ENSG00000196141

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360760 ENSG00000196141 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATS2L protein_coding protein_coding 17.38349 14.99335 25.42193 0.876784 1.568679 0.761356 0.1760655 0.9032168 0.000000 0.2256668 0.0000000 -6.5128854 0.0134875 0.06093333 0.0000000 -0.06093333 2.398766e-11 2.398766e-11 FALSE TRUE
ENST00000409140 ENSG00000196141 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATS2L protein_coding protein_coding 17.38349 14.99335 25.42193 0.876784 1.568679 0.761356 1.9796703 1.0221922 3.084368 0.6313540 0.4211584 1.5839329 0.1195917 0.06476667 0.1208333 0.05606667 3.791306e-01 2.398766e-11 FALSE TRUE
ENST00000409151 ENSG00000196141 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATS2L protein_coding protein_coding 17.38349 14.99335 25.42193 0.876784 1.568679 0.761356 0.1224391 0.9795132 0.000000 0.5225735 0.0000000 -6.6286470 0.0085500 0.06840000 0.0000000 -0.06840000 1.161562e-01 2.398766e-11 FALSE TRUE
ENST00000409397 ENSG00000196141 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATS2L protein_coding protein_coding 17.38349 14.99335 25.42193 0.876784 1.568679 0.761356 9.0391169 6.4546260 13.649080 0.6931168 0.5946405 1.0792215 0.5123125 0.42806667 0.5383333 0.11026667 3.230696e-02 2.398766e-11 FALSE FALSE
ENST00000468832 ENSG00000196141 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATS2L protein_coding processed_transcript 17.38349 14.99335 25.42193 0.876784 1.568679 0.761356 4.3614965 4.4547393 5.806748 0.2969695 0.7441020 0.3816368 0.2549333 0.29883333 0.2274667 -0.07136667 2.837491e-01 2.398766e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000196141 E001 0.0000000       2 200305881 200305892 12 +      
ENSG00000196141 E002 0.5202097 0.0210784093 7.777627e-01 8.569947e-01 2 200305893 200305952 60 + 0.189 0.143 -0.488
ENSG00000196141 E003 0.5202097 0.0210784093 7.777627e-01 8.569947e-01 2 200305953 200305985 33 + 0.189 0.143 -0.488
ENSG00000196141 E004 0.2987644 0.0277515979 3.088904e-01   2 200305986 200306098 113 + 0.189 0.000 -12.699
ENSG00000196141 E005 0.5180316 0.0211515889 4.469325e-02 9.963991e-02 2 200306099 200306150 52 + 0.000 0.335 12.949
ENSG00000196141 E006 0.8125296 0.0616063380 4.400891e-01 5.817992e-01 2 200306151 200306158 8 + 0.189 0.335 1.092
ENSG00000196141 E007 0.8125296 0.0616063380 4.400891e-01 5.817992e-01 2 200306159 200306160 2 + 0.189 0.335 1.092
ENSG00000196141 E008 1.8102014 0.0082643278 7.190141e-01 8.139698e-01 2 200306161 200306275 115 + 0.464 0.407 -0.296
ENSG00000196141 E009 1.1501176 0.0187778895 4.789262e-01 6.173488e-01 2 200306276 200306282 7 + 0.374 0.250 -0.810
ENSG00000196141 E010 1.1501176 0.0187778895 4.789262e-01 6.173488e-01 2 200306283 200306292 10 + 0.374 0.250 -0.810
ENSG00000196141 E011 1.5436917 0.0088678573 1.493049e-01 2.607187e-01 2 200306293 200306375 83 + 0.503 0.250 -1.489
ENSG00000196141 E012 1.1770738 0.0104194796 7.312026e-02 1.485099e-01 2 200306376 200306418 43 + 0.464 0.142 -2.298
ENSG00000196141 E013 2.4420613 0.0089092500 1.177980e-02 3.300619e-02 2 200306419 200306523 105 + 0.683 0.250 -2.297
ENSG00000196141 E014 2.6062596 0.3360105319 6.632279e-01 7.713425e-01 2 200306524 200306552 29 + 0.604 0.475 -0.603
ENSG00000196141 E015 2.3032288 0.2647035772 7.980600e-01 8.711319e-01 2 200306553 200306553 1 + 0.539 0.474 -0.315
ENSG00000196141 E016 3.2997546 0.0533698345 6.038116e-01 7.245015e-01 2 200306554 200306567 14 + 0.658 0.573 -0.372
ENSG00000196141 E017 7.3377686 0.0477100550 6.161020e-01 7.342241e-01 2 200306568 200306601 34 + 0.951 0.880 -0.266
ENSG00000196141 E018 2.1401869 0.0099160619 4.253870e-01 5.683354e-01 2 200306688 200306692 5 + 0.538 0.408 -0.657
ENSG00000196141 E019 4.6438753 0.0033137520 8.020419e-04 3.266920e-03 2 200306693 200306717 25 + 0.908 0.407 -2.189
ENSG00000196141 E020 6.2712289 0.0025891135 4.121300e-05 2.368403e-04 2 200306718 200306726 9 + 1.034 0.469 -2.337
ENSG00000196141 E021 16.9936910 0.0372885796 4.313736e-05 2.468061e-04 2 200306727 200306871 145 + 1.424 0.884 -1.943
ENSG00000196141 E022 19.4672770 0.0009655350 3.689608e-09 4.921391e-08 2 200306872 200306922 51 + 1.476 0.980 -1.758
ENSG00000196141 E023 0.1451727 0.0427676554 6.649806e-01   2 200308887 200308949 63 + 0.105 0.000 -11.573
ENSG00000196141 E024 0.4418608 0.0256146731 1.509483e-01 2.629558e-01 2 200308950 200309090 141 + 0.260 0.000 -13.285
ENSG00000196141 E025 43.3150979 0.0005155118 9.626470e-09 1.191497e-07 2 200329431 200329480 50 + 1.761 1.450 -1.061
ENSG00000196141 E026 0.0000000       2 200351189 200351290 102 +      
ENSG00000196141 E027 2.4723615 0.0061652396 8.918101e-01 9.349171e-01 2 200372109 200372251 143 + 0.538 0.523 -0.074
ENSG00000196141 E028 0.0000000       2 200378005 200378119 115 +      
ENSG00000196141 E029 0.2214452 0.0414859021 3.534206e-01   2 200378141 200378236 96 + 0.000 0.143 11.215
ENSG00000196141 E030 0.1451727 0.0427676554 6.649806e-01   2 200378237 200378371 135 + 0.105 0.000 -11.573
ENSG00000196141 E031 3.8925522 0.0291859943 9.774556e-02 1.870578e-01 2 200383867 200384017 151 + 0.791 0.523 -1.149
ENSG00000196141 E032 58.6818070 0.0004152017 3.165681e-05 1.872982e-04 2 200389223 200389283 61 + 1.852 1.667 -0.625
ENSG00000196141 E033 0.0000000       2 200389284 200390868 1585 +      
ENSG00000196141 E034 0.0000000       2 200393077 200393273 197 +      
ENSG00000196141 E035 74.8096365 0.0019749867 1.478126e-04 7.376494e-04 2 200412311 200412419 109 + 1.948 1.784 -0.555
ENSG00000196141 E036 51.8242282 0.0080656669 2.173620e-02 5.513043e-02 2 200416379 200416428 50 + 1.783 1.640 -0.485
ENSG00000196141 E037 156.2669227 0.0029907465 1.205024e-01 2.206791e-01 2 200419250 200419496 247 + 2.219 2.172 -0.157
ENSG00000196141 E038 57.8693751 0.0056700447 3.213667e-01 4.646024e-01 2 200439122 200439328 207 + 1.791 1.740 -0.170
ENSG00000196141 E039 145.7878998 0.0002500631 9.351764e-01 9.631852e-01 2 200440649 200440784 136 + 2.165 2.172 0.024
ENSG00000196141 E040 99.2844552 0.0002882219 9.445195e-01 9.691961e-01 2 200459769 200459827 59 + 1.996 2.008 0.041
ENSG00000196141 E041 1.2103937 0.0112771512 1.723645e-02 4.546952e-02 2 200460838 200461337 500 + 0.105 0.522 3.095
ENSG00000196141 E042 0.2966881 0.0273175026 3.093164e-01   2 200463253 200463370 118 + 0.189 0.000 -12.703
ENSG00000196141 E043 124.5579269 0.0002621163 9.311019e-02 1.799852e-01 2 200467290 200467399 110 + 2.069 2.130 0.206
ENSG00000196141 E044 0.0000000       2 200469740 200469913 174 +      
ENSG00000196141 E045 114.0699393 0.0003023868 1.092353e-02 3.097810e-02 2 200469914 200470016 103 + 2.016 2.108 0.309
ENSG00000196141 E046 134.6954326 0.0002713649 4.821806e-02 1.060210e-01 2 200472832 200472992 161 + 2.100 2.168 0.229
ENSG00000196141 E047 97.1957168 0.0003394336 3.656214e-01 5.099379e-01 2 200472993 200473052 60 + 1.972 2.013 0.140
ENSG00000196141 E048 428.1363080 0.0017247449 2.469700e-10 4.069559e-09 2 200477636 200482264 4629 + 2.560 2.705 0.483