ENSG00000196151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358147 ENSG00000196151 HEK293_OSMI2_2hA HEK293_TMG_2hB WDSUB1 protein_coding protein_coding 3.784941 3.057514 4.83439 0.479667 0.1908788 0.6592452 0.4603413 0.6555223 0.4431851 0.16788554 0.08058533 -0.5543864 0.11897917 0.20960000 0.09133333 -0.1182667 0.04849509 0.04849509 FALSE TRUE
ENST00000359774 ENSG00000196151 HEK293_OSMI2_2hA HEK293_TMG_2hB WDSUB1 protein_coding protein_coding 3.784941 3.057514 4.83439 0.479667 0.1908788 0.6592452 2.8023705 2.1231107 3.8580370 0.38663595 0.21106678 0.8586427 0.74714583 0.69340000 0.79723333 0.1038333 0.25568150 0.04849509 FALSE TRUE
MSTRG.19374.1 ENSG00000196151 HEK293_OSMI2_2hA HEK293_TMG_2hB WDSUB1 protein_coding   3.784941 3.057514 4.83439 0.479667 0.1908788 0.6592452 0.3257565 0.1337813 0.4587042 0.07867526 0.18337480 1.7048017 0.08969583 0.05533333 0.09623333 0.0409000 0.69013755 0.04849509 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196151 E001 0.0000000       2 159235720 159235797 78 -      
ENSG00000196151 E002 0.1482932 0.0411491872 0.3429394054   2 159235798 159235800 3 - 0.000 0.143 8.668
ENSG00000196151 E003 2.3645611 0.0066512644 0.0006191439 0.002603550 2 159235801 159235833 33 - 0.188 0.754 3.107
ENSG00000196151 E004 44.4571329 0.0007749165 0.0028871837 0.009932417 2 159235834 159236190 357 - 1.585 1.733 0.502
ENSG00000196151 E005 41.4919948 0.0005857220 0.8114693466 0.880371282 2 159248372 159248512 141 - 1.623 1.635 0.040
ENSG00000196151 E006 52.2900351 0.0004829457 0.5436755799 0.674246679 2 159256196 159256375 180 - 1.709 1.736 0.091
ENSG00000196151 E007 31.1250860 0.0008986967 0.8231557452 0.888541625 2 159257758 159257864 107 - 1.512 1.497 -0.049
ENSG00000196151 E008 19.6175894 0.0010739337 0.7109248716 0.807987235 2 159257945 159257985 41 - 1.324 1.295 -0.101
ENSG00000196151 E009 15.4804889 0.0013046614 0.3638418771 0.508264158 2 159259810 159259843 34 - 1.244 1.166 -0.277
ENSG00000196151 E010 15.1333356 0.0402381966 0.8639620358 0.916289808 2 159271702 159271795 94 - 1.217 1.182 -0.122
ENSG00000196151 E011 20.6368076 0.0088136852 0.5917901553 0.714472425 2 159275546 159275638 93 - 1.351 1.304 -0.164
ENSG00000196151 E012 39.1487177 0.0048460431 0.3123493101 0.454891414 2 159279761 159279945 185 - 1.626 1.563 -0.214
ENSG00000196151 E013 39.0889179 0.0005917129 0.6155758255 0.733826625 2 159282672 159282873 202 - 1.585 1.611 0.088
ENSG00000196151 E014 29.7490646 0.0007394440 0.1677958099 0.285328819 2 159282874 159283093 220 - 1.526 1.440 -0.296
ENSG00000196151 E015 0.2955422 0.0290508877 0.7926293121   2 159286360 159286427 68 - 0.104 0.143 0.521
ENSG00000196151 E016 0.2955422 0.0290508877 0.7926293121   2 159286428 159286582 155 - 0.104 0.143 0.521
ENSG00000196151 E017 11.3632390 0.0019087704 0.0104166675 0.029789515 2 159286583 159286746 164 - 1.187 0.925 -0.956