ENSG00000196155

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379344 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding protein_coding 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 2.874611 3.498270 4.045743 1.16451789 0.67395712 0.209206250 0.15928333 0.13130000 0.22253333 0.09123333 0.387332733 0.005340072 FALSE TRUE
ENST00000393966 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding nonsense_mediated_decay 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.092275 1.011670 1.029667 0.26554577 0.10641461 0.025191736 0.07124167 0.03590000 0.05670000 0.02080000 0.280323281 0.005340072 FALSE TRUE
ENST00000427155 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding protein_coding 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.044356 3.348106 0.000000 1.67924838 0.00000000 -8.391504050 0.06102500 0.11760000 0.00000000 -0.11760000 0.179823624 0.005340072 FALSE TRUE
ENST00000450733 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding protein_coding 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 2.770452 3.401102 3.386020 0.64002009 0.30662045 -0.006392751 0.15944583 0.12156667 0.18753333 0.06596667 0.112232520 0.005340072 FALSE TRUE
ENST00000562289 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding retained_intron 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.762788 2.627053 1.611252 0.07866591 0.20928749 -0.701818628 0.09370417 0.09696667 0.08956667 -0.00740000 0.884982967 0.005340072 FALSE TRUE
ENST00000567136 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding nonsense_mediated_decay 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 2.352327 4.533052 1.440996 0.58540992 0.17530756 -1.646618389 0.13396667 0.16460000 0.07950000 -0.08510000 0.005340072 0.005340072 TRUE FALSE
ENST00000569875 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding protein_coding 17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.592870 3.722034 1.358300 0.83888456 0.22002906 -1.447577031 0.07640833 0.13350000 0.07450000 -0.05900000 0.245861624 0.005340072 FALSE TRUE
MSTRG.12813.10 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding   17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.022112 1.724235 1.749059 0.28005721 0.13992814 0.020504383 0.05475417 0.06273333 0.09696667 0.03423333 0.223040006 0.005340072 FALSE TRUE
MSTRG.12813.7 ENSG00000196155 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG4 protein_coding   17.76363 27.54212 18.11983 2.228141 0.5669987 -0.6037979 1.417117 2.556541 0.868439 0.63294286 0.04999494 -1.546811413 0.08124583 0.09470000 0.04810000 -0.04660000 0.294966955 0.005340072 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196155 E001 0.0000000       16 67277407 67277483 77 +      
ENSG00000196155 E002 0.0000000       16 67277484 67277509 26 +      
ENSG00000196155 E003 0.0000000       16 67277510 67277819 310 +      
ENSG00000196155 E004 0.0000000       16 67277820 67277945 126 +      
ENSG00000196155 E005 0.0000000       16 67277946 67278156 211 +      
ENSG00000196155 E006 0.0000000       16 67278157 67278276 120 +      
ENSG00000196155 E007 0.0000000       16 67278277 67278740 464 +      
ENSG00000196155 E008 0.6330284 0.0205004885 6.799469e-01 7.839926e-01 16 67278741 67278790 50 + 0.254 0.185 -0.577
ENSG00000196155 E009 1.3758292 0.2207604200 3.503082e-01 4.945018e-01 16 67278791 67278833 43 + 0.476 0.261 -1.276
ENSG00000196155 E010 4.5782435 0.2822039370 3.546927e-01 4.990195e-01 16 67278834 67278882 49 + 0.844 0.640 -0.833
ENSG00000196155 E011 0.5483223 0.0210248911 8.300101e-01 8.932785e-01 16 67278883 67279146 264 + 0.145 0.186 0.428
ENSG00000196155 E012 4.0159579 0.0047448833 9.632406e-02 1.848641e-01 16 67279147 67279237 91 + 0.475 0.744 1.193
ENSG00000196155 E013 4.2039919 0.0058046549 7.241588e-02 1.473605e-01 16 67279238 67279276 39 + 0.475 0.764 1.276
ENSG00000196155 E014 2.9840765 0.0073038265 3.867120e-01 5.308822e-01 16 67279277 67279531 255 + 0.660 0.532 -0.574
ENSG00000196155 E015 10.0307632 0.0206827571 3.638728e-01 5.082961e-01 16 67279532 67279552 21 + 1.083 0.982 -0.372
ENSG00000196155 E016 22.9904123 0.0311025257 5.923376e-02 1.253243e-01 16 67279553 67279588 36 + 1.471 1.281 -0.658
ENSG00000196155 E017 24.8308026 0.0308423452 5.130539e-02 1.114767e-01 16 67279589 67279595 7 + 1.505 1.312 -0.668
ENSG00000196155 E018 29.4045566 0.0195916135 4.736042e-03 1.519388e-02 16 67279596 67279626 31 + 1.605 1.357 -0.852
ENSG00000196155 E019 23.6716802 0.0065528293 3.576804e-04 1.609728e-03 16 67279627 67279661 35 + 1.526 1.252 -0.950
ENSG00000196155 E020 17.5894936 0.0156911800 4.117666e-05 2.366674e-04 16 67279662 67279742 81 + 1.465 1.067 -1.402
ENSG00000196155 E021 19.5224253 0.0349861823 6.069759e-03 1.879409e-02 16 67279743 67279774 32 + 1.471 1.156 -1.099
ENSG00000196155 E022 18.4695830 0.0313309871 2.115069e-02 5.391681e-02 16 67279775 67279789 15 + 1.421 1.163 -0.905
ENSG00000196155 E023 35.4178995 0.0013878173 4.939942e-07 4.372960e-06 16 67279790 67279875 86 + 1.701 1.408 -1.003
ENSG00000196155 E024 57.7155797 0.0064570690 1.167135e-03 4.529368e-03 16 67279876 67279895 20 + 1.856 1.671 -0.623
ENSG00000196155 E025 176.8478082 0.0045262072 9.071059e-04 3.638699e-03 16 67279896 67280183 288 + 2.303 2.179 -0.413
ENSG00000196155 E026 139.6131629 0.0007623557 1.794019e-03 6.580408e-03 16 67280184 67280396 213 + 2.179 2.088 -0.307
ENSG00000196155 E027 92.5787558 0.0003703719 1.407620e-02 3.839621e-02 16 67280397 67280543 147 + 1.998 1.915 -0.280
ENSG00000196155 E028 21.7995399 0.0147755400 2.174931e-01 3.473592e-01 16 67280544 67280710 167 + 1.388 1.289 -0.345
ENSG00000196155 E029 69.7592794 0.0003663914 1.341234e-03 5.113867e-03 16 67280711 67280806 96 + 1.905 1.778 -0.430
ENSG00000196155 E030 96.2348275 0.0003608054 1.083758e-03 4.248536e-03 16 67280882 67281005 124 + 2.031 1.920 -0.373
ENSG00000196155 E031 96.8447706 0.0004195799 7.282474e-04 3.000463e-03 16 67281091 67281184 94 + 2.034 1.919 -0.388
ENSG00000196155 E032 76.8411813 0.0003540058 2.322967e-02 5.822385e-02 16 67281567 67281644 78 + 1.918 1.834 -0.283
ENSG00000196155 E033 99.7966561 0.0034351143 9.022180e-02 1.754671e-01 16 67281724 67281837 114 + 2.020 1.955 -0.219
ENSG00000196155 E034 107.0262979 0.0007986258 2.244787e-02 5.661109e-02 16 67282009 67282107 99 + 2.055 1.981 -0.248
ENSG00000196155 E035 3.0561687 0.0109057539 7.170840e-01 8.125746e-01 16 67282181 67282200 20 + 0.529 0.596 0.305
ENSG00000196155 E036 141.6026102 0.0002328717 1.781846e-01 2.988779e-01 16 67282201 67282349 149 + 2.150 2.118 -0.107
ENSG00000196155 E037 137.9424724 0.0002644282 6.811607e-01 7.849239e-01 16 67282503 67282641 139 + 2.121 2.117 -0.012
ENSG00000196155 E038 85.8615814 0.0003667809 7.025533e-01 8.013669e-01 16 67282742 67282858 117 + 1.901 1.925 0.082
ENSG00000196155 E039 119.5833832 0.0009451954 1.114285e-01 2.076488e-01 16 67284275 67284457 183 + 2.013 2.081 0.227
ENSG00000196155 E040 223.1439256 0.0002281971 1.348259e-02 3.704154e-02 16 67284713 67285215 503 + 2.280 2.351 0.238
ENSG00000196155 E041 178.1717809 0.0023823548 5.699911e-01 6.965003e-01 16 67285290 67285536 247 + 2.233 2.227 -0.021
ENSG00000196155 E042 119.7114264 0.0003046586 8.048884e-01 8.758501e-01 16 67286274 67286363 90 + 2.044 2.062 0.059
ENSG00000196155 E043 167.4197127 0.0002168727 3.101816e-01 4.525521e-01 16 67286445 67286666 222 + 2.178 2.216 0.127
ENSG00000196155 E044 143.5826238 0.0002340549 4.634998e-03 1.491721e-02 16 67286749 67286919 171 + 2.071 2.169 0.327
ENSG00000196155 E045 192.1433064 0.0011404387 1.384238e-02 3.786856e-02 16 67287000 67287177 178 + 2.203 2.290 0.292
ENSG00000196155 E046 22.6861906 0.0008509988 8.569013e-01 9.115622e-01 16 67287572 67287897 326 + 1.359 1.354 -0.016
ENSG00000196155 E047 81.4368185 0.0015165828 2.469183e-02 6.124929e-02 16 67287898 67287899 2 + 1.815 1.927 0.375
ENSG00000196155 E048 134.8557725 0.0042618059 3.870718e-02 8.864153e-02 16 67287900 67287949 50 + 2.040 2.145 0.353
ENSG00000196155 E049 159.2564825 0.0057920274 1.226099e-01 2.236738e-01 16 67287950 67288014 65 + 2.125 2.212 0.290
ENSG00000196155 E050 250.9262111 0.0033207166 2.045508e-03 7.366690e-03 16 67288167 67288400 234 + 2.298 2.421 0.411
ENSG00000196155 E051 25.0406727 0.0016926669 5.690914e-03 1.779292e-02 16 67288476 67288488 13 + 1.238 1.459 0.769
ENSG00000196155 E052 157.3171621 0.0051781705 1.134293e-04 5.836186e-04 16 67288489 67288604 116 + 2.050 2.240 0.634
ENSG00000196155 E053 435.2076134 0.0052334238 1.616949e-03 6.014770e-03 16 67288803 67289499 697 + 2.533 2.663 0.434