-02 1.696819e-01 2 11602406 11602542 137 + 1.186 0.980 -0.746
ENSG00000196208 E034 17.3333273 0.0010904851 1.444379e-02 3.922944e-02 2 11610688 11611027 340 + 1.343 1.163 -0.632
ENSG00000196208 E035 0.0000000       2 11612259 11612342 84 +      
ENSG00000196208 E036 0.0000000       2 11612343 11612376 34 +      
ENSG00000196208 E037 0.1515154 0.0427124204 5.271233e-01   2 11612377 11612494 118 + 0.116 0.000 -11.051
ENSG00000196208 E038 11.0115897 0.0080391607 4.283144e-02 9.623321e-02 2 11612495 11612610 116 + 1.167 0.971 -0.714
ENSG00000196208 E039 18.7361959 0.0057095612 3.059942e-01 4.481403e-01 2 11615091 11615290 200 + 1.331 1.264 -0.232
ENSG00000196208 E040 11.9610630 0.0154142284 3.223360e-01 4.656554e-01 2 11616631 11616720 90 + 1.158 1.070 -0.316
ENSG00000196208 E041 19.1143519 0.0074116229 5.711326e-01 6.974830e-01 2 11618288 11618586 299 + 1.318 1.289 -0.103
ENSG00000196208 E042 19.8878382 0.0012181259 1.363099e-01 2.429077e-01 2 11618587 11618919 333 + 1.366 1.272 -0.327
ENSG00000196208 E043 11.9279662 0.0017947420 1.130470e-01 2.099834e-01 2 11620905 11621007 103 + 1.176 1.044 -0.476
ENSG00000196208 E044 16.8652252 0.0010581373 1.850341e-01 3.075358e-01 2 11625154 11625312 159 + 1.292 1.203 -0.314
ENSG00000196208 E045 18.6451410 0.0009794732 9.425750e-03 2.734579e-02 2 11626962 11627104 143 + 1.377 1.193 -0.646
ENSG00000196208 E046 17.7421186 0.0010340809 5.238680e-04 2.248929e-03 2 11629948 11630109 162 + 1.383 1.120 -0.928
ENSG00000196208 E047 22.2270200 0.0040223790 1.524516e-02 4.104177e-02 2 11631909 11632113 205 + 1.435 1.266 -0.587
ENSG00000196208 E048 22.2218609 0.0009362888 7.486333e-01 8.358016e-01 2 11632889 11633063 175 + 1.337 1.379 0.148
ENSG00000196208 E049 25.4040623 0.0043677910 2.779590e-01 4.175998e-01 2 11634131 11634349 219 + 1.366 1.465 0.341
ENSG00000196208 E050 17.2647310 0.0073261215 4.027350e-01 5.465201e-01 2 11635270 11635405 136 + 1.210 1.304 0.328
ENSG00000196208 E051 25.2257728 0.0053452747 7.910296e-01 8.663474e-01 2 11637716 11637916 201 + 1.389 1.429 0.139
ENSG00000196208 E052 14.6551364 0.0014392314 2.795502e-02 6.792784e-02 2 11638671 11638809 139 + 1.067 1.281 0.762
ENSG00000196208 E053 199.8189135 0.0060577711 5.960616e-07 5.195164e-06 2 11640291 11642788 2498 + 2.180 2.391 0.707